|本期目录/Table of Contents|

[1]金海涵,林宝禄,刘树业.天津地区丙型肝炎病毒基因型与临床的相关性研究[J].天津医科大学学报,2014,20(04):286-288.
 JIN Hai-han,LIN Bao-lu,LIU Shu-ye.Correlation between hepatitis C virus genotypes and clinical index in Tianjin[J].Journal of Tianjin Medical University,2014,20(04):286-288.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20
期数:
2014年04期
页码:
286-288
栏目:
临床医学
出版日期:
2014-07-08

文章信息/Info

Title:
Correlation between hepatitis C virus genotypes and clinical index in Tianjin
文章编号:
1006-8147(2014)04-0286-03
作者:
金海涵1 林宝禄2 刘树业3
(1.天津医科大学三中心临床学院检验科,天津 300170;2.天津市滨海新区塘沽中心血站,天津 300456;3.天津市第三中心医院检验科;天津市人工细胞重点实验室,天津 300170)
Author(s):
JIN Hai-han1LIN Bao-lu2 LIU Shu-ye3
(1. Department of Laboratory ,The Third Central Clinical College , Tianjin Medical University , Tianjin 300170, China; 2.Tianjin Binhai Tanggu Blood Station , Tianjin 300456 ,China; 3.The Third Central Clinical Hospital of Tianjin; Tianjin Key laboratory of artificial cell ,Tianjin 300170 , China)
关键词:
丙型肝炎病毒基因分型基因测序天津地区
Keywords:

Hepatitis C virus genotype gene sequencingTianjin region

分类号:
R575.1
DOI:
-
文献标志码:
A
摘要:
目的: 研究丙型肝炎病毒基因型,了解天津地区丙型肝炎的分布情况。方法: 收集252例丙型肝炎患者的血清标本,采用基因测序法进行HCV基因型的检测,并对基因型与其他临床指标进行分析。结果: 252例丙型肝炎患者分别感染1b、1a、1c、2a、2i、3a、3b、4a和6a共9种基因亚型,其中1b型占59.9%,其次是3a型,占12.7%。对1型、2型、3型和4型4种基因型进行肝功能、HCV RNA病毒载量比较,经单因素方差分析有明显统计学差异(P<0.05);对HCV感染的不同肝病程度患者的基因型分布进行分析,无显著性差异(P>0.05)。结论: 天津地区丙型肝炎病毒感染以1b型为主,其次为3a型。HCV基因型与HCV RNA 病毒载量、肝脏损伤指标有明显统计学差异。
Abstract:

Objective To study the HCV genotype in chronic hepatitis C patients and explore the distribution of hepatitis C in Tianjin region. Methods Serum specimens from 252 patients hepatitis C were collected for genotype by gene sequencing technique. ResultsIn the 252 specimens with HCV infection, nine gene genotypes were detected, including 1b(59.9%),1a,1c,2a,2i,3a(12.7%),3b,4a and 6a. Significant difference was observed between HCV genotypes and HCV RNA,liver function (P<0.05). No significant difference between HCV genotypes and various liver diseases distribution was found (P>0.05). Conclusion:HCV 1b is the most prevalent type in Tianjin, followed by type 3a. HCV genotypes are associated with HCV RNA level and liver function.

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相似文献/References:

备注/Memo

备注/Memo:

作者简介 金海涵(1979-),女,硕士在读,研究方向:临床检验诊断学 ;

通信作者:刘树业 ,E-mail:lshye@163.com

更新日期/Last Update: 2014-06-06