|本期目录/Table of Contents|

[1]吴楚姗 综述,郑荣秀 审校.黏膜相关恒定T细胞（MAIT）在糖尿病发生发展中的作用研究进展[J].天津医科大学学报,2020,26(03):284-287.
点击复制

黏膜相关恒定T细胞（MAIT）在糖尿病发生发展中的作用研究进展(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
26卷
期数:
2020年03期
页码:
284-287
栏目:
综述
出版日期:
2020-06-10

文章信息/Info

Title:
-
文章编号:
1006-8147(2020)03-0284-04
作者:
吴楚姗 综述; 郑荣秀 审校
（天津医科大学总医院儿科，天津300052）
Author(s):
-
关键词:
黏膜相关恒定T细胞; MR1; 糖尿病; 胰岛β细胞; 肠道菌群
Keywords:
-
分类号:
R587.1
DOI:
-
文献标志码:
A
摘要:
黏膜相关恒定T细胞（MAIT）是一种表达半恒定T细胞受体的固有类免疫T细胞，它在人体抵御病原微生物感染、炎症性疾病、自身免疫性疾病的病理过程中扮演重要角色。糖尿病的致病主要是自身免疫、胰岛素抵抗等最终导致胰岛β细胞功能衰竭，胰岛素分泌绝对及相对不足。MAIT细胞在正常情况下对维持肠道黏膜稳态起重要作用，在糖尿病中，MAIT细胞被不适当激活，可迁移至胰岛组织释放细胞因子杀伤胰岛β细胞，同时可以激活细胞免疫过程。在2型糖尿病中，MAIT细胞还可迁移到脂肪组织中，引起脂肪组织的慢性炎症。同时MAIT细胞与肠道菌群密切相关。
Abstract:
-

参考文献/References:

