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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年02期

页码:

101-104

栏目:

基础医学

出版日期:

2015-03-20

文章信息/Info

Title:

Change of interleukin-18 in OLETF rats with insulin resistance and effects of telmisartan

文章编号:

1006-8147（2015）02-0101-04

作者:

王伟占¹; 4; 孙立亭¹; 赵志强²;  田凤石³

(1.天津医科大学研究生院,天津 300070;2.天津医科大学第二医院心内科, 天津 300211;3.天津市第四中心医院心内科,天津 300140;天津医科大学第四中心临床学院心内科，天津 300140)

Author(s):

WANG Wei-zhan¹; 4;  SUN Li-ting¹ ;  ZHAO Zhi-qiang² ;  TIAN Feng-shi³

(1.Graduate  School，Tianjin Medical University, Tianjin 300070 China; 2. Department of Cardiology， The Second Hospital， Tianjin Medical University ,Tianjin 300211 China,；3. Department of Cardiology ，The Fourth Center Hospital of Tianjin , Tianjin 300140 China ；4.Department of Cardiology，The Fourth Center Clinical College,Tianjin Medical University ,Tianjin  300140 China )

关键词:

胰岛素抵抗; 替米沙坦; OLETF大鼠; 白介素-18

Keywords:

insulin resistance;  telmisartan;  OLETF rats;  IL-18

分类号:

R589

DOI:

-

文献标志码:

A

摘要:

目的：测定胰岛素抵抗（IR）OLETF大鼠血清白介素-18（IL-18）的表达水平，研究血管紧张素Ⅱ 1型受体拮抗剂 (AT1R) 替米沙坦对IL-18水平的影响及对IR的干预作用，探讨其改善IR的可能机制。方法：OLETF大鼠24只，高脂喂养20周诱导建立IR模型，将成功造模的24只IR大鼠随机分为2组，模型（M）组12只继续给予高脂饲料，替米沙坦（T）组12只给予替米沙坦（5 mg/kg﹒d）加高脂饲料，LETO大鼠12只为对照(NC)组，给予标准饲料。干预20周后测定两组大鼠的体质量（W）、血清胰岛素（FINS）、空腹血糖（FBG）、甘油三酯(TG)、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）及IL-18水平，并计算胰岛素抵抗指数（HOMA-IR）、胰岛素敏感指数（ISI）。 结果：M组大鼠与NC组大鼠相比，W、FBG、TG、LDL-C及IL-18水平明显增高（P<0.05或P <0.01） ；T组与M组相比，FBG、TG、LDL-C、IL-18水平明显降低（P<0.05或P <0.01） 。多元线性回归分析提示IL-18是HOMA-IR的独立影响因素。 结论：IL-18可能通过促进炎症参与了IR，而替米沙坦可能通过调节糖脂代谢、抑制前炎性因子IL-18的表达改善IR。

Abstract:

Objective: To investigate change of interleukin-18 (IL-18) in OLETF rats with insulin resistance, and to study the effect of angiotensin II type 1 receptor antagonists (AT1R) telmisartan on insulin resistance and the expression of IL-18, and the possible mechanisms of telmisartan improving IR. Methods: Twenty-four OLETF rats were fed with high-fat diet for 20 weeks to establish the insulin resistance model. Twenty-four OLETF rats with insulin resistance were randomly assigned into two groups: the model group (group M), in which the rats were fed with high-fat diet; the telmisartan group (group T), in which the rats were fed with high-fat diet and telmisartan（5 mg/kg﹒d）. Twelve LETO rats fed with normal diet served as normal control group (group NC). After 20 weeks of drug intervention, the weight（W），plasma levels of fasting insulin (FINS), fasting blood glucose(FBG), triglycerides(TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and interleukin-18 (IL-18) were detected in two groups. And HOMA-IR and ISI were measured. Results: Compared with group NC, the W，FBG，TG，LDL-C and IL-18 were significantly increased in group M（P <0.05 or P <0.01）; compared with group M, the FBG，TG，LDL-C and IL-18 were significantly decreased in group T（P <0.05 or P <0.01） . The multiple linear regression analysis showed that the serum IL-18 was an independent determinant of HOMA-IR. Conclusion: The IL-18 is an independent factor for IR, and telmisartan can improve insulin resistance by regulating blood glucose and serum lipid as well as inhibiting the expression of IL-18 .

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备注/Memo

备注/Memo:

作者简介 王伟占（1987-），女，硕士在读，研究方向：心血管内科；

通信作者：田凤石，E-mail：fengshitian080101@.126.com。

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更新日期/Last Update: 2015-03-24