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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

23卷

期数:

2017年01期

页码:

41-43

栏目:

临床医学

出版日期:

2017-01-16

文章信息/Info

Title:

Relationship between serum levels of β2-microspheres and disease activity together with renal damage in systemic lupus erythematosus patients

文章编号:

1006-8147（2017）01-0041-03

作者:

徐 萍; 周 蕾

（天津医科大学总医院风湿免疫科，天津300052）

Author(s):

XU Ping;  ZHOU Lei

（Department of Rheumatology and Immunology ,Tianjin Medical University, General Hospital, Tianjin 300052， China）

关键词:

红斑狼疮; 系统性; β2-微球蛋白; 疾病活动度

Keywords:

lupus erythematosus; systemic; β2-microglobulin; disease activity

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分类号:

R593.24+1

DOI:

-

文献标志码:

A

摘要:

目的：探讨系统性红斑狼疮（SLE）患者血清β2-微球蛋白水平与疾病活动度及其肾脏损害的相关性及临床意义。方法：采用放射免疫法测定107例SLE 患者血清β2-微球蛋白水平，观察其与病情活动指标及肾脏损害的相关性。结果：SLE疾病活动期患者血清β2-微球蛋白水平显著高于缓解期患者[(4.76±3.00) mg/L]vs[(2.45±1.17) mg/L]，狼疮肾炎组患者血清β2-微球蛋白水平显著高于非狼疮肾炎组[(3.92±2.85) mg/L]vs[(2.63±1.25) mg/L]，分别比较差异具有统计学意义（P<0.05）；血清β2-微球蛋白水平与SLE疾病活动性指数（SLEDAI）、24 h尿蛋白呈正相关（分别为r =0.632，r =0.229，P<0.05）。结论：血清β2-微球蛋白与系统性红斑狼疮疾病活动及其肾脏损害相关。

Abstract:

Objective: To explore the clinical significance of serum levels ofβ2-microspheres and disease activity together with renal damage in systemic lupus erythematosus（SLE）patients. Methods: The levels of serumβ2-microspheres were measured by radioimmunoassay in 107 patients with SLE . Results: The levels of serumβ2-microspheres were significantly higher in active group than remissongroup[(4.76±3.00) mg/L]vs[(2.45±1.17) mg/L], the concentrations of serumβ2-microspheres in lupus nephritis patients were significantly higher than non-lupus nephritis group [(3.94±3.07) mg/L]vs[(2.86±1.47) mg/L]. The levels of serum β2-microspheres were positively correlated with?SLE disease activity index（SLEDAI）and 24 hours urine protein (respectively, r=0.632,r=0.225,P<0.05). Conclusion: Serumβ2-microglo-bulinis may associate with disease activity and renal damage in patients with SLE.

参考文献/References:

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[7]Madureira Silva M V, Moscoso-Solorzano G T, Nishida S K, et al.Serum beta 2-microglobulin/cystatin C index: a useful biomarker in lupus nephritis[J].Nephron Extra,2012,2(1):169

[8]Kim H A, Jeon J Y, Yoon J M, et al.Beta 2-microglobulin can be a disease activity marker in systemic lupus erythematosus[J].Am J Med Sci,2010,339(4):337

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备注/Memo

备注/Memo:

作者简介 徐萍（1988-），女，硕士在读，研究方向：风湿病学；通信作者：周蕾，E-mail： yizhe1234@126.com。

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更新日期/Last Update: 2017-01-16