[1] Lantz O，Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans[J]. J Exp Med，1994，180(3):1097
[2] Tilloy F，Treiner E，Park S，et al. An invariant T cell receptor Α chain defines a novel Tap-independent major histocompatibility complex class Ib-restricted Α/Β T cell subpopulation in mammals[J]. J Exp Med，1999，189(12):1907
[3] Porcelli S，Yockey C E，Brenner M B，et al. Analysis of T cell antigen receptor(Tcr)expression by human peripheral blood Cd4-8-alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant Tcr alpha chain[J]. J Exp Med，1993，178(1):1
[4] Chiba A，Murayama G，Miyake S. Mucosal-associated invariant T cells in autoimmune diseases[J]. Front Immunol，2018，9:1333
[5] Gibbs A，Leeansyah E，Introini A，et al. MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation[J]. Mucosal Immunol，2017，10(1):35
[6] Keller A N,Corbett A J,Wubben J M, et al. MAIT cells and Mr1-antigen recognition[J]. Curr Opin Immunol，2017，46:66
[7] Kjer-Nielsen L，Patel O, Corbett A J, et al. Mr1 presents microbial vitamin B metabolites to Mait cells[J]. Nature，2012，491(7426):717
[8] Huang S，Gilfillan S，Cella M，et al. Evidence for Mr1 antigen presentation to mucosal-associated invariant T cells[J]. J Biol Chem，2005，280(22):21183
[9] Jahreis S，Boettcher S，Hartung S，et al. Human MAIT cells are rapidly activated by Aspergillus spp. in an APC-dependent manner[J]. Eur J Immunol，2018，48(10):1698
[10] Kurioka A， Ussher J E，Cosgrove C，et al. MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets[J]. Mucosal Immunol，2015，8(2):429
[11] Dusseaux M，Martin E，Serriari N，et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells[J].Blood，2011，117(4):1250
[12] Martin E，Treiner E，Duban L，et al. Stepwise development of MAIT cells in mouse and human[J]. PLoS Biol，2009，7(3):e54
[13] Koay H F, Godfrey D I, Pellicci D G. Development of mucosal-associated invariant T cells[J]. Immunol Cell Biol，2018，96(6):598
[14] Le Bourhis L，Martin E，Péguillet I，et al. Antimicrobial activity of mucosal-associated invariant T cells[J]. Nat Immunol，2010，11(8):701
[15] Treiner E，Duban L，Bahram S，et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by Mr1[J]. Nature，2003，422 (6928):164
[16] Rouxel O，Da Silva J，Beaudoin L，et al. Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes[J].Nat Immunol，2017，18(12):1321
[17] Hinks T S. Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease[J]. Immunology，2016，148 (1):1
[18] Wong E B，Ndung’u T，kasprowicz V O. The role of Mucosal-associated invariant T cells in infectious diseases[J]. Immunology，2017， 150(1):45
[19] Loh L，Wang Z F，Sant S，et al. Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation[J]. Proc Natl Acad Sci U S A，2016，113(36):10133
[20] van Wilgenburg B，Scherwitzl I，Hutchinson E C，et al. MAIT cells are activated during human viral infections[J]. Nat Commun，2016，7:11653
[21] Leeansyah E，Svard J，Dias J，et al. Arming of MAIT cell cytolytic antimicrobial activity is induced by IL-7 and defective in HIV-1 infection[J]. PLoS Pathog，2015，11(8):e1005072
[22] Rouxel O，Lehuen A. Mucosal-associated invariant T cells in autoimmune and immune-mediated diseases[J]. Immunol Cell Biol，2018，96(6):618
[23] Toubal A，Nel I，Lotersztajn S，et al. Mucosal-associated invariant T cells and disease[J]. Nat Rev Immunol，2019，19（10）：643
[24] Godfrey I D，Koay H F，Mccluskey J，et al. The biology and functional importance of MAIT cells[J]. Nat Immunol，2019，20(9):1110
[25] Gale E A. Type 1 diabetes in the young: the harvest of sorrow goes on[J]. Diabetologia，2005,48(8):1435
[26] Xia Y，Xie Z G，Huang G，et al. Incidence and trend of type 1 diabetes and the underlying environmental determinants[J]. Diabetes Metab Res Rev，2019，35(1):e3075
[27] Kahaly G J，Hansen M P. Type 1 diabetes associated autoimmunity[J]. Autoimmun Rev, 2016，15(7):644
[28] Canivell S, Gomis R. Diagnosis and classification of autoimmune diabetes mellitus[J]. Autoimmun Rev，2014,13(4/5):403
[29] Atkinson M A，Eisenbarth G S，Michels A W. Type 1 diabetes[J]. Lancet, 2014，383(9911):69
[30] Rahimpour A，Koay H F，Enders A，et al. Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using Mr1 tetramers[J]. J Exp Med，2015，212(7):1095
[31] Petersone L，Walker L S. MAIT cells in type 1 diabetes: a good friend turned bad[J]. Nat Immunol，2017，18(12):1283
[32] Zipris D. The interplay between the gut microbiota and the immune system in the mechanism of type 1 diabetes[J]. Curr Opin Endocrinol Diabetes Obes，2013, 20(4):265
[33] Giongo A，Gano K A，Crabb D B, et al. Toward defining the autoimmune microbiome for type 1 diabetes[J]. ISME J，2011，5(1):82
[34] De Goffau M C, Luopajarvi K, Knip M A, et al. Fecal microbiota composition differs between children with β-cell autoimmunity and those without[J]. Diabetes，2013，62(4):1238
[35] Endesfelder D，Castell W Z，Ardissone A，et al. Compromised gut microbiota networks in children with anti-islet cell autoimmunity[J]. Diabetes，2014，63(6):2006
[36] O’brien A，Loftus R M，Pisarska M M，et al. Obesity reduces mtorc1 activity in mucosal-associated invariant T cells，driving defective metabolic and functional responses[J]. J Immunol，2019，202(12):3404
[37] Carolan E，Tobin L M，Mangan B A，et al. Altered distribution and increased IL-17 production by mucosal-associatedinvariant T cells in adult and childhood obesity[J]. J Immunol，2015，194(12):5775
[38] Zuniga L A，Shen W J，Joyce-Shaikh B，et al. IL-17 regulates adipogenesis, glucosehomeostasis, and obesity[J]. J Immunol，2010,185(11): 6947

相似文献/References:

备注/Memo

备注/Memo:
基金项目 国家重点研发计划重大慢性非传染型疾病防控研究项目资助（2016YFC1305301）；天津市卫计委重点攻关研究项目资助（16KG123）；天津市自然科学基金重点项目资助（17JCZDJC36400）；天津医科大学总医院孵育基金资助（ZYYFY2016018）；天津市科技局科学技术普及活动项目资助（18KPHDSF00140）
作者简介 吴楚姗（1993-），女，博士在读，研究方向：儿童内分泌；通信作者：郑荣秀，E-mail：18622815720@163.com。
更新日期/Last Update: 2020-06-13