|本期目录/Table of Contents|

[1]刘轩慧,王 倩,骆宏亮,等.初步探索NICU患者血红蛋白和红细胞比容测定值与多蛋白水平的关系[J].天津医科大学学报,2019,25(02):128-131.
　LIU Xuan-hui,WANG Qian,LUO Hong-liang,et al.Preliminary exploration on the correlation between levels of hemoglobin/ hematocrit and multi-proteins in the serum of NICU patients[J].Journal of Tianjin Medical University,2019,25(02):128-131.
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初步探索NICU患者血红蛋白和红细胞比容测定值与多蛋白水平的关系(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年02期
页码:
128-131
栏目:
临床医学
出版日期:
2019-03-20

文章信息/Info

Title:
Preliminary exploration on the correlation between levels of hemoglobin/ hematocrit and multi-proteins in the serum of NICU patients
文章编号:
1006-8147(2019)02-0128-04
作者:
刘轩慧; 王 倩; 骆宏亮; 安 硕; 郭林月; 田 野; 魏盈胜; 孙 健; 江荣才
（天津医科大学总医院神经外科，天津市神经病学研究所，天津300052）
Author(s):
LIU Xuan-hui; WANG Qian; LUO Hong-liang; AN Shuo; GUO Lin-yue ; TIAN Ye; WEI Ying-sheng; SUN Jian; JIANG Rong-cai
（Department of Neurosurgery and Tianjin Neurological Institute, General Hospital, Tianjin Medical University, Tianjin 300052，China）
关键词:
营养; 蛋白; 血红蛋白; 红细胞比容
Keywords:
Nutrition;  Protein;  Hemoglobin;  Hematocrit
分类号:
R651.1+9
DOI:
-
文献标志码:
A
摘要:
目的：初步探索以神经外科重症监护病房（NICU）患者常见临床化验指标血红蛋白（HB）、红细胞比容（HCT）判断患者多种营养相关蛋白水平的可能性。方法：前瞻性纳入2017年8月-11月天津医科大学总医院NICU收治的急性脑损伤患者43例。采集入组第1天及第7天的血液标本并测评第7天APACHE II评分和SOFA评分，同步检测患者HB、HCT、白蛋白（ALB），前白蛋白（PA）和转铁蛋白（TR）水平，分析HB与HCT与ALB、PA、TR之间测定值及变化值的相关关系，以及HB、HCT分别与APACHE II评分和SOFA评分之间的相关关系。也记录同步检测的动脉血血气分析中HB和HCT值，分析它们与静脉血检测值相关关系。同时，对HB与HCT测定值之间相关关系也进行分析。结果：患者入组1 d和7 d的HB和HCT的测定值与同时间点ALB、PA和TR的测定值均呈正相关（r=0.521，P=0.000；r=0.306，P=0.004；r=0.420，P=0.000），且它们的变化值同样也呈正相关（r=0.581， P=0.000；r=0.496，P=0.001；r=0.527，P=0.000），同时HB、HCT与患者APACHE II评分和SOFA评分呈负相关（r =-0.735，P=0.000；r=-0.607，P=0.005）。HCT与HB实测值之间呈正相关（r=0.942，P=0.000），动静脉血所测得的HB/HCT值之间呈正相关（r=0.960，P=0.000；r=0.964，P=0.000）。结论：NICU临床常规检测的HB和HCT测定值可代表多蛋白水平，具有临床实用价值。
Abstract:
Objective: To explore the relationship between the levels of multiple nutrition related proteins with common clinical test indexes of hemoglobin（HB） and hematocrit（HCT）. Methods：A prospective study was conducted from August 2017 to November 2017. Forty-three inpatients who suffered from acute cerebral injury in the Neurosurgical Intensive Care Unit（NICU） in Tianjin Medical University General Hospital were enrolled. The blood samples were collected from each enrolled patients on day 1 and day 7 after they were admitted. Meanwhile， APACHE II score and SOFA score were assessed on day 7. The levels of HB， HCT, albumin（ALB）, prealbumin（PA） and transferrin（TR） were all measured. Then the correlation analysis between these values and their trend were performed. Meanwhile HB/ HCT data of the arterial blood samples was recorded from the blood gas analysis results. The correlations between HB/HCT data of venous and arterial blood samples were also analyzed. At the same time，The correlation between HB and HCT was analyzed Results：There was a significant positive correlation between detection values of HB/HCT and values of Alb， PA and TR （r=0.521，P=0.000；r=0.306，P=0.004；r=0.420，P=0.000）on day 1 and on day 7 after admission. Changes in values were also significantly and positively correlated（r=0.581，P=0.000；r=0.496，P=0.001；r=0.527，P=0.000）. Moreover，there were negative correlations between HB /HCT and APACHE II score and between HB/HCT and SOFA score respectively（r=-0.735，P =0.000；r=-0.607，P=0.005）. Positive correlation between HCT and HB was showed（r=0.942，P=0.000）.The HB/HCT data of venous was significantly positively correlated with that of arterial blood samples （r=0.960，P=0.000；r=0.964，P=0.000）. Conclusion：The clinical routine testing results of HB or HCT in NICU may be used to indicate levels of multi-proteins of NICU patients, with significant clinical value in practice.

