«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年02期

页码:

152-155

栏目:

出版日期:

2018-03-20

文章信息/Info

Title:

Expression and significance of serum inflammatory cytokines and chemokines in patients with viral hepatitis B

作者:

赵小丽; 高鹏; 刘俊华; 周凤蕊; 王佳乐; 李广明

郑州市第六人民医院肝病五科，郑州 450061

Author(s):

ZHAO Xiao-li;  GAO Peng;  LIU Jun-hua;  ZHOU Feng-rui;  WANG Jia-le;  LI Guang-ming

Five Department of Liver Disease, The Sixth People’s Hospital of Zhengzhou, Zhengzhou 450061, China

关键词:

炎症因子; 趋化因子; 乙肝; 生化指标

Keywords:

inflammatory factor;  chemokine;  hepatitis B;  biochemical markers

分类号:

R575.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨血清炎症因子（IL-6、IL-10和IL-12）及趋化因子（CXCL16和CXCL11）在乙型病毒 性肝炎（乙肝）患者体内的变化及意义。方法: 选取乙肝患者93例，其中轻度乙肝患者37例，中度乙肝 患者30例，重度乙肝患者26例，同时选取40例健康志愿者作为对照组，检测各组炎症因子（IL-6、IL-10 和IL-12）、趋化因子（CXCL16和CXCL11）和生化指标（AST、ALT、TC、TG和DBIL）。结果：轻度、中度 和重度组CXCL16和CXCL11明显高于对照组（P ＜0.05）；重度组IL-6、IL-10和IL-12明显高于轻度组、 中度组和对照组（P ＜0.05）；中度组IL-6、IL-10和IL-12明显高于轻度组和对照组（P ＜0.05）；轻 度、中度和重度组AST、ALT和DBIL明显高于对照组（P ＜0.05），而TC明显低于对照组（P ＜0.05）； 重度组HBV DNA明显高于中度和轻度组（P＜0.05）；中度组HBV DNA明显高于轻度组（P ＜0.05）；IL-6 和IL-12与ALT成正相关（r =0.404和0.434，P ＜0.05），而IL-10与ALT成负相关（r =-0.341，P ＜ 0.05）；CXCL16与生化指标无相关性（P ＞0.05）；IL-6、IL-12和IL-10与CXCL16、CXCL11无相关性（P ＞0.05）；HBV DNA与ALT、AST、CXCL16呈正相关（r =0.302、0.305和0.413，P ＜0.05）。结论：乙肝 患者IL-6、IL-10、IL-12以及CXCL16和CXCL11表达上调，其中IL-6、IL-10、IL-12和CXCL11可一定程度 反映肝功能损害程度。

Abstract:

Objective: To investigate the changes and significance of serum inflammatory factors (IL-6, IL-10 and IL-12) and chemokines (CXCL16 and CXCL11) in patients with hepatitis B. Methods: Ninety-three patients with chronic hepatitis B were selected, among them 37 mild patients, 30 moderate patients and 26 severe patients. 40 healthy volunteers were selected as control group. The inflammatory factors (IL-6, IL-10 and IL-12), chemokines (CXCL16 and CXCL11) and biochemical markers (AST, ALT, TC, TG and DBIL) were detected in each group. Results: The CXCL16 and CXCL11 of mild, moderate and severe patients were significantly higher than those of the control group (P ＜0.05). The IL-6, IL-10 and IL-12 in severe patients were significantly higher than those in the mild, moderate group and control group (P ＜0.05). The levels of IL-6, IL-10 and IL-12 in moderate group were significantly higher than those in mild group and control group (P ＜ 0.05). The levels of AST, ALT and DBIL in mild, moderate and severe patients were significantly higher than those in control group (P ＜0.05), while TC was significantly lower than that in control group (P ＜0.05). The HBV DNA in the severe group were significantly higher than those in the mild group and moderate group (P ＜0.05). The HBV DNA in the moderate group were significantly higher than those in the mild group (P ＜ 0.05). IL-6 and IL-12 were positively correlated with ALT (r =0.404 and 0.434, P ＜0.05), while IL-10 was negatively correlated with ALT(r =-0.341, P ＜0.05); CXCL11 was positively correlated with AIL (r =0.433, P ＜0.05), and CXCL16 was uncorrelated with biochemical indexes (P ＞0.05). IL-6, IL-12 and IL-10 had no correlation with CXCL16 and CXCL11(P ＞ 0.05). There was a positive correlation between HBV DNA and ALT, AST, CXCL16 (r=0.302, 0.305 and 0.413, P ＜0.05). Conclusion: The expressions of IL-6, IL-10, IL-12, CXCL16 and CXCL11 in patients with hepatitis B are up-regulated, and IL-6, IL-10, IL-12 and CXCL11 could reflect the degree of liver function damage to some extent.

