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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年04期

页码:

291-294

栏目:

基础医学

出版日期:

2016-07-19

文章信息/Info

Title:

Research on the influence of bone on high intensity focused ultrasound focusing

文章编号:

1006-8147（2016）04-0291-04

作者:

曾苗苗;  钱宇晗;  常诗卉;  菅喜岐

(天津医科大学生物医学工程与技术学院,天津 300070)

Author(s):

ZENG Miao-miao;  QIAN Yu-han;  CHANG Shi-hui;  JIAN Xi-qi

(School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070,China)

关键词:

高强度聚焦超声; 羊肩胛骨; 颅骨; 仿组织体模

Keywords:

HIFU;  scapula of sheep;  skull;  tissue-mimicking phantom

分类号:

R454.3

DOI:

-

文献标志码:

A

摘要:

目的：测定HIFU经过羊肩胛或人体离体颅骨形成的声压场及焦域，研究骨骼对HIFU聚焦的影响。方法：单阵元换能器发射超声波，经羊肩胛骨或者人体颅骨聚焦，通过水听器测量形成声场，通过含蛋清仿组织体模测量不同辐照条件形成的焦域大小。结果：羊肩胛骨及人体颅骨均可对声压造成极大的衰减；经骨骼后在激励功率达80 W时焦点声压与纯水中激励功率2 W相近，羊肩胛骨激励条件250 W、辐照时间3 min下可使仿体组织产生焦域；颅骨则在最大强度300 W、5 min下无焦域产生。结论：HIFU经骨骼聚焦时，增大输入功率或辐照时间，焦域体积增大。在单阵元换能器辐照环境下，经骨骼聚焦困难，焦点声压较低，形成焦域较小或无焦域形成，增大时间骨骼易产生热损伤。

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Abstract:

Objective: To measure the sound pressure field and focal regions of HIFU to determine the effect of bone on ultrasound focusing. Methods: A single-element transducer was used for emitting ultrasound, the sound pressure was measured by hydrophone，and the focal regions were measured by egg-white tissue-mimicking phantom after sound wave spread through scapula of sheep or human skull. Results: Scapula of sheep and human skull both resulted in severe attenuation of sound pressure; similar sound pressure was observed in hydrophone when driving power was set to 2 W in degassed water and 80 W after scapula of sheep was added, and a focal region was generated in egg-white tissue-mimicking phantom with 250 W, 3 min; at maximum intensity 300 at 5 min， no focal region was observed when sound wave went through human skull. Conclusion: The focal regions increase with driving power or irradiation time. The sound pressure is low and focal regions are small or absent in the condition of the single-element. Increasing the irradiation time may cause thermal damage in bones.

参考文献/References:

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[2]王韶林，肖雪刚，陈晓瑞，等.高强度聚焦超声焦域的实验研究[J].中国超声医学杂志,2012,28(5):385
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相似文献/References:

[1]薛凡凡,常诗卉,菅喜岐.血管对高强度聚焦超声焦域影响的体模实验研究[J].天津医科大学学报,2014,20(04):275.
　XUE Fan-fan,CHANG Shi-hui,JIAN Xi-qi.Experimental study on the effect of blood vessel on high intensity focused ultrasound focal region in phantom[J].Journal of Tianjin Medical University,2014,20(04):275.
[2]钱宇晗,张艳秋,霍 然,等.HIFU经颅脑肿瘤治疗参数筛选的数值仿真研究001[J].天津医科大学学报,2018,24(05):369.
　QIAN Yu-han,ZHANG Yan-qiu,HUO Ran,et al.Study on parameters screening for the numerical simulation of transcranial tumor treatment with high intensity focused ultrasound[J].Journal of Tianjin Medical University,2018,24(04):369.

备注/Memo

备注/Memo:

基金项目 国家自然科学基金资助项目（81272495）

作者简介 曾苗苗（1990-），女，硕士在读，研究方向：超声医学；通信作者：菅喜岐，E-mail:jianxiqi@tmu.edu.cn。

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更新日期/Last Update: 2016-07-12