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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年03期

页码:

201-204

栏目:

出版日期:

2018-05-20

文章信息/Info

Title:

Study on the effect of phospholipid complex on the gastrointestinal irritation of aspirin in rats

作者:

刘勃缨¹; 2; 姜双瑜³; 李新悦¹; 2; 吴玉梅¹; ²; 张瀛¹; 2; 徐松林³

1.天津中医药大学，现代中药发现与制剂技术教育部工程中心，天津300193；2.天津中医药大学，天津市现代中药重点实验室-省部共建国家重点实验室培育基地，天津300193；3.浙江海昶生物医药技术有限公司，杭州 310000

Author(s):

LIU Bo-ying¹; 2; JIANG Shunng-yu³;  LI Xin-yue¹; 2;  WU Yu-mei¹; 2;  ZHANG Ying¹; 2;  XU Song-Lin³

1.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique， Ministry of Education， Tianjin University of Traditional Chinese Medicine， Tianjin 300193，China; 2. Tianjin State Key Laboratory of Modern Chinese Medicine， Tianjin 300193, China; 3.Zhejiang Haichang Biopharm CO. Ltd., Hangzhou 310000, China

关键词:

阿司匹林; 磷脂复合物; 胃肠道刺激性; 大鼠

Keywords:

aspirin;  phospholipid complex;  gastrointestinal irritation;  rat

分类号:

R9

DOI:

-

文献标志码:

A

摘要:

目的：研究磷脂复合物改善阿司匹林对大鼠胃肠道刺激性的作用。方法：取健康雄性SD大鼠，分为4组，每组10只，分别给予生理盐水、阿司匹林片剂、阿司匹林磷脂复合物和阿司匹林磷脂复合物胶囊。实验前大鼠禁食12 h，每日灌胃1次，连续给药（300 mg/kg）14 d，14 d后颈椎脱臼法处死动物并解剖取胃，进行HE染色制作病理组织切片，观察胃部损伤情况。结果：阿司匹林磷脂复合物组的胃组织无明显病变，其胃损伤情况明显低于阿司匹林普通片剂组（P<0.05）。结论：磷脂复合物能有效改善阿司匹林对胃肠道的刺激性。

Abstract:

Objective: To study the effect of phospholipid complex on alleviating aspirin induced gastrointestinal irritant in rats. Methods：Forty healthy male SD rats were randomly divided into four groups and respectively given the normal saline, aspirin tablets, aspirin phospholipid complex and aspirin phospholipid complex capsules. After 12 hours of fasting, the rats were administered an oral dose of aspirin (300 mg/kg body weight) for 14 days. The animals were sacrificed via cervical decapitation, and the stomach was dissected. HE staining was performed on pathological tissue section to observe the injury to the stomach. Results：There was no obvious lesion in the gastric tissue of aspirin phospholipid complex, and the gastric damaging effect of aspirin was found significantly lower in the group of the animal with aspirin phospholipid complex than with aspirin tablets. Conclusion：The aspirin phospholipid complex can effectively reduce the gastrointestinal irritation induced by aspirin and has excellent gastric protective effect.

参考文献/References:

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相似文献/References:

[1]田珺琪,张志广,李 熳,等.双联抗血小板药物对大鼠小肠的损伤及其机制[J].天津医科大学学报,2014,20(05):0.
　TIAN Jun-qi,ZHANG Zhi-guang,LI Man,et al.Dual antiplatelet drugs-induced small intestinal injury and its possible mechanism in rats[J].Journal of Tianjin Medical University,2014,20(03):0.
[2]田珺琪,张志广,李 熳,等.双联抗血小板药物对大鼠小肠的损伤及其机制[J].天津医科大学学报,2014,20(05):0.
　TIAN Jun-qi,ZHANG Zhi-guang,LI Man,et al.Dual antiplatelet drugs-induced small intestinal injury and its possible mechanism in rats[J].Journal of Tianjin Medical University,2014,20(03):0.
[3]田珺琪,张志广,李 熳,等.双联抗血小板药物对大鼠小肠的损伤及其机制[J].天津医科大学学报,2014,20(05):350.
　TIAN Jun-qi,ZHANG Zhi-guang,LI Man,et al.Dual antiplatelet drugs-induced small intestinal injury and its possible mechanism in rats[J].Journal of Tianjin Medical University,2014,20(03):350.
[4]田珺琪,张志广,李 熳,等.双联抗血小板药物对大鼠小肠的损伤及其机制[J].天津医科大学学报,2014,20(05):350.
　TIAN Jun-qi,ZHANG Zhi-guang,LI Man,et al.Dual antiplatelet drugs-induced small intestinal injury and its possible mechanism in rats[J].Journal of Tianjin Medical University,2014,20(03):350.

备注/Memo

备注/Memo:

文章编号 1006-8147(2018)03-0201-04
作者简介 刘勃缨（1992-），女，硕士在读，研究方向：中药药剂学；通信作者：刘志东，E-mail:lonerliuzd@163.com。

常用功能

更新日期/Last Update: 2018-05-20