参考文献/References:

[1] 刘甲野，吕静静，颜丙玉，等. 乙型肝炎病毒核心抗体单项阳性及健康的成年人乙肝疫苗免疫效 果配对比较研究[J]. 中华流行病学杂志,2014,35(10):1091
[2] 王颖,李卓,惠威,等.慢性乙型肝炎患者血清趋化因子的随访分析[J]. 北京医学,2015,37(9):888
[3] 王淑琴，王建勇，陈永谦，等. 乙型肝炎后肝硬化患者血清IL-18和IL-10水平检测的临床意义 [J]. 齐齐哈尔医学院学报, 2013(13):1894
[4] 曲孝阳,褚瑞海,武林,等.慢性乙型肝炎患者外周血趋化因子CXCL11和CXCL16的检测及意义[J]. 潍坊医学院学报,2016, 38(2):122
[5] 刘兰,汪俊华,黄文湧,等.贵州省少数民族地区乙肝防治知识、态度、行为现况调查[J]. 中华疾 病控制杂志,2015,19(11):1092
[6] Chen D F, Luo S Z, Ben Q W, et al. Prevalence of hepatitis B and C and factors for infection and nonimmune in inflammatory bowel disease patients in China[J]. Eur J Gastroenterol Hepatol, 2017, 29(5):509
[7] Chan H C, Wong V W, Wong G L, et al. Prevalence of hepatitis B and clinical outcomes in inflammatory bowel disease patients in a viral-endemic region[J]. BMC Gastroenterol, 2016,16(1):90
[8] Li M R, Lu J H, Ye L H, et al. Quantitative hepatitis B core antibody level is associated with inflammatory activity in treatment-naive chronic hepatitis B patients[J]. Medicine, 2016, 95(34):4422
[9] Isorce N, Testoni B, Locatelli M A, et al. Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus[J]. Antiviral Res, 2016,130(6):36
[10] 沈慧杰，褚瑞海，王可宁. 慢性重型乙型肝炎患者血清TNF-α,IL-10水平检测及临床意义[J]. 潍 坊医学院学报,2014,37(1):45
[11] 李德征,南月敏,闫有敏,等.慢性乙型肝炎患者血清 CCL7与 IL-6、TGF-β1表达的关系及其在肝脏 炎症／纤维化进展中作用的研究[J]. 河北医药,2014,36(13):1937
[12] 高志玲,于艳华,石莹,等.乙型肝炎患者外周血趋化因子 CXCL13表达水平与 Tfh 细胞亚群分布的 相互关系及其临床意义[J]. 中华微生物学和免疫学杂志,2016,36(5):354
[13] 邓玉奎，王勇强，武敬.慢性乙型肝炎患者血清细胞因子的检测及临床意义[J]. 广东医学院学报 ，2015，33(3):285
[14] 曾钢，李彩东，吴斌，等.乙型肝炎肝硬化患者外周血MIF,IL-17和IL-10检测的临床意义[J]. 国 际检验医学杂志，2015，36(9):1205

相似文献/References:

[1]焦国慧 综述,王邦茂,周 璐 审校.趋化因子参与自身免疫性肝病发病的研究进展[J].天津医科大学学报,2016,22(04):364.
[2]贾圣陶,张慧鲲 综述,谷峰,等.Pentraxin 3在肿瘤中作用的研究进展[J].天津医科大学学报,2021,27(06):651.
[3]来佳丹,魏诗瑶,李常颖.肾癌来源的IL4I1介导Treg诱导与募集的实验研究[J].天津医科大学学报,2023,29(03):302.
　LAI Jia-dan,WEI Shi-yao,LI Chang-ying.Research on inducement and recruitment of Treg mediated by IL4I1 derived from renal cell carcinoma[J].Journal of Tianjin Medical University,2023,29(02):302.
[4]李美,来佳丹,魏诗瑶,等.肾透明细胞癌来源的IL4I1介导PD1+CD8+ T淋巴细胞募集的相关研究[J].天津医科大学学报,2024,30(02):122.[doi:10.20135/j.issn.1006-8147.2024.02.0122]
　LI Mei,LAI Jiadan,WEI Shiyao,et al.Research on recruitment of PD1+ CD8+ T lymphocytes mediated by IL4I1 derived from clear cell renal cell carcinoma[J].Journal of Tianjin Medical University,2024,30(02):122.[doi:10.20135/j.issn.1006-8147.2024.02.0122]

备注/Memo

备注/Memo:

文章编号 １００６－８１４７（２０18）０2-0152-04
作者简介 赵小丽 (1985-),女，主治医师，学士，研究方向：肝病 ；通信作者:李广明，E-mail：sflijing1978@163.com。

常用功能

更新日期/Last Update: 2018-03-20