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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年06期

页码:

516-519

栏目:

临床医学

出版日期:

2016-11-20

文章信息/Info

Title:

Exploring the risk factors of recurrence in 214 patients with non-muscle invasive bladder cancer by retrospectively analysis

文章编号:

1006-8147（2016）06-0516-4

作者:

吴雨征; 杨 同; 安泽生; 薄志强; 张洪团; 张昌文; 徐 勇

(天津医科大学第二医院泌尿外科;天津市泌尿外科研究所,天津 300211)

Author(s):

WU Yu-zheng;  YANG Tong;  AN Ze-sheng;  BO Zhi-qiang;  ZhANG Hong-tuan;  ZhANG Chang-wen;  XU Yong

(Department of Urology, The Second Hospital ,Tianjin Medical University,Tianjin Institute of Urology,Tianjin 300211,China)

关键词:

膀胱肿瘤; 复发; 风险因素

Keywords:

urinary bladder neoplasms;  recurrence;  risk factors

分类号:

737.14

DOI:

-

文献标志码:

A

摘要:

目的：分析影响非肌层浸润性膀胱癌复发的风险因素及其临床意义。方法：回顾分析214例非肌层浸润性膀胱癌患者的全部临床资料，对性别，年龄，体质量指数，是否合并高血压、糖尿病，肿瘤数量、大小（多发肿瘤以最大肿瘤直径定义）、分期、组织学分级，术后是否即刻灌注治疗，静脉化疗等因素进行生存分析，初次复发或进展为终点事件，运用Log-Rank检验，Kaplan-Meier法单因素分析比较各因素无病生存率差异，Cox比例风险回归模型多因素分析复发的独立风险因素。结果：214例非肌层浸润性膀胱癌患者平均就诊年龄68.5岁，男：女=1.4：1，随访时间8～48个月，复发63例（总复发率29.3%）。单因素分析发现，肿瘤数目，肿瘤大小，肿瘤分级，肿瘤分期，是否行即刻膀胱灌注治疗与复发相关有统计学意义（均P＜0.05）。多因素分析显示，肿瘤数目，肿瘤大小，肿瘤分级，肿瘤分期，是否行即刻膀胱灌注治疗是非肌层浸润性膀胱癌复发的独立预测因子。结论：肿瘤数目，肿瘤大小，肿瘤分级，肿瘤分期是非肌层浸润性膀胱癌复发的独立风险因素。膀胱即刻灌注是非肌层浸润性膀胱癌的保护因素。

Abstract:

Objective ：To explore the main influencing factors and clinical significance of the recurrence of non-muscle invasive bladder cancer (NMIBC). Methods: Two hundred and fourteen patients with NMIBC were retrospectively reviewed in single center. Gender, age，BMI ,hypert-ension,diabetes,tumor size, tumor number, tumor grade, tumor stage, immediately intravesical instillation and intravesical chemotherapy were predicted to be the risk factors.Survival analysis was carried out by employing Kaplan-Meier and Cox proportional hazard model. Results: Finally 214 patients with NMIBC were studied, with mean age of 68.5 years at presentation, and male to female ratio was 1.4∶1. Based on 8-48 months of following up, 63(29.3%) of 214 cases had recurrence .Univariate analysis indicated that number, size, grade and stage of tumor and immediate intravesical instillation were significantly associated with the recurrence of NMIBC (all P<0.05). Number, size, grade and stage of tumor and immediate intravesical instillation were independent risk factors for recurrence of NMIBC. Conclusion: number, size, grade and stage of tumor are the independent risk factors for recurrence of NMIBC. Immediate intravesical instillation is protective for recurrence of NMIBC.

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备注/Memo

备注/Memo:

作者简介 吴雨征（1991-），男，硕士在读，研究方向：泌尿外科；

通信作者：徐勇，E-mail：xuyong8816@sina.com。

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更新日期/Last Update: 2016-11-25