|本期目录/Table of Contents|

[1]杜林,陈峰,徐医军 综述,等.非编码RNA对肺癌中铁死亡调控作用的研究进展[J].天津医科大学学报,2022,28(05):568-571.
点击复制

非编码RNA对肺癌中铁死亡调控作用的研究进展(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
28卷
期数:
2022年05期
页码:
568-571
栏目:
综述
出版日期:
2022-09-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2022)05-0568-04
作者:
杜林; 陈峰; 徐医军 综述; 张逊 审校
（天津市胸科医院胸外科，天津300222）
Author(s):
-
关键词:
肺癌; 铁死亡; 非编码RNA; 分子机制
Keywords:
-
分类号:
R34
DOI:
-
文献标志码:
A
摘要:
铁死亡是最近发现的一种新型细胞程序性死亡方式，在形态学与发生机制等方面区别于其他的细胞死亡方式。同时，非编码RNA（ncRNA）可以通过影响mRNA转录等作用调节下游靶蛋白的表达。近年来研究发现，ncRNA可以通过影响铁离子代谢、细胞脂代谢和调控谷胱甘肽过氧化物酶4（GPX4）等多种机制，参与肺癌的细胞铁死亡过程。因此，与细胞铁死亡相关的ncRNA和下游的靶基因可能成为新的肺癌临床标志物和治疗靶点。
Abstract:
-

参考文献/References:

[1] INGOLD I，BERNDT C，SCHMITT S，et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis [J]. Cell，2018，172（3）：409-422.
[2] WAN S Y，ROHITHA S，MATTHEW E W，et al. Regulation of ferroptotic cancer cell death by GPX4[J]. Cell，2014，156（1）：317-331.
[3] LEE R C，FEINBAUM R L，AMBROS V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [J]. Cell，2019，75（5）：843-854.
[4] LV W Y，LI C H，LIN H R，et al. A high-integrated DNA biocomputing platform for MicroRNA sensing in living cells [J]. Biosens Bioelectron，2022，207（17）：114183-114190.
[5] POTOCHI L，KARBARZ M，ADAMCZYK-GROCHALA J，et al. Silver birch pollen-derived microRNAs promote NF-κB-mediated inflammation in human lung cells[J]. Sci Total Environ，2021，800（15）：149531-149539.
[6] WANG Z H，WANG D，GUO S，et al. Long noncoding RNA distal-less homeobox 2 antisense 1 restrains inflammatory response and apoptosis of periodontal ligament cells by binding with microRNA-330-3p to regulate Ro60，Y RNA binding protein[J]. Arch Oral Biol，2022，133（6）： 105298-105303.
[7] LIU N，LIN X，HUANG C. Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance [J]. Brit J Cancer，2019，122（2）：1-14.
[8] SATO H，TAMBA M，ISHII T，et al. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins[J]. J Biol Chem，1999，274（7）：11455-11458.
[9] CHAO L，GUO L，YANG N，et al. miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma [J]. Cancer Cell Int，2017，17（1）：1-7.
[10] HOU Y，CAI S，YU S，et al. Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer[J]. Acta Bioch Bioph Sin，2021，56（3）：3-11.
[11] DENG S H，WU D M，LI L，et al. miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549[J]. Biochem Bioph Res Co，2021，549（10）：54-60.
[12] LI S，JIA H，ZHANG Z，et al. LncRNA GAS6-AS1 facilitates the progression of breast cancer by targeting the miR-324-3p/SETD1A axis to activate the PI3K/AKT pathway[J]. Eur J Cell Biol，2020，99（8）：151124-151131.
[13] HUANG X H，WANG Q，CHEN J S，et al. Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma： miR-338 is downregulated [J]. Hepatol Res，2010，39（8）：786-794.
[14] PENG Y，LIU Y M，LI L C，et al. MicroRNA-338 inhibits growth，invasion and metastasis of gastric cancer by targeting NRP1 expression [J]. PLoS One，2014，9（4）：e94422-e94430.
[15] 张伟，彭燕琪，费思佳，等. miR-338通过靶向GPX4抑制非小细胞肺癌细胞增殖[J]. 现代肿瘤医学，2020，28（23）： 4041-4045.
[16] CHEN J S，LIANG L L，XU H X，et al. MiR-338-3p inhibits epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma cells [J]. Oncotarget，2017，8（42）：112-118.
[17] TARANGELO A，MAGTANONG L，BIEGING-ROLETT K T，et al. p53 suppresses metabolic stress-induced ferroptosis in cancer cells [J]. Cell Rep，2018，22（3）：569-579.
[18] XIE Y，ZHU S，SONG X，et al. The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity [J]. Cell Rep，2017，20（7）：1692-1699.
[19] MAO C，WANG X，LIU Y，et al. A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53 [J]. Cancer Res，2018，56（112）：3484-3490.
[20] SONG Z，JIA G，MA P，et al. Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis[J]. Life Sci，2021，276（7689）：119399-119406.
[21] KENNETH N，MUDIE S，NARON S，et al. TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signaling [J]. Biochem J，2013，13（28）：449-457.
[22] LU J，XU F，LU H. LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53[J]. Life Sci，2020，260（11）：118305-118312.
[23] YANG Y R，ZANG S Z，ZHONG C L，et al. Increased expression of the lncRNA PVT1 promotes tumorigenesis in non-small cell lung cancer [J]. Int J Clin Exp Patho，2014，7（10）：6929-6935.
[24] LI Y，ZHANG J，PAN S，et al. CircRNA CDR1 as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis[J]. Thorac Cancer，2020，11（3）：112-120.
[25] BAI T，LIANG R，ZHU R，et al. MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells[J]. J Cell Physiol，2020（11）：342-352.
[26] LE J，NING K，LI T，et al. Ferroptosis as a p53-mediated activity during tumour suppression [J]. Nature，2019，（18）：262-270.
[27] YANG X，ZHANG Y，FAN H. Downregulation of SBF2-AS1 functions as a tumor suppressor in clear cell renal cell carcinoma by inhibiting miR-338-3p-targeted ETS1[J]. Cancer Gene Ther，2020，（45）：23-33.
[28] KIRILL B，JOSEPH MH，LI Z，et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis[J]. Nature，2019，575（21）：688-692.
[29] WU M，ZHANG X，ZHANG W，et al. Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis [J]. Nat Commun，2022，13（16）：1371-1381.
[30] SONG X，LIU J，KUANG F，et al. PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis [J]. Cell Rep，2021，34（8）： 108767-108775.
[31] HONG T，LEI G，CHEN X，et al. PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer [J]. Chem Biol Interact，2022，352（2）：101928-101936.
[32] LI H，LIU L. Zinc moderates circular RNA CircFOXP1 expression in order to regulate ferroptosis during lung adenocarcinoma[J]. Redox Biol，2021，42（11）：109760-109768.
[33] KUGANESAN N，DIAMINI S，TILLEKERATNE L M，et al. Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21，CDKs，RB，and E2F[J]. J Biol Chem，2021，297（6）：101365-101374.

