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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年02期

页码:

147-149

栏目:

临床医学

出版日期:

2019-03-20

文章信息/Info

Title:

Clinical significance of FeNO and peripheral blood eosinophil ratio in children with Mycoplasma pneumoniae pneumonia

文章编号:

1006-8147(2019)02-0147-03

作者:

张 奕; 刘长山

（天津医科大学第二医院儿科，天津300211）

Author(s):

ZHANG Yi;  LIU Chang-shan

（Department of Paediatrics, The Second Hospital, Tianjin Medical University, Tianjin 300211, China）

关键词:

肺炎支原体肺炎; 嗜酸性粒细胞; 呼出气一氧化氮; 肺功能; 儿童

Keywords:

Mycoplasma pneumoniae pneumonia;  eosinophil;  FeNO;  lung function; children

分类号:

R725

DOI:

-

文献标志码:

A

摘要:

目的：探讨呼出气一氧化氮（FeNO）及外周血嗜酸性粒细胞（EOS）水平在儿童肺炎支原体肺炎（MPP）中的临床意义。方法：选择2015年4月-2017年4月因肺炎住院治疗患儿共242例，根据肺炎支原体（MP）抗体水平分为MPP组（142例）及非MPP组（100例），比较各组间FeNO、EOS、血清总IgE（TIgE）水平、肺功能及临床特点。结果：MPP组较非MPP组FeNO及EOS比例升高，但TIgE水平无统计学差异，肺功能中呼气峰流速值（PEF）、用力呼气流量50%及75%（MEF50，MEF75）占预计值百分比降低。MPP组影像学表现肺部实变影较多，易出现胸腔积液,肺功能受损及影像学改变与外周血EOS水平相关。结论：儿童MPP可出现FeNO水平及外周血EOS比例增高，外周血EOS水平可能影响MP感染后肺功能及影像学临床表现。

Abstract:

Objective: To investigate clinical significance of Fractional exhaled nitric oxide (FeNO) and peripheral blood eosinophils (EOS) levels in children with Mycoplasma pneumoniae pneumonia (MPP). Methods: Two hundred and forty-two cases of hospitalized children with pneumonia from April 2015 to April 2017 were included and divided into MPP group (142 cases) and non-MPP group (100 cases) according to the antibody level of Mycoplasma pneumoniae (MP), and FeNO, EOS, serum total IgE (TIgE) level, lung function. Clinical characteristics in each group were compared. Results: Compared with the non-MPP group, FeNO and EOS of the MPP group was increased, but no difference was found in TIgE, and lung function was reduced. MPP group was prone to lobar consolidation and pleural effusion. Impaired lung function and imaging changes were associated with peripheral blood EOS levels. Conclusion: EOS and FeNO level may increase in children with MPP. The peripheral blood EOS ratio may affect lung function and imaging findings after MP infection.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目 天津医科大学科学基金（2014KYQ25） 作者简介 张奕（1983-）女，主治医师，硕士，研究方向：儿科；E-mail： kyzz3347@163.com。

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更新日期/Last Update: 2019-04-25