|本期目录/Table of Contents|

[1]吴 云,朱 东,余亚杰,等.颈动脉狭窄血液动力学研究[J].天津医科大学学报,2016,22(04):295-299.
　WU Yun,ZHU Dong,Yu Ya-jie,et al.Study on the?hemodynamics?of? carotid artery stenosis[J].Journal of Tianjin Medical University,2016,22(04):295-299.
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颈动脉狭窄血液动力学研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年04期
页码:
295-299
栏目:
基础医学
出版日期:
2016-07-19

文章信息/Info

Title:
Study on the?hemodynamics?of? carotid artery stenosis
文章编号:
1006-8147（2016）04-0295-05
作者:
吴 云1 ; 朱 东2 ; 余亚杰2 ; 许松林2
（1． 天津市南开区王顶堤医院内科， 天津 300190；2. 天津大学化工学院制药工程系，系统生物工程教育部重点实验室，天津300072）
Author(s):
WU Yun1;  ZHU Dong2; ?Yu Ya-jie2; Xu Song-lin2
（1.Department of Medicine, Wangdingdi Hospital of Tianjin Nankai District, Tianjin 300190，China；2.Department of Pharmaceutical Engineering，School of Chemical Engineering and Technology，Tianjin University，Tianjin 300072，China)
关键词:
脂肪颗粒; 颈动脉; 栓塞; 狭窄
Keywords:
fat particles; carotid artery; embolism; stenosis
分类号:
R543.4
DOI:
-
文献标志码:
A
摘要:
目的：研究狭窄程度不同的颈动脉区域中脂肪颗粒运动及其对血管和血液动力学影响。方法：基于血管造影技术，采用CFD软件对2D颈动脉分叉血管模型进行模拟和分析。结果：脂肪颗粒在颈动脉中的运动不仅与狭窄程度有关，也与脂肪颗粒个数有关。结论：颈动脉狭窄程度会影响脂肪颗粒的运动，其狭窄区域后方也易产生回流和形成血栓。同时脂肪颗粒的运动会加重狭窄程度，增大壁面剪切力并导致栓塞形成，促进病变进一步发展。
Abstract:
Objective: To study the movement of fat particles in different degrees of carotid artery stenosis and its influence on blood vessel and hemodynamics. Methods: Based on the angiographic technique, CFD was used to simulate and analyze 2D carotid bifurcation vessel model. Results: The movement of fat particles in carotid artery was related to the degree of stenosis and the amount of fat particles. In addition, its presence would increase the wall shear force. Conclusion: The degree of carotid stenosis can affect the movement of fat particles, and the region behind the stenosis could easily generate backflow and thrombosis; meanwhile, the movement of fat particles can increase the degree of stenosis and the wall shear force, and might lead to the formation of embolism which would promote the further development of the disease.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目(21176170).

作者简介 吴云(1970-),女,主治医师,研究方向：内科理论与临床；通信作者：许松林，E-mail: slxu@tju.edu.cn。

更新日期/Last Update: 2016-07-12