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[1]赵 欣.,于泳浩.重比重罗哌卡因用于剖宫产手术的ED50和ED95[J].天津医科大学学报,2014,20(04):300-302.
　ZHAO Xin .,YU Yong-hao.ED50 and ED95 of intrathecal hyperbaric ropivacaine in patients under cesarean delivery[J].Journal of Tianjin Medical University,2014,20(04):300-302.
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重比重罗哌卡因用于剖宫产手术的ED50和ED95(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年04期
页码:
300-302
栏目:
临床医学
出版日期:
2014-07-08

文章信息/Info

Title:
ED50 and ED95 of intrathecal hyperbaric ropivacaine in patients under cesarean delivery
文章编号:
1006-8147（2014）04-0300-03
作者:
赵 欣1.2;  于泳浩3
(1.天津医科大学研究生院,天津300070；2.天津中心妇产科医院麻醉科，天津300046； 3.天津医科大学总医院麻醉科，天津300052)
Author(s):
ZHAO Xin 1.2;  YU Yong-hao 3
（1. Gradulate School , Tianjin Medical University , Tianjin 300070,China; 2. Department of Anesthesiology, Tianjin Center Gynaecological and Obstetrical Hospital, Tianjin 300046,China; 3. Department of Anesthesiology, General Hospital, Tianjin Medical University ,Tianjin 300052,China）
关键词:
罗哌卡因; 剖宫产; 有效剂量
Keywords:
ropivacaine;  cesarean;  effective dose
分类号:
R614
DOI:
-
文献标志码:
A
摘要:
目的： 确定普通及肥胖产妇行剖宫产手术时蛛网膜下腔罗哌卡因的有效剂量（ED50/ED95），并进行比较。 方法：选择行剖宫产手术普通产妇[（BMI）<35]及肥胖产妇（BMI≥35）各 42例, 分别随机分为7组，采用重比重罗哌卡因行蛛网膜下腔阻滞，剂量分别为6、7、8、9、10、11、12 mg（n=7），当阻滞平面到达或超过T6，整个手术过程不需再硬膜外追加给药，认为阻滞完善。用对数回归模型计算各组罗哌卡因ED50和ED95的值。 结果：普通产妇罗哌卡因蛛网膜下腔阻滞的ED50和ED95（95%可信区间）分别为10.0（9.1~10.5）mg和13.4（11.5~15.3）mg。肥胖患者ED50和ED95（95%可信区间）分别为10.8（9.6~12.0）mg和16.0（11.0~21.0）mg, 组间无统计学差异。术中其他状况（高血压、应用升压药、恶心呕吐）也无统计学意义。 结论：重比重罗哌卡因用于肥胖和非肥胖产妇蛛网膜下腔阻滞在行剖宫产手术时，有效剂量没有统计学差异。
Abstract:
Objective： To determine the effective dose (ED50/ED95) of intrathecal hyperbaric ropivacaine for cesarean delivery in non-obese patients and morbidly obese patients. Methods： Forty-two parturients ( BMI<35 for non-obese patients) and ( BMI ≥ 35 for morbidly obese patients) undergoing elective cesarean delivery were randomly assigned to receive intrathecal hyperbaric ropivacaine in doses of 6,7,8,9,10,11, 12mg (n=6 ). Success was defined as block height to pinprick equal to or more than T6 and no requirement for epidural supplementation throughout surgery. The ED50 and ED95 values were determined using a logistic regression model. Results： ED50 and ED95(with 95% confidence intervals) for success (operation) were 10.0（9.1~10.5）mg and 13.4（11.5~15.3）mg, respectively, in non-obese population ,and were 10.8(9.6~12.0) mg and 16.0(11.0~21.0)mg, in obese population. No difference was found between two groups. And the same results were found with regard to secondary outcomes (hypotension, vasopressor use, nausea, and vomiting). Conclusion: Obese and non-obese patients under cesarean delivery do not appear to respond differently to effective doses of intrathecal ropivacaine.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介  赵欣（1969-），女，副主任医师，硕士在读，研究方向：麻醉学；通信作者：于泳浩。E-mail：yuyonghao@126.com。
更新日期/Last Update: 2014-06-06