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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年04期

页码:

354-358

栏目:

技术与方法

出版日期:

2016-07-19

文章信息/Info

Title:

Preparation and application of pH/temperature double-responsive polymer microspheres on delivery of anti-tumor drugs

文章编号:

1006-8147（2016）04-0354-05

作者:

朱 颖

(天津医科大学第二医院药学部,天津 300211)

Author(s):

ZHU Ying

(Department of Pharmacy, The Second Hospital, Tianjin Medical University, Tianjin 300211, China)

关键词:

蒸馏沉淀聚合' target="_blank" rel="external">">蒸馏沉淀聚合; pH; 温度; 可控药物释放

Keywords:

distillation-precipitation polymerization' target="_blank" rel="external">">distillation-precipitation polymerization;  pH;  temperature;  controlled drug release

分类号:

R94

DOI:

-

文献标志码:

A

摘要:

目的：制备能够在人体正常生理温度及肿瘤细胞内部酸性环境中，可实现pH/温度双重刺激响应性控制释药的抗肿瘤药物微球。方法：采用蒸馏-沉淀聚合法合成球形网状结构的载药微球，在表面沉积金纳米粒子，并用氯金酸还原法，将沉积在微球上的氯金酸中Au^3＋还原为Au⁰，并通过细胞实验检测该微球的毒性。结果：成功合成聚合物微球P(MAA-MBA)-EDA-FA-AuNP，发现其pH/温度的可控释药特性，以及在高浓度下仍然保持较低毒性。结论：初步评价了P(MAA-MBA)-EDA-FA-AuNP聚合物微球作为抗肿瘤药物输送体系的潜力和优势。

Abstract:

?Objective: To prepare pH/temperature dual stimuli responsive polymer microspheres on controlled release of anti-tumor drugs at normal human body temperature and in acid environment for tumor cells. Methods: The drug carrier microspheres with spherical mesh structure were synthesized via distillation-precipitation polymerization. Gold nanoparticles were deposited on the surface of obtained microspheres, and then the Au³⁺ was reduced to Au⁰ by chloroauric acid reduction method. Finally, the toxicity of microspheres was tested using cell experiments. Results: The polymer microspheres P(MAA-MBA)-EDA-FA-AuNP were successfully synthesized, which showed pH/temperature controlled drug release characteristic and low toxicity even at high concentration. Conclusion: The advantages of polymer microspheres P(MAA-MBA)-EDA-FA-AuNP may function as a potential anti-tumor drug delivery system.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 朱颖（1987-），女，药师，硕士在读，研究方向：药剂学;E-mail:576195126@qq.com。

常用功能

更新日期/Last Update: 2016-07-13