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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

19卷

期数:

2013年06期

页码:

478-483

栏目:

临床医学

出版日期:

2013-11-20

文章信息/Info

Title:

Investigation on pathogenesis of erythropoietin hyporesponsiveness in patients with continuous ambulatory peritoneal dialysis

作者:

孙 鹏; 夏 天

天津医科大学第二医院肾内科，天津300211

Author(s):

SUN Peng; XIA Tian

Department of Nephrology,The Second Hospital，Tianjin Medical University,Tianjin 300211，China

关键词:

腹膜透析; 超敏C反应蛋白; 白蛋白; 促红细胞生成素; 铁蛋白

Keywords:

peritoneal dialysis; high sensitive C-reactive protein; albumin; erythropoietin; ferroprotein

分类号:

R692

DOI:

-

文献标志码:

A

摘要:

目的：探讨腹膜透析患者促红细胞生成素（EPO）低反应性的发生机制。方法：选取持续非卧床腹膜透析（CAPD）患者76例，测定其超敏C-反应蛋白（Hs-CRP）、血红蛋白（Hb）、红细胞压积（Hct）、铁蛋白（FER）、甲状旁腺素（iPTH）、血肌酐（Scr）、白蛋白（Alb）等各项临床指标。根据EPO反应性不同分为两组：EPO低反应组及EPO反应良好组。另外选择健康对照组40例。比较分析各组指标的差异。结果：EPO低反应组患者超敏C反应蛋白、铁蛋白水平明显高于反应正常组，白蛋白水平低于正常组。结论：慢性炎症及营养不良是导致腹膜透析患者EPO低反应性的重要原因。

Abstract:

Objective: To investigate the pathogenesis of erythropoietin(EPO) hyporesponsiveness in patients with continuous ambulatory peritoneal dialysis． Methods: Seventy six patients with continuous ambulatory peritoneal dialysis were selected， and the serum levels of high sensitive C-reactive protein (Hs-CRP), hemoglobin(Hb), hematokrit(Hct), ferroprotein(FER), iPTH, serum creatinine(Scr) and albumin(Alb) were measured. The patients were divided into two groups according to the responsiveness to EPO: good response and poor response. Meanwhile， forty healthy subjects served as control group. The differences among the groups were compared and analyzed. Results: The levels of high sensitive C-reactive protein, and ferroprotein in poor response group were obviously higher than the good response group. Meanwhile, the levels of albumin were lower than good response. Conclusion: Chronic inflammation and malnutrition play an important role in pathogenesis of hyporesponsivcness