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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

29卷

期数:

2023年06期

页码:

617-621

栏目:

基础医学

出版日期:

2023-11-20

文章信息/Info

Title:

Effect of intrathoracic pressure fluctuation on blood pressure in animal model of OSAHS

文章编号:

1006-8147(2023) 06-0617-05

作者:

李伯君¹; 裴祥¹; 陈政杰²; 梁柯欣²; 刘珊³; 赵晓赟¹; 2

（1.天津大学胸科医院呼吸与危重症医学科，天津300222；2.天津医科大学胸科临床学院， 天津300270；3.天津市心血管病研究所， 天津 300222）

Author(s):

LI Bo-jun¹; PEI Xiang¹; CHEN Zheng-jie²; LIANG Ke-xin²; LIU Shan³; ZHAO Xiao-yun¹; 2

（1.Department of Respiratory and Critical Care Medicine， Chest Hospital of Tianjin University， Tianjin 300222， China; 2. Clinical College of Thoracic Medicine， Tianjin Medical University， Tianjin 300270， China; 3. Tianjin Institute of Cardiovascular Diseases， Tianjin 300222， China）

关键词:

阻塞性睡眠呼吸暂停低通气综合征; 间歇性气道阻塞; 胸腔压力; 高血压

Keywords:

obstructive sleep apnea-hypopnea syndrome;  intermittent airway obstruction;  intrathoracic pressure;  hypertension

分类号:

R563.9，Q95-33

DOI:

-

文献标志码:

A

摘要:

目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）不发生低氧血症的情况下，胸腔压力波动对高血压的影响。方法：选取18只健康新西兰长耳兔，应用随机数字表法将其分为对照组（A组）、OSAHS模型组（B组）、OSAHS不伴低氧组（C组），每组6只。A组保持气道持续开放，B组和C组均通过设置不同的气道狭窄程度建立OSAHS模型，建模成功出现间歇性低氧血症及胸腔压力变化时，C组通过提高吸氧浓度而不发生低氧血症。观察其血压、心率变化。结果：实验过程中，A组与C组均未发生低氧血症，两组经皮血氧饱和度（SpO2）比较差异无统计学意义，B组SpO2明显下降，与其他两组差异有统计学意义（F=32.48，P<0.05）。经过4 h实验后，B组胸腔负压低于其他两组，C组胸腔负压低于A组（F=116.68，P<0.05）；B组心率快于其他两组，C组心率快于A组（F=66.91，P<0.05）；B组舒张压和收缩压均高于其他两组，C组舒张压和收缩压高于A组（F=30.18、33.06，均P<0.05）；在实验进行的前3 h，3组各个时间点的心率、收缩压、舒张压亦有差异（F=45.33、65.26、14.03、30.39、20.98、14.43、17.42、25.02，均P<0.05）。结论：OSAHS导致间歇性胸腔压力波动这一呼吸力学因素是OSAHS相关性高血压的重要影响因素。

Abstract:

Objective： To investigate the effect of fluctuating intrathoracic pressure on hypertension in the absence of obstructive sleep apnea-hypopnea syndrome（OSAHS） hypoxemia. Methods：A total of 18 healthy New Zealand long ear rabbits were selected and divided into control group（group A）， OSAHS model group（group B） and OSAHS without hypoxia group（group C） by random number table method， with 6 rabbits in each group. Group A kept the airway open continuously，OSAHS models were established by setting different degrees of airway stenosis in both group B and group C. When intermittent hypoxemia and chest pressure changes were successfully established in the modeling， animals in group C were prevented from hypoxemia by increasing oxygen absorption concentration. The changes of blood pressure and heart rate were observed. Results：During the experiment， no hypoxemia occurred in the experimental animals of group A and group C， and there was no statistically significant difference in pulse oxygen saturation（SpO2） between the two groups， while SpO2 of experimental animals in group B decreased significantly， with statistical significance compared with the other two groups （F=32.48，P<0.05）. After 4 hours of experiment， the thoracic negative pressure of animals in group B was lower than that in the other two groups， and that in group C was lower than that in group A（F=116.68，P<0.05）. The heart rate of animals in group B was faster than that in the other two groups， and that in group C was faster than that in group A（F=66.91，P<0.05）. Diastolic and systolic blood pressure in group B were higher than those in the other two groups， and diastolic and systolic blood pressure in group C were higher than those in group A （F=30.18， 33.06， both P<0.05）. During the first 3 hours of the experiment， the heart rate， systolic blood pressure and diastolic blood pressure of the 3 groups were also different at each time point （F=45.33， 62.65 ，65.26，14.03， 30.39，20.98，14.43，17.42 ，25.02，all P<0.05）. Conclusion：Intermittent fluctuation of intrathoracic pressure caused by OSAHS is an important respiratory mechanical factor affecting OSAHS-related hypertension.

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相似文献/References:

[1]李佳丽,姚朱华,马 梅,等.冠心病合并阻塞性睡眠呼吸暂停低通气综合征临床分析[J].天津医科大学学报,2014,20(06):472.
[2]姜珊,王彦,张静,等.OSAHS合并肥胖低通气综合征患者的临床特征分析[J].天津医科大学学报,2021,27(01):17.
　JIANG Shan,WANG Yan,ZHANG Jing,et al.Study on the clinical characteristics of obstructive sleep apnea-hypopnea syndrome combined with obesity hypopnea syndrome[J].Journal of Tianjin Medical University,2021,27(06):17.

备注/Memo

备注/Memo:

基金项目 天津市卫生健康科技项目（KJ20015）；天津市津南区科技计划项目（20200116）
作者简介 李伯君（1982），男，硕士，主治医师，研究方向：呼吸危重症、睡眠呼吸疾病；通信作者：赵晓赟，E-mailzxydoctor@163.com。

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更新日期/Last Update: 2023-12-01