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[1]赵 坤,王鑫鹏,刘利维,等.前列腺体积对于PSA4～10 ng/mL患者前列腺癌诊断时穿刺方案的影响[J].天津医科大学学报,2018,24(01):40-42.
　ZHAO Kun,WANG Xin-peng,LIU Li-wei,et al.Influence of prostate volume on different prostate biopsy strategy in men with PSA 4～10 ng/mL[J].Journal of Tianjin Medical University,2018,24(01):40-42.
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前列腺体积对于PSA4～10 ng/mL患者前列腺癌诊断时穿刺方案的影响(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年01期
页码:
40-42
栏目:
临床医学
出版日期:
2018-01-20

文章信息/Info

Title:
Influence of prostate volume on different prostate biopsy strategy in men with PSA 4～10 ng/mL
文章编号:
1006-8147(2018)01-0040-03
作者:
赵 坤1; 王鑫鹏2; 刘利维1; 孙二琳1
（1.天津医科大学第二医院泌尿外科，天津市泌尿外科研究所, 天津 300211; 2.河北省沧州市中心医院泌尿外科，沧州 061000）
Author(s):
?ZHAO Kun1; WANG Xin-peng2;  LIU Li-wei1;  SUN Er-lin1
（1. Department of Urology, The Second Hospital ,Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, China；2. Department of Urology，Cangzhou Central Hospital, Cangzhou 061000，China）
关键词:
前列腺肿瘤; 前列腺体积; 系统穿刺; 饱和穿刺
Keywords:
prostate cancer;  prostate volume;  systematicbiopsy; saturation biopsy
分类号:
R737.25
DOI:
-
文献标志码:
A
摘要:
目的：探讨在前列腺特异性抗原（PSA）4～10ng/mL的前列腺癌患者中，前列腺体积对于在直肠超声引导下经直肠12针前列腺穿刺（TPBx）和经会阴前列腺饱和穿刺（TSPBx）方案选择的影响。方法：回顾性分析213例行初次前列腺穿刺的前列腺癌患者，其中TPBx穿刺组116例，TSPBx穿刺组97例，按前列腺体积分为A（30～50mL）、B（50～80mL）、C（>80mL）3组，对比两种穿刺方法的穿刺阳性率、并发症的发生率等指标。结果：在B组中TPBx和TSPBx穿刺阳性率分别为41%和56%，P=0.001；在C组中TPBx和TSPBx穿刺阳性率分别为22%和34%，P=0.008。在B、C两组中，两种穿刺方法的穿刺阳性率有统计学差异。在A组中两种穿刺方法阳性率分别为33%和20%，P=0.659，无统计学差异。两种穿刺方法的并发症发生率无统计学意义。结论：直肠超声引导下经会阴饱和24针穿刺法在前列腺体积大于50mL且PSA 4～10 ng/mL的患者中穿刺阳性率高，而且并发症发生率无明显差异。
Abstract:
Objective：To investigate the influence of prostate volume on two prostate biopsy method -transrectal prostate biopsies (TPBx) using a 12-core scheme and transeperineal saturation prostate biopsy (TSPBx) using a 24-core scheme among the prostate cancer（PCa） patients with prostatespecific antigen (PSA) level of 4～10.0 ng/mL.Methods：This retrospective study included 213 postate cancer patients who underwent initial prostate biopsy. The patients who underwent TPBx（116 men）and TSPBx (97men), were divided by the prostate volumes into 3 groups,including 30 to 50 mL group（A），50 to 80 mL group（B），and above 80 mL group（C）. The rates of prostate cancer detection and the complicationsofprostate biopsy in these groups were compared.Results：In the group B, PCa were 41% and 56% in men who underwent initial 12 cores biopsy and 24 cores biopsy, respectively(P=0.001). In the group C, PCa were 22% and 34%(P=0.008).The detection rates showed significant differences between group B and C. But the detection rates were not significantly different between group A, 33% and 20% respectively (P=0.659). The complications of the prostate biopsy in these groups showed no significant differences. Conclusion ：TRUS～guided transperineal saturation rebiopsy of the prostate using a 24-core scheme could lead to a high cancer detection rate in patients with a PSA<10 ng/mL the prostate volume >50 mL and the complications have no difference.

参考文献/References:

[1] 孙颖浩. 我国前列腺癌的研究现状[J]. 中华泌尿外科杂志, 2004, 25(2): 77

[2] Greene KL, Albertsen PC, Babaian RJ, et al. Prostate specific antigen best practice statement: 2009 update[J]. J Urol, 2013,189(1 Suppl): S2

[3] Vickers AJ, Cronin AM, Roobol MJ, et al. The relationship between prostate-specific antigen and prostate cancer risk: the Prostate Biopsy Collaborative Group[J]. Clin Cancer Res, 2010, 16(17): 4374

[4] Xu J. The Xu’s chart for prostate biopsy: a visual presentation of the added value of biomarkers to prostate-specific antigen for estimating detection rates of prostate cancer[J]. Asian J Androl, 2014, 16(4): 536

[5] 陈锐, 谢立平, 周利群,等.中国前列腺癌联盟成员医院前列腺穿刺活检现状的调查报告[J]. 中华泌尿外科杂志, 2015, 36(5): 342

[6] 中华医学会泌尿外科学分会. 前列腺穿刺中国专家共识[J]. 中华泌尿外科杂志, 2016, 37 (4):

[7] Novara G, Boscolo-Berto R, Lamon C, et al. Detection rate and factors predictive the presence of prostate cancer in patients undergoing ultrasonography-guided transperineal saturation biopsies of the prostate[J]. BJU Int, 2010, 105(9): 1242

[8] Ucer O, Yucetas U, Celen I, et al. Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey[J]. Int Braz J Urol, 2015, 41(5): 864

[9] Remzi M, Fong YK, Dobrovits M, et al. The Vienna nomogram: validation of a novel biopsy strategy defining the optimal number of cores based on patient age and total prostate volume[J]. J Urol, 2005, 174(4 Pt 1): 1256

[10] Jiang J, Colli J, El-Galley R. A simple method for estimating the optimum number of prostate biopsy cores needed to maintain high cancer detection rates while minimizing unnecessary biopsy sampling[J]. J Endourol, 2010, 24(1): 143

[11] 薛健, 梁磊, 姜文弟, 等.经会阴饱和穿刺与传统前列腺穿刺活检法诊断前列腺癌对比分析[J]. 天津医药, 2013, (9): 920

[12] 严维刚, 周毅, 周智恩, 等. 模板引导下经会阴前列腺穿刺活检10年经验总结[J]. 中华泌尿外科杂志, 2015, 36(1): 39

[13] 袁光亚, 魏强, 辛宇鹏, 等. 前列腺体积与穿刺活检阳性率和前列腺癌恶性程度的相关性[J]. 现代肿瘤医学, 2017, 25(5): 753

[14] Chen ME, Johnston DA, Tang K, et al. Detailed mapping of prostate carcinoma foci: biopsy strategy implications[J]. Cancer, 2000, 89(8): 1800

[15] Raaijmakers R, Kirkels WJ, Roobol MJ, et al. Complication rates and risk factors of 5802 transrectal ultrasound-guided sextant biopsies of the prostate within a population-based screening program[J]. Urology, 2002, 60(5): 826

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备注/Memo

备注/Memo:
基金项目 2015年度天津市留学人员科技活动启动项目择优资助计划项目基金资助

作者简介 赵坤（1991-），女，硕士在读，研究方向：泌尿外科；

通信作者：孙二琳， E-mail: 18632385631@163.com。



更新日期/Last Update: 2018-01-19