|本期目录/Table of Contents|

[1]梁绍平,王华庆.盐酸埃克替尼治疗晚期非小细胞肺癌的临床疗效观察[J].天津医科大学学报,2015,21(03):51-54.
 LIANG Shao-ping,WANG Hua-qing.Clinical observation of icotinib hydrochloride in the treatment of advanced non-small cell lung cancer[J].Journal of Tianjin Medical University,2015,21(03):51-54.
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盐酸埃克替尼治疗晚期非小细胞肺癌的临床疗效观察(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
51-54
栏目:
临床医学
出版日期:
2015-05-20

文章信息/Info

Title:
Clinical observation of icotinib hydrochloride in the treatment of advanced non-small cell lung cancer
文章编号:
1006-8147(2015)0-0051-04
作者:
梁绍平王华庆
(天津医科大学肿瘤医院淋巴瘤科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津300060)
Author(s):
LIANG Shao-ping  WANG Hua-qing
(Department of Lymphoma, Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China)
关键词:
盐酸埃克替尼非小细胞肺癌表皮生长因子受体分子靶向治疗
Keywords:
icotinib hydrochloride advanced non-small cell lung cancer epidermal growth factor receptor molecular target therapy
分类号:
R734.2
DOI:
-
文献标志码:
A
摘要:

目的:观察盐酸埃克替尼治疗晚期非小细胞肺癌的临床疗效及安全性。方法:回顾分析埃克替尼治疗30例晚期非小细胞肺癌的临床效果,采用口服治疗,125 mg/次,3次/d,评价其近期疗效、无病进展生存期及不良反应。结果:30例患者在接受埃克替尼1个月治疗后,完全缓解(CR)0例,部分缓解(PR)10例,疾病稳定(SD)14例,疾病进展(PD)6例,客观有效率(ORR)为33.3%,疾病控制率(DCR)为80%。在各临床因素中,ECOG评分及是否伴有脑转移与近期疗效具有相关性(P<0.05)。截至随访结束,24例(80%)出现PFS终点事件,全组中位PFS为8.0个月。患者的PFS主要与患者年龄、吸烟与否、ECOG评分以及是否伴有其他部位的转移有关(P<0.05)。全组不良反应发生率为43.3%,主要为皮疹5例(16.7%),皮肤瘙痒2例(6.7%),腹泻 1例(3.3% ),胃部不适1例( 3.3%),肝功能轻度损害6例(20.0% )。结论:盐酸埃克替尼治疗晚期非小细胞肺癌疗效肯定,耐受性好。

 

Abstract:
Objective To observe the clinical effect and toxicity of icotinib in 30 patients with advanced NSCLC. Methods: Thirty patients with advanced NSCLC were retrospectively analyzed. Icotinib (125 mg,three times a day) was orally taken by patients, to evaluate the short-term response, progression free survival and toxicity. Results Among the 30 patients, no cases experienced complete response(CR), 10 cases experienced partial response(PR), 14 cases were with stable diseases(SD), 6 cases were with progression disease(PD), and the tumor objective response rate (ORR) and disease control rate(DCR) were 33.3%(10/30) and 80.0%(24/30), respectively. ECOG and brain metastasis were associated with short-term response. At the end of the follow-up period, twenty-four cases had progression disease. The median PFS was 8.0 months, significantly correlated with age, smoking history, ECOG, and metastasis (P<0.05). The incidence of side effects was 43.3%, including rash (16.7%) ,itch of skin(6.7%) ,diarrhea(3.3%) , heartburn(3.3%), and mild impair of liver function(20.0%). Conclusion: Icotinib hydrochloride is effective with high drug tolerance for advanced non-small cell lung cancer.

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备注/Memo

备注/Memo:
作者简介 梁绍平(1988-),女,硕士在读,研究方向:肿瘤学; 通信作者:王华庆,E-mail:huaqingw@163 .com。
更新日期/Last Update: 2015-01-22