|本期目录/Table of Contents|

[1]张 杨,于泳浩.丙泊酚和瑞芬太尼联合应用对兔小肠系膜微循环的影响[J].天津医科大学学报,2015,21(03):220-222.
 ZHANG Yang,YU Yong-hao.Effect of propofol combined with remifentanil on rabbit mesenteric microcirculation[J].Journal of Tianjin Medical University,2015,21(03):220-222.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
220-222
栏目:
基础医学
出版日期:
2015-05-20

文章信息/Info

Title:
Effect of propofol combined with remifentanil on rabbit mesenteric microcirculation
文章编号:
1006-8147(2015)03-0220-03
作者:
张 杨1于泳浩2
(1.天津医科大学第四中心临床学院麻醉科,天津 300140;2.天津医科大学总医院麻醉科,天津 300052)
Author(s):
ZHANG Yang1 YU Yong-hao2
(1. Department of Anesthesiology, The Fourth Central Clinical College, Tianjin Medical University,Tianjin 300140,China; 2. Department of Anesthesiology, General Hospital ,Tianjin Medical University, Tianjin 300052,China)
关键词:
丙泊酚瑞芬太尼微循环
Keywords:
propofol remifentanil rabbit microcirculation
分类号:
R614
DOI:
-
文献标志码:
A
摘要:

目的:探讨丙泊酚和瑞芬太尼联合应用对兔小肠系膜微循环的影响。方法: 将30只新西兰大白兔随机分为对照组(C组),丙泊酚组(P组),丙泊酚联合瑞芬太尼组(P+R组),每组10只。建立兔全麻模型后,C组持续泵入生理盐水,P组静脉持续泵入丙泊酚,P+R组静脉持续泵入瑞芬太尼和丙泊酚,分别记录3组给药前及给药0.5 h后新西兰大白兔的心率(HR)、平均动脉压(MAP),采用旁流暗视野技术测定新西兰大白兔小肠系膜微循环总血管密度(TVD)、灌注血管密度(PVD)、灌注血管比例(PPV)、微血管流动指数(MFI)。结果:与C组相比,给药后P组HR减慢, MAP 轻度下降,微循环血流明显增加,TVD、PVD、PPV、MFI均有所增加,差异均有统计学意义(P<0.05)。与C组相比,给药后P+R组HR减慢,MAP显著下降,微循环血流明显减少,且差异均有统计学意义(P<0.05)。结论:丙泊酚对兔小肠系膜循环有改善作用,丙泊酚和瑞芬太尼联合应用对兔小肠系膜微循环有抑制作用。

Abstract:
Objective: To investigate the effects of combination of propofol and remifentanil on mesenteric microcirculation in rabbits. Methods: Thirty New Zealand white rabbits were randomly divided into control group (group C), propofol group (P group) and propofol-remifentanil combination group (P+R group) with 10 rabbits in each group. Animal model was established given general anestyesia and 0.9% normal saline solution was infused in C group while propofol was infused in P group . Propofol combined with remifentanil administrated in P+R group. Multiple parameters of the rabbits in 3 groups were recorded before and half an hour after the administration of drugs, including heart rate (HR), mean arterial pressure (MAP),total vessel density (TVD) of mesenteric microcirculation by sidestream dark-field (SDF) technique, perfused vessel density (PVD), proportion of perfused vessels (PPV) and microvascular flow index (MFI). Results: Compared with group C, after administration of propofol (P group), HR in the group dropped, MAP decreased slightly, and blood flow of microcirculation increased significantly (p <0.05). In P+R group, HR and MAP decreased significantly with reduced blood flow in microcirculation, and the differences were statistically significant (P <0.05). No significant change of microcirculation parameters was found before and after normal saline solution administration in Group C. The microcirculation was enhanced after propofol infusion in the Pgroup (P <0.05). After the after administration of propofol and remifentanil, microcirculation for P + R group was significantly inhibited (P<0.05). Conclusion: Propofol improves mesenteric circulation while a combination of propofol and remifentanil inhibits mesenteric microcirculation in rabbit model.

参考文献/References:

[1]Pittman R N. Oxygen transport in the microcirculation and its regulation[J]. Microcirculation, 2013, 20(2): 117[2]Bezemer R, Bartels S A, Bakker J, et al. Clinical review: Clinical imaging of the sublingual microcirculation in the critically ill - where do we stand[J]. Crit Care, 2012, 16(3): 224
[3]Hernandez G, Bruhn A, Castro R, et al. The holistic view on perfusion monitoring in septic shock[J]. Curr Opin Crit Care, 2012, 18(3): 280
[4]颜默磊,严静.多巴胺和去甲肾上腺素对脓毒性休克患者微循环的影响[J].中国临床药理学与治疗学,2013,18(5):565
[5]Koch M, De Backer D, Vincent J L, et al. Effects of propofol on human microcirculation[J]. Br J Anaesth, 2008, 101(4): 473[6]Jung C, Rodiger C, Lauten A, et al. Long-term therapy with propofol has no impact on microcirculation in medicalintensive care patients[J]. Med Klin (Munich), 2009, 104(5): 334
[7]Chen H I, Hsieh N K, Kao S J, et al. Protective effects of propofol on acute lung injury induced by oleic acid in conscious rats[J]. Crit Care Med, 2008, 36(4): 1214
[8]Kemmochi M, Ichinohe T, Kaneko Y. Remifentanil decreases mandibular bone marrow blood flow during propofol or sevoflurane anesthesia in rabbits[J]. J Oral Maxillofac Surg, 2009, 67(6): 1245
[9]Degoute C S, Ray M J, Manchon M, et al. Remifentanil and controlled hypotension; comparison with nitroprusside or esmolol during tympanoplasty[J]. Can J Anaesth, 2001, 48(1): 20

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备注/Memo

备注/Memo:

作者简介 张杨(1982-),男,主治医师,硕士在读,研究方向:临床麻醉;通信作者:于泳浩,E-mailyuyonghao@126.com.

 

更新日期/Last Update: 2015-05-27