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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年06期

页码:

572-576

栏目:

临床医学

出版日期:

2019-11-20

文章信息/Info

Title:

Application value of Apelin-13 in the clinical diagnosis of coronary arteriosclerosis

文章编号:

1006-8147(2019)06-0572-05

作者:

孙旭森¹; 2; 张宇凡¹; 2; 李沅洋²; 3; 齐 新²; 魏丽萍²

（1.天津医科大学研究生院，天津300070；2.天津市人民医院心脏内科，天津300121；3.天津中医药大学，天津 300073）

Author(s):

SUN Xu-sen¹; 2 ;  ZHANG Yu-fan ¹; 2;  LI Yuan-yang²; 3;  QI Xin²;  WEI Li-ping²

（1. Graduate School, Tianjin Medical University,Tianjin 300070,China; 2. Department of Cardiology, Tianjin Union Medical Center, Tianjin 300121, China; 3. Tianjin University of Traditional Chinese Medicine,Tianjin 300073, China)

关键词:

Apelin-13; 动脉粥样硬化; 冠状动脉疾病

Keywords:

Apelin-13; atherosclerosis; coronary artery disease

分类号:

R541.4

DOI:

-

文献标志码:

A

摘要:

目的：探讨血清中Apelin-13水平与冠状动脉粥样硬化病变程度的相关性及在临床诊断中的应用价值。方法：随机选取我院心内科125例具有不同程度冠状动脉粥样硬化病变的患者作为实验组，同时选取37例冠状动脉粥样正常的患者作为对照组。收集患者一般临床资料以及生化指标，检测血清Apelin-13水平。应用Pearson相关分析Apelin-13与冠状动脉粥样硬化病变程度相关性。通过ROC曲线得到Apelin-13的最佳截断值。结果：所选取各组的基线特征在年龄、BMI、血压、血糖等方面均无显著统计学差异（P>0.05）。血清Apelin-13的水平与冠状动脉病变程度（Gensini评分）呈负相关（r=-0.523，P<0.05）。通过绘制ROC曲线，得到Apelin-13诊断急性冠脉综合征的最佳截断值为2.15 ng/mL。结论：血清Apelin-13水平与冠状动脉硬化病变程度呈负相关。Apelin-13有望成为急性冠脉综合征临床诊断的一种新型血清标志物。

Abstract:

Objective: To explore the correlation between serum Apelin-13 level and the degree of coronary atherosclerosis and its clinical value in diagnosis of coronary atherosclerosis. Methods: 125 patients with varying degrees of coronary arteriosclerosis in the department of cardiology of our hospital were randomly selected as the experimental group, and 37 patients with normal or only slight coronary artery sclerosis were selected as the control group.The general clinical data and biochemical indexes of the patients were collected, and the serum Apelin-13 level was detected.Pearson correlation was used to analyze the correlation between Apelin-13 and the severity of coronary arteriosclerosis.The best truncation value of Apelin-13 was obtained by ROC curve. Results: The baseline characteristics of the selected groups showed no significant difference in age, BMI, blood pressure and blood glucose (P>0.05).The serum Apelin-13 level was negatively correlated with the degree of coronary artery disease (Gensini score) (r=-0.523, P <0.05). By drawing the ROC curve, the optimal truncation value of Apelin-13 for the diagnosis of acute coronary syndrome is 2.15 ng/mL. Conclusion: The serum Apelin-13 level is negatively correlated with the degree of coronary arteriosclerosis.Apelin-13 is expected to become a new serum marker in the clinical diagnosis of acute coronary syndrome.

参考文献/References:

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相似文献/References:

备注/Memo

备注/Memo:

基金项目 国家自然科学基金青年科学基金项目（81200158）；天津市卫计委科技攻关项目（16KG155）；天津市科委慢性疾病防治科技重大专项（16ZXMJSY00060）
作者简介 孙旭森（1992-），男，硕士在读，研究方向：冠心病的临床与基础研究；通信作者：魏丽萍，E-mail：rmyywlp@163.com。

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更新日期/Last Update: 2020-01-20