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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年02期

页码:

138-141

栏目:

出版日期:

2018-03-20

文章信息/Info

Title:

Correlation between clinicopathological features of papillary thyroid microcarcinoma and central compartment nodal metastasis

作者:

王猛₁; 魏玺₂; 郑向前₁; 高明₁

1.天津医科大学肿瘤医院甲状腺颈部肿瘤科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心，天津300060；2.天津医科大学肿瘤医院超声诊疗科,天津300060

Author(s):

WANG Meng₁;  WEI Xi₂;  ZHENG Xiang-qian₁;  GAO Ming₁

1.Department of Thyroid and Neck Tumor, Cancer Hospital ,Tianjin Medical University，National Clinical Research Center for Cancer，Tianjin Key Laboratory of Cancer Prevention and Therapy，Tianjin’s Clinical Research Center for Cancer，Tianjin 300060，China；2.Department of Ultrasound Diagnosis and Treatment, Cancer Hospital ,Tianjin Medical University，Tianjin 300060，China

关键词:

甲状腺微小乳头状癌; 中央区淋巴结; 转移; 危险因素

Keywords:

papillary thyroid microcarcinoma;  central compartment lymph node;  metastasis;  risk factors

分类号:

R739.91

DOI:

-

文献标志码:

A

摘要:

目的：探讨甲状腺微小乳头状癌（PTMC）患者临床病理特征与中央区淋巴结转移的关系。方法：回顾性分析413例PTMC患者的临床病理特征，应用χ2 检验和多因素Logistic回归模型分析中央区淋巴结转移的危险因素。结果：413例PTMC患者中央区淋巴结转移率为57.9%（239例）。单因素分析显示，男性、年龄＜45岁、肿瘤直径＞5 mm、肿瘤位于甲状腺下极、多灶性、包膜侵犯等均与中央区淋巴结转移有关（P＜0.05）。多因素分析显示，年龄＜45岁、包膜侵犯是PTMC中央区淋巴结转移的独立危险因素（P＜0.01）。结论：具备年龄＜45岁、包膜侵犯等特征的PTMC患者，较易发生中央区淋巴结转移，建议行预防性中央区淋巴结清扫。

Abstract:

Objective: To explore the correlation between the clinical features of papillary thyroid microcarcinoma (PTMC) and central compartment lymph node (CCLN) metastasis in PTMC. Methods: Data of 413 patients with PTMC were retrospectively analyzed. Chi-square test and multivariate logistic regression analysis were used to study the risk factors. Results:CCLN metastasis were found in 239 of 413 patients(57.9%). The univariate analysis showed that male gender, age under 45 years,tumor size bigger than 5 mm，tumor location in the lower third of the thyroid，multifocal，capsular invasion were significantly associated with CCLN metastasis（P＜0.05）. The multivariate analysis showed that the age below 45 years and capsular invasion were independently correlated with CCLN metastasis（P＜0.01）.Conclusion:A prophylactic neck dissection of the central compartment should be considered particularly in PTMC patients with age below 45 years and capsular invasion.

参考文献/References:

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相似文献/References:

[1]季艳会,谭 建,张桂芝,等.全身广泛骨转移为首发症状的甲状腺微小乳头状癌1例[J].天津医科大学学报,2015,21(04):314.

备注/Memo

备注/Memo:

文章编号 １００６－８１４７（２０18）０2-0138-04
基金项目 国家自然科学基金资助项目（81472580）
作者简介 王猛（1991-），男，硕士在读，研究方向：甲状腺颈部肿瘤；通信作者：高明，E-mail：gaoming68@aliyun.com。

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更新日期/Last Update: 2018-03-20