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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年06期

页码:

545-封3

栏目:

综述

出版日期:

2015-11-20

文章信息/Info

Title:

-

文章编号:

1006-8147（2015）06-0545-04

作者:

耿婉如¹ ; 杨桂荣²综述 ; 孙洪涛³ 审校

（内蒙古民族大学附属医院1.呼吸科；2.检验科；3.心血管科，通辽 028000）

Author(s):

-

关键词:

YAP; Hippo通路; 胚胎发育; 组织再生; 癌症

Keywords:

-

分类号:

R730.2

DOI:

-

文献标志码:

A

摘要:

-

Abstract:

-

参考文献/References:

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[2]Zhao B L, Guan K L. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)[J].Genes Dev, 2010, 24(1):72

[3]Dupont S, Morsut L, Aragona M, et al. Role of YAP/TAZ in mechanotransduction[J].Nature,2011,474(7350):179

[4]Aragona M, Panciera T, Manfrin A A, et al. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by Actin-Processing factors[J].Cell,2013,154(5):1047

[5]Oka T, Remue E, Meerschaert K, et al. Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling[J].Biochem J,2010,432(3):461

[6]Schlegelmilch K, Mohseni M, Kirak O, et al. Yap1 Acts downstream of alpha-Catenin to control epidermal proliferation[J]. Cell, 2011, 144 (5):782

[7]Michaloglou C, Lehmann W, Martin T A, et al. The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity[J].PLoS One, 2013, 8(4):e61916

[8]Poon C L, Harvey K F. Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth[J].Curr Biol, 2012, 22(17):1587

[9]Jiao S, Wang H Z, Shi Z B, et al. A peptide mimicking VGLL4 function Acts as a YAP antagonist therapy against gastric Cancer[J].Cancer Cell,2014,25(2):166

[10]Zhao B, Ye X, Yu J D, et al. TEAD mediates YAP-dependent gene induction and growth control[J].Genes Dev,2008,22(14):1962

[11]Zhu, Y, Li D, et al. Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs[Z].2014

[12]Morin-Kensicki M, M E, Boone B N, et al. Defects in yolk sac vasculogenesis,chorioallantoic fusion,and embryonic axis elongation in mice with targeted disruption of Yap65[J].Mol Cell Biol, 2006,26(1):77

[13]Lian I, Kim J, Okazawa H, et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation[J].Genes Dev,2010,24(11):1106

[14]Li Y A, Yun K. Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt,SHH,and hippo pathway effectors by Notch1[J].Stem Cells,2012,30(4):741

[15]Dong J X, Feldmann G, Huang J B, et al. Elucidation of a Universal size-control mechanism in Drosophila and mammals[J]. Cell, 2007, 130(6):1120

[16]Watt K I, Judson R, Medlow P, et al. Yap is a novel regulator of C2C12 myogenesis[J].Biochem Biophys Res Commun,2010,393(4):619

[17]Mahoney J E, Cardoso W V. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors[J]. Dev Cell,2014,30(2):137

[18]Lin, Z, Gise A V, et al. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model[J].Circ Res,2014,115(3):354

[19]Lee M J, Jung H S. YAP and TAZ regulate skin wound healing[J].J Invest Dermatol,2014,134(2):518

[20]Steinhardt A A, Gayyed M F, Klein A P, et al. Expression of yes-associated protein in common solid tumors[J].Hum Pathol, 2008, 39(11):1582

[21]Xie, Q, Chen J, et al. YAP/TEAD-mediated transcription controls cellular senescence[J].Cancer Res,2013,73(12):3615

[22]Wang Y D, Qiu X. Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung Cancer[J].Cancer Sci,2010,101(5):1279

[23]Xia Y L, Fan H Y. YAP/TEAD Co-Activator regulated pluripotency and chemoresistance in ovarian Cancer initiated cells[J].PLoS One, 2014, 9(11):e109575

[24]Yuan M, Tomlinson V, Lara R, et al. Yes-associated protein (YAP) functions as a tumor suppressor in breast[J].Cell Death Differ, 2008,15(11):1752

[25]Wang Q, Xu Z L, An Q, et al. TAZ promotes epithelial to mesenchymal transition via the upregulation of connective tissue growth factor expression in neuroblastoma cells[J].Mol Med Rep,2015,11(2):982

[26]Anand R, Maksimoska J, Pagano N, et al. Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor[J].J Med Chem,2009,52(6):1602

[27]Liu-Chittenden L, Y, Huang B, et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP[J].Genes Dev,2012,26(12):1300

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