相似文献/References:

[1]仝颖娜,刘晓彬,张露方,等.血胱抑素C等对肺癌患者化疗过程中肾损伤的评价[J].天津医科大学学报,2017,23(02):143.
　TONG Ying-na,LIU Xiao-bin,ZHANG Lu-fang,et al.Evaluation of serum cystatin C in kidney function damage for patients with lung cancer during chemotherapy[J].Journal of Tianjin Medical University,2017,23(05):143.
[2]陈鸿运,李晓明,黄国胜,等.LncRNA PTCSC3过表达诱导非小细胞肺癌A549凋亡和氧化损伤并抑制细胞增殖和迁移[J].天津医科大学学报,2021,27(05):467.
　CHEN Hong-yun,LI Xiao-ming,HUANG Guo-sheng,et al.Overexpression of LncRNA PTCSC3 induces apoptosis and oxidative damage of non-small cell lung cancer A549 and inhibits their proliferation and migration[J].Journal of Tianjin Medical University,2021,27(05):467.
[3]何磊,杜佳辉,李娜.miR-152通过靶向FGF2抑制肺癌A549细胞系的增殖侵袭[J].天津医科大学学报,2022,28(02):145.
　HE Lei,DU Jia-hui,LI Na.The effect of miR-152 on the proliferation and invasion of lung cancer A549 cell line regulated by FGF2[J].Journal of Tianjin Medical University,2022,28(05):145.
[4]李洋 综述,郭锋杰,孟旭英,等.树突状细胞外泌体与肺癌免疫治疗[J].天津医科大学学报,2023,29(01):94.
[5]张思培,陈丽娟,秦建文,等.肺腺癌合并活动性肺结核患者用药讨论1例[J].天津医科大学学报,2023,29(04):440.
[6]杨秋慧,郝名英,刘思琪,等.Erastin和BIBR1532联合应用对胃癌细胞增殖的影响[J].天津医科大学学报,2023,29(06):575.
　YANG Qiu-hui,HAO Ming-ying,LIU Si-qi,et al.Effects of the combination of Erastin and BIBR1532 on the proliferation of gastric cancer cells[J].Journal of Tianjin Medical University,2023,29(05):575.
[7]刘思琪,郝名英,黄欣宇,等.端粒酶TERT通过向线粒体转位抵抗胃癌细胞铁死亡的发生机制[J].天津医科大学学报,2024,30(02):110.[doi:10.20135/j.issn.1006-8147.2024.02.0110]
　LIU Siqi,HAO Mingying,HUANG Xinyu,et al.The mechanism of telomerase TERT resisting ferroptosis in gastric cancer cells by translocating to mitochondria[J].Journal of Tianjin Medical University,2024,30(05):110.[doi:10.20135/j.issn.1006-8147.2024.02.0110]
[8]郝名英,刘思琪,黄欣宇,等.Erastin对骨肉瘤细胞生长及增殖的影响[J].天津医科大学学报,2024,30(03):193.[doi:10.20135/j.issn.1006-8147.2024.03.0193]
　HAO Mingying,LIU Siqi,HUANG Xinyu,et al.Effects of erastin on the growth and proliferation of osteosarcoma cells[J].Journal of Tianjin Medical University,2024,30(05):193.[doi:10.20135/j.issn.1006-8147.2024.03.0193]
[9]曾晓娇,田玲,张景云.基于铁死亡通路的高糖诱导人肾小管上皮细胞损伤的机制研究[J].天津医科大学学报,2024,30(03):239.[doi:10.20135/j.issn.1006-8147.2024.03.0239]
　ZENG Xiaojiao,TIAN Ling,ZHANG Jingyun.Exploring the mechanism of high glucose-induced injury in human renal tubular epithelial cells based on the ferroptosis pathway[J].Journal of Tianjin Medical University,2024,30(05):239.[doi:10.20135/j.issn.1006-8147.2024.03.0239]
[10]缪道玉,于方海 综述,张西波 审校.调节性细胞死亡方式参与阻塞性黄疸引起肝细胞损伤的机制研究[J].天津医科大学学报,2024,30(04):377.[doi:10.20135/j.issn.1006-8147.2024.04.0377]

备注/Memo

备注/Memo:
作者简介 杜林（1988-），男，主治医师，博士在读，研究方向：肺癌基础研究；通信作者：张逊，E-mail： Zhangxun69@163.com。
更新日期/Last Update: 2022-09-20