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[1]许娇娇,靳德军,王 佳,等.中国南海海绵Haliclona sp.中化学成分的研究[J].天津医科大学学报,2015,21(05):385-387.
　XU Jiao-jiao,JIN De-jun,WANG Jia,et al.Studies on chemical constituents from the South China Sea sponge Haliclona sp.[J].Journal of Tianjin Medical University,2015,21(05):385-387.
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中国南海海绵Haliclona sp.中化学成分的研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年05期
页码:
385-387
栏目:
基础医学
出版日期:
2015-09-20

文章信息/Info

Title:
Studies on chemical constituents from the South China Sea sponge Haliclona sp.
文章编号:
1006-8147（2015）05-0385-03
作者:
许娇娇1; 靳德军2; 王 佳1; 祁菁1; 赵 川3; 乔 卫1; 段宏泉1;  3; 唐生安1
(1.天津医科大学药学院,天津市临床药物关键技术重点实验室,天津300070; 2. 海南医学院药学院,海口,571199;3. 天津医科大学基础医学研究中心,天津300070)
Author(s):
XU Jiao-jiao1;  JIN De-jun2;  WANG Jia1;  QI Jing 1; ZHAO Chuan3;  QIAO Wei1;  DUAN Hong-quan 1;  3;  TANG Sheng-an1
(1. School of Pharmacy, Tianjin Medical University, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin 300070, China; 2. School of Pharmaceutical Science, Hainan Medical University, Haikou 571199, China; 3. Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China)
关键词:
南海海绵; Haliclona sp.; 化学成分
Keywords:
marine sponge;  Haliclona sp.;  chemical constitunents
分类号:
R9
DOI:
-
文献标志码:
A
摘要:
目的：对采自中国广西涠洲岛海域海绵Haliclona sp.的化学成分进行分离和结构鉴定。方法：采用硅胶柱色谱、制备薄层色谱、凝胶柱色谱、半制备HPLC、重结晶等方法分离纯化,通过波谱方法分析,并对照文献来鉴定化合物的结构。结果:从海绵Haliclona sp.中分离的5个化合物,依次鉴定为孕甾烯醇酮 (1), 24-亚甲基胆甾醇 (2), 胆甾醇 (3), 苯丙酸 (4), 邻二苯甲酸丁酯 (5)。结论: 4, 5为首次从该属海绵中分离得到的化合物。
Abstract:
Objective: To study the chemical constituents from the South China Sea sponge Haliclona sp..Methods: The isolation and purification of the compounds were performed by column chromatography techniques with silica gel, PTLC, Toyopearl HW-40 and semi-preparative HPLC. Their structures were determined mainly by spectral data analysis and comparison with literatures. Results: Five compounds had been isolated and their structures were identified as pregnenolone (1), 24-methylenecholesterol (2), cholesterol (3), phenylpropionic acid (4), dibutylphthalat (5). Conclusion: Compounds 4, 5 have been isolated for the first time from the genus Haliclona.

参考文献/References:

[1] Fusetani N, Yasumuro K, Matsunaga S. Haliclamines A and B, cytotoxic macrocyclic alkaloids from a sponge of the genus Haliclona[J]. Tetrahedron Lett , 1989, 30(49): 6891
[2] Randazzo A, Bifulco G, Giannini C, et al. Halipeptins A and B: Two novel potent Anti-inflammatory cyclic depsipeptides from the vanuatu marine sponge Haliclona species[J]. J Am Chem Soc, 2001, 123(44): 10870
[3] 刘永宏，，[J].热带海洋学报, 2008, 27(1):70
[4] 陈建涛,杨帆,张红军,等. 海绵Haliclona oculata化学成分的研究[J]. 药学实践杂志，2010, 28(1):52
[5] VOlk C A, Kock M. Viscosaline: new 3-alkyl pyridinium alkaloid from the arctic sponge Haliclona viscosa[J]. Org Biomol Chem, 2004, 2(13): 1827
[6] BokeschH R, Stulla A C, Pannell L K, et al. A new pentacyclic sulfated hydroquinone from the marine sponge Haliclona sp.[J ]. Tetrahedron Lett, 2002, 43(16):3079
[7] 吴旭东,梅文莉,邵长伦，等. 中国南海蜂海绵Haliclona cymaeformis的化学成分研究[J ].中国海洋药物杂志, 2011, 30(5):12
[8] 常新亮,马云保,张雪梅,等. 川芎化学成分研究 [J]. 中国中药杂志,2007, 32(15):1533
[9] 匡云艳,蓝文建,苏镜娱,等. 圆形短指软珊瑚化学成分的研究[J]. 热带海洋学报,2002, 21(3):95
[10] 吴旭东.南海海绵Haliclona cymaeformis和Topsentia sp.化学成分及生物活性研究[D]. 中国海洋大学,2011, 33
[11] 葛洁虹，高程海,王萍,等. 南海二叉黑角珊瑚化学成分研究[J]. 中药材,2010, 33(9):1403
[12] 吴霞,于志斌,叶蕴华,等. 荜茇化学成分的研究[J]. 中草药,2008, 39(2): 178
[13] 李文林,毛世龙,易杨华,等. 丰头皮海绵化学成分研究[J]. 中国海洋药物, 2000, 3:1

相似文献/References:

[1]许娇娇,等. 中国南海海绵Axinella sp.中化学成分的研究[J].天津医科大学学报,2015,21(03):217.
　XU Jiao-jiao,GU Qiong,et al.Studies on chemical constitunents in the South China Sea marine sponge Axinella sp.[J].Journal of Tianjin Medical University,2015,21(05):217.

备注/Memo

备注/Memo:

基金项目 国家自然科学基金资助项目(81102371), 天津市自然科学基金资助项目(10JCYBJC15000)

作者简介 许娇娇(1989-),女,硕士在读,研究方向：天然产物有效分离、分析研究；通信作者：唐生安，E-mail: tangshengan@tijmu.edu.cn。





更新日期/Last Update: 2015-09-21