参考文献/References:


[1] Bouharras-Elidrissi H， Molina-L?仵pez J，Herrera-Quintana，et al. Prognostic value of severity by various visceral proteins in critically ill patientswith SIRS during 7 days of stay[J]. Nutr Hosp，2016，33（6）:1276
[2] Stanojcic M， Finnerty C C， Jeschke M G. Anabolic and anticatabolic age-nts in critical care [J]. Curr Opin Crit Care， 2016，22（4）:325
[3] 丛丽，黄海燕，喻姣花.ICU患者诊断性失血的研究进展[J].中华护理杂志，2011，（2）:197
[4] Schaffer C. Diagnostic blood loss in mechanically ventilated patients[J]．Heart Lung，2007，36（3）：217
[5] 张英英，朱红珍，陈春英， 等. ICU病人诊断性采血失血量的调查研究[J].护理研究，2014，（30）:3722
[6] Delliere S， Cynober L. Is transthyretin a good marker of nutritional Status [J]. Clin Nutr， 2017， 36（2）:364
[7] Ferrie S， Allman-farinelli M. Commonly used nutrition indicators do not predict outcome in the critically Ill a systematic review [J]. Nutr Clin Pract， 2013， 28（4）:463
[8] Boles J M， Garre M A， Youinou P Y， et al. Nutritional status in intensive care patients: evaluation in 84 unselected patients[J]. Crit Care Med， 1983， 11（2）:87
[9] Pinilla J C， Hayes P， Laverty W， et al. The C-reactive protein to prealbumin ratio correlates with the severity of multiple organ dysfunction [J].Surgery， 1998， 124（4）:799
[10] NisimI A， Allins A D. Enteral nutritional support [J]. Nutrition，2005， 21:109
[11] Sungurtekin K， Sungurtekin U， Oner O， et al. Nutrition assessment in critically ill patients [J]. Nutr Clin Pract， 2008， 23（6）:635
[12] 黄耿，刘岩. 血清前白蛋白水平与营养评价[J]. 中国医师杂志，2010，（z1）:283
[13] 刘开俊，郑国寿，宋先舟，等. 颅脑损伤后蛋白质代谢和免疫功能的变化及意义[J].创伤外科杂志，2004（4）:260
[14] Lee J，Cho Y J，Kim S J， et al. Who dies after ICU discharge Retrospective analysis of prognostic factors for in-hospital mortality of ICU survivors [J]. J Korean Med Sci， 2017， 32（3）:528
[15] 张泓，张磊，李磊， 等.血红蛋白在外科危重病中的变化及其意义[J].中华外科杂志，2009（16）:1221

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目（81671221）；天津市科技支撑项目（14ZCZDSY00179）；天津医科大学临床医学研究项目 (2017kylc007 ) 作者简介 刘轩慧（1992-），男，硕士在读，研究方向：神经外科；通信作者：江荣才，E-mail:jiang116216@163.com。
更新日期/Last Update: 2019-04-25