«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

27卷

期数:

2021年01期

页码:

61-64

栏目:

临床医学

出版日期:

2021-01-20

文章信息/Info

Title:

Study of correlation between uric acid level and infectious mononucleosis

文章编号:

1006-8147（2021）01-0061-04

作者:

张丽; 逄崇杰; 巩路

天津医科大学总医院感染科，天津300052

Author(s):

ZHANG Li; PANG Chong-jie; GONG Lu

Department of Infectious，General Hospital，Tianjin Medical University，Tianjin 300052，China

关键词:

传染性单核细胞增多症; 尿酸; 受试者工作特征曲线; 风险比

Keywords:

infectious mononucleosis; uric acid; receiver operating characteristic curve; odds ratio

分类号:

R512.7

DOI:

-

文献标志码:

A

摘要:

目的：探讨尿酸水平与传染性单核细胞增多症（IM）之间的关系。方法：本研究入组95例IM患者（男性47例、女性48例）和95名健康对照者，临床资料按性别分类。采用受试者工作特征（ROC）曲线分析法确定预测发生IM的尿酸切点值，用二元Logistic回归计算风险比（OR）。结果：IM患者的尿酸水平明显低于对照组，男性尿酸水平明显高于女性。ROC曲线显示尿酸对IM具有预测价值，男性和女性的尿酸切点值分别为326.00 μmol/L和243.50 μmol/L，诊断准确率分别为76.596%和80.208%。二元Logistic回归分析显示，男女尿酸较低的四分位数中存在显著的IM风险，且低尿酸水平的女性更易患此病。其中，尿酸第一四分位的男性和女性的原始OR值分别为24.000和52.500，加入协变量后的OR值分别为31.437和301.746（均P<0.01）。结论： 尿酸和IM呈负相关，IM患者的抗氧化储备逐渐减少，尤以女性为著。

Abstract:

Objective: To investigate the association between uric acid（UA）level and infectious mononucleosis（IM）. Methods: A total of 95 patients （47 men and 48 women） with IM were recruited，along with 95 healthy controls. Clinical data were classified by patients′ sex. Receiver operating characteristic（ROC） curve analysis was adopted to determine the cut off values of UA for IM diagnosis and prediction of IM. Crude and adjusted odds ratios（OR） of UA for IM were analyzed by binary Logistic regression. Results: The UA levels were significantly lower in IM patients compared with those in controls. In addition，UA levels in men were significantly higher than those in women. The ROC curve demonstrated diagnostic and predictive values of UA for IM in both sexes. The UA cut off values were 326.00 and 243.50 μmol/L for diagnosing IM in men and women，respectively，with a diagnostic accuracy of 76.596% and 80.208%，respectively. Binary Logistic regression analysis revealed a significant risk of IM in the low UA quartiles in both sexes. Following adjustments，the OR even increased. Women with low UA levels appeared to be more susceptible to IM. For example，the crude OR in quartile 1 were 24.000 and 52.500 for men and women，respectively，and the respective adjusted OR were 31.437 and 301.746（all P<0.01）. Conclusion: UA is negatively correlated with IM，suggesting a progressive decrease of antioxidant reserve in IM，particularly in women.

参考文献/References:

