|本期目录/Table of Contents|

[1]张 俊,孟令贺,单士军,等. 康复新液对实验性大鼠皮肤切割伤痂下愈合的影响[J].天津医科大学学报,2014,20(03):192-195.
 ZHANG Jun,MENG Ling-he,SHAN Shi-jun,et al.Effect of Kangfuxin liquid on subcrustal wound healing of rat[J].Journal of Tianjin Medical University,2014,20(03):192-195.
点击复制

 康复新液对实验性大鼠皮肤切割伤痂下愈合的影响(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年03期
页码:
192-195
栏目:
基础医学
出版日期:
2014-05-20

文章信息/Info

Title:
Effect of Kangfuxin liquid on subcrustal wound healing of rat
文章编号:
1006-8147(2014)03-0192-04
作者:
 张 俊1孟令贺1单士军2张理涛2

(1. 天津医科大学研究生院,天津 300070;2. 天津市中医药研究院附属医院皮肤科,天津 300120)

Author(s):
ZHANG Jun1 MENG Ling-he1 SHAN Shi-jun2 ZHANG Li-tao2
(1. Graduate School, Tianjin Medical University, Tianjin 300070, China; 2. Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China)
关键词:
康复新液皮肤切割伤组织病理学大鼠
Keywords:
Kangfuxin liquid cutaneous excision wound histopathology rats
分类号:
-
DOI:
-
文献标志码:
A
摘要:
目的:观察康复新液对实验性大鼠皮肤切割伤痂下愈合的影响。方法:建立大鼠皮肤切割伤伤口痂下愈合模型,以不同浓度的康复新液(高剂量组、低剂量组)作用于伤口,观测创面愈合情况,计算愈合百分率,并分别于术后第4、7、14天取创面组织,HE常规染色观察创面新生肉芽组织及形态学改变。结果:各时间点康复新液高、低剂量组创面平均愈合率均显著高于阴性对照组,差异有统计学意义(P<0.01)。HE染色显示,与阴性对照组相比,术后第4、7天,康复新液各组肉芽组织丰富而炎性细胞浸润较少,术后第14天,康复新液组胶原纤维数量更多,排列更整齐,表皮结构更加完整。 结论:康复新液对促进大鼠皮肤切割伤的痂下愈合作用显著。
Abstract:
Objective: To investigate the effect of Kangfuxin liquid on the rat skin during the process of subcrustal healing. Methods: Excision wounds of skin were produced in experimental rats which were divided into Kangfuxin liquid high-dose group and low-dose group. Observation of wound healing, calculation of the healing rate, and histological examination were undertaken at different time points. Results: The average healing rate of both high-dose and low-dose group were significantly higher than those of negative group (P<0.01). HE staining showed that compared with negative group, less inflammatory cells infiltration butmore new granulation tissue were found in Kangfuxin liquid groups than those in negative group after 4 and 7 days of wounding, and epidermis hyperplasia. Conclusion: Kangfuxin liquid can significantly promote subeschar wound healing ability of rats.

参考文献/References:

[1] 焦春香, 刘光明, 周萍. 天然药物康复新的研究进展[J]. 时珍国医国药, 2008,19(11):2623
[2] 邹金凯, 傅得兴. 康复新液的临床应用[J]. 首都医药, 2008,8(4):29
[3] 陈筱云. 康复新液治疗褥疮60例的临床观察[J]. 中国实用医药, 2013,8(7):158
[4] 高黎黎, 王鲁平, 李光辉. 康复新的临床新用途[J]. 中国误诊学杂志, 2006,6(7):1390
[5] 刘碧霞, 李玉云, 陶佳. 康复新液不同用药时间在儿童耳前瘘管换药中的疗效观察[J]. 浙江中医药大学学报, 2013,37(1):94
[6] 宋芹, 张臻, 毛茜, 等. 美洲大蠊提取物对小鼠真皮成纤维细胞迁移影响的初步研究[J]. 中药与临床, 2013,4(1):34
[7] 李珊瑚, 李勇敏, 彭淑珍. 康复新液对家兔创伤愈合的影响[J]. 临床和实验医学杂志, 2006,5 (6):730
[8] 舒崇湘, 程天民. 康复新对单纯皮肤创面和合并全身放射损伤时的促愈作用[J]. 第三军医大学学报, 1999,21(3):16
[9] 苏金仁, 陈瑾, 黄秀深, 等. 康复新液对大鼠胃溃疡病理瘢痕形成的影响[J]. 中药材, 2013,36(6):979
[10] 叶本兰, 舒崇湘, 程天民, 等. 电离辐射对3T3细胞膜钙依赖性钾通道的影响及康复新的作用[J]. 中国应用生理学杂志, 2002,18(3):83
[11] 王光强, 陈鉴东, 徐小军, 等. 固相萃取高效液相色谱法测定康复新液中有效成分KFX-4[J]. 亚太传统医药, 2012,8(12):24

相似文献/References:

备注/Memo

备注/Memo:
 作者简介 张俊(1987-),女,硕士在读,研究方向:皮肤病与性病学;通信作者:张理涛,E-mail:zhanglitao@medmailcom.cn。
更新日期/Last Update: 2014-05-12