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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

26卷

期数:

2020年02期

页码:

158-162,174

栏目:

临床医学

出版日期:

2020-04-30

文章信息/Info

Title:

Early diagnostic value of lipopolysaccharide binding protein combined with procalcitonin and interleukin -6 on the bacterial infection of preterm infants with premature rupture of membranes

文章编号:

1006-8147(2020)02-0163-04

作者:

饶红萍¹; 李易娟²

（1.惠州市中心人民医院，惠州 516001；2.中山大学附属第一医院，广州 510080）

Author(s):

RAO Hong-Ping¹;  LI Yi-Juan²

（1. Department of Neonatology, Cenrtral People’s Hospital of Huizhou City , Huizhou 516001, China；2. Department of Pediatrics, The First Affiliated Hospital ,Zhongshan University，Guangzhou 510080， China）

关键词:

脂多糖结合蛋白; 降钙素原; 白细胞介素-6; 胎膜早破; 早产儿; 细菌性感染

Keywords:

lipopolysaccharide binding protein; procalcitonin;  interleukin-6; premature rupture of membranes; premature infant;  bacterial infection

分类号:

R722.6

DOI:

-

文献标志码:

A

摘要:

目的：评估脂多糖结合蛋白（LBP）、降钙素原（PCT）和白细胞介素-6（IL- 6）在胎膜早破（PROM）合并细菌感染的早产儿诊断价值。方法：选取93例入住惠州市中心人民医院新生儿科的PROM早产儿。根据是否发生细菌感染（生后72 h内），分为感染组（45例）和非感染组（48例），于出生后24 h内取血，测定血清LBP、PCT和IL-6的水平，通过联合绘制受试者工作特征（ROC）曲线，计算曲线下面积（AUC）。LBP、PCT和IL-6中两组的组合指标与每个指标比较，评估联合指标在预测PROM早产儿早期细菌感染的诊断价值。结果：LBP和PCT、LBP和IL-6、PCT和IL-6在诊断PROM早产儿早期细菌感染诊断中的AUC分别为0.976、0.977和0.728。LBP/PCT与PCT、LBP/IL-6与IL-6、PCT/IL-6与PCT、PCT/IL-6与IL-6在AUC值上有显著性差异。LBP/PCT与LBP、LBP/IL-6与LBP的AUC值比较差异无统计学意义。结论：联合检测LBP、PCT、IL-6可提高PROM早产儿细菌感染的早期诊断价值。

Abstract:

Objective: To evaluate the diagnostic value of lipopolysaccharide binding protein (LBP) combined with procalcitonin (PCT) and interleukin -6(IL-6) in bacterial infection in preterm infants with premature rupture of membranes(PROM). Methods: 93 cases preterm infants of PROM in Huizhou Central People’s Hospital were collected. Premature infants were divided into infection group(45 cases) and non-infection group(48 cases) according to the diagnostic criteria within 72 hours after birth. The serum levels of LBP, PCT and IL-6 were detected within 24 hours after birth. Receiver operator characteristic(ROC)curve was jointly drawn and area under the curve (AUC) was calculated. The combined indexes of LBP , PCT and IL-6 were compared with each index. The diagnostic value of combined indexes in early bacterial infection in preterm infants with PROM were evaluated. Results: Diagnosis of early bacterial infection in preterm infants with PROM by combined index showed that the AUC of ROC for LBP and PCT, LBP and IL-6, PCT and IL-6 were 0.976，0.977，0.728, respectively. The result of AUC was significant difference between LBP/PCT and PCT, LBP/IL-6 and IL-6, PCT/IL-6 and PCT, PCT/IL-6 and IL-6. The result of AUC was no significant difference between LBP/PCT and LBP, LBP/IL-6 and LBP. Conclusion: Combined detection of LBP, PCT and IL-6 can improve the early diagnostic value of early bacterial infection in premature infants with PROM.

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备注/Memo

备注/Memo:

作者简介 饶红萍（1981-），女，副主任医师，硕士，研究方向：新生儿学；
通信作者:李易娟，E-mail：liyijuansums@126.com。

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更新日期/Last Update: 2020-06-02