[1] Luzuriaga K，Sullivan J L. Infectious mononucleosis[J]. N Engl J Med，2010，362（21）：1993
[2] Zhang Q，Lou S，Meng Z，et al. Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese[J]. Clin Rheumatol，2011，30（6）：777
[3] Zhang J，Meng Z，Zhang Q，et al. Gender impact on the correlations between subclinical thyroid dysfunction and hyperuricemia in Chinese[J]. Clin Rheumatol，2016，35（1）：143
[4] Llull L，Amaro S，Chamorro ?魣. Administration of uric acid in the emergency treatment of acute ischemic stroke[J]. Curr Neurol Neurosci Rep，2016，16（1）：4
[5] Moccia M，Lanzillo R，Costabile T，et al. Uric acid in relapsing-remitting multiple sclerosis：a 2-year longitudinal study[J]. J Neurol，2015，262（4）：961
[6] Collazos J，Blanco M S，Guerra E，et al. Sequential evaluation of serum urate concentrations in AIDS patients with infections of the central nervous system[J]. Clin Chem Lab Med，2000，38（12）：1293
[7] Dylewski J S，Gerson M. Hyperuricemia in patients with infectious mononucleosis[J]. Can Med Assoc J，1985，132（10）：1169
[8] Cowdrey S C. Hyperuricemia in infectious mononucleosis[J]. JAMA，1966，196（4）：319
[9] Sugita K，Hagisawa S，Satoh Y，et al. Recurrent hepatosplenomegaly and peripheral blood cytopenia，persistent Epstein-Barr virus infection and central nervous system manifestation in a patient with lymphadenopathy and low serum uric acid[J]. Acta Paediatr Jpn，1998， 40（4）：362
[10] Wu X W，Muzny D M，Lee C C，et al. Two independent mutational events in the loss of urate oxidase during hominoid evolution[J]. J Mol Evol，1992，34（1）：78
[11] Santos C X，Anjos E I，Augusto O. Uric acid oxidation by peroxynitrite：multiple reactions，free radical formation，and amplification of lipid oxidation[J]. Arch Biochem Biophys，1999，372（2）：285
[12] Zhang X，Huang Z C，Lu T S，et al. Prognostic significance of uric acid levels in ischemic stroke patients[J]. Neurotox Res，2016，29（1）：10
[13] Checconi P，Salzano S，Bowler L，et al. Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation，influenza virus infection and oxidative stress[J]. PLoS One，2015，10（5）：e0127086
[14] Zuwala-Jagiello J，Warwas M，Pazgan-Simon M. Ischemia-modified albumin （IMA） is increased in patients with chronic hepatitis C infection and related to markers of oxidative stress and inflammation[J]. Acta Biochim Pol，2012，59（4）：661
[15] Komaravelli N，Casola A. Respiratory viral infections and subversion of cellular antioxidant defenses [J]. J Pharmacogenomics Pharmacoproteomics，2014，5（4）：1000141
[16] Ngondi J L，Oben J，Forkah D M，et al. The effect of different combination therapies on oxidative stress markers in HIV infected patients in Cameroon[J]. AIDS Res Ther，2006，3（1）：19
[17] Chakraborty S P，Das S，Chattopadhyay S，et al. Staphylococcus aureus infection induced redox signaling and DNA fragmentation in T-lymphocytes：possible ameliorative role of nanoconjugated vancomycin[J]. Toxicol Mech Methods，2012，22（3）：193
[18] Kanellis J，Kang D H. Uric acid as a mediator of endothelial dysfunction，inflammation，and vascular disease[J]. Semin Nephrol，2005， 25（1）：39
[19] Hébert-Schuster M，Borderie D，Grange P A，et al. Oxidative stress markers are increased since early stages of infection in syphilitic patients [J]. Arch Dermatol Res，2012，304（9）：689

相似文献/References:

[1]陈 宪,周 蕾,庞 杰,等.血尿酸与系统性红斑狼疮患者肾损害的关系[J].天津医科大学学报,2014,20(01):42.
　CHEN Xian,ZHOU Lei,PANG Jie,et al.Association of serum uric acid with lupus nephritis in systemic lupus erythematosus patients[J].Journal of Tianjin Medical University,2014,20(01):42.
[2]陈 琳,袁如玉.冠心病患者血清胆红素、血尿酸水平与冠状动脉钙化的关系[J].天津医科大学学报,2015,21(02):134.
[3]任 彦,陆 伟.T淋巴细胞亚群检测对成人传染性单核细胞增多症的临床意义[J].天津医科大学学报,2016,22(01):62.
[4]吴 洁,刘长山.儿童传染性单核细胞增多症伴肝功能损害的相关临床因素分析[J].天津医科大学学报,2017,23(03):224.
[5]石琳,刘房春,张健,等.血尿酸及D-二聚体水平对急性心肌梗死合并心力衰竭的近期预后价值探讨[J].天津医科大学学报,2022,28(06):643.
　SHI Lin,LIU Fang-chun,ZHANG Jian,et al.The value of serum uric acid and D-dimer levels in the short-term prognosis of acute myocardial infarction complicated with heart failure[J].Journal of Tianjin Medical University,2022,28(01):643.

备注/Memo

备注/Memo:

作者简介 张丽（1976-），女，主管护师，研究方向：感染性疾病；E-mail:zhangli9920@126.com。

常用功能

更新日期/Last Update: 2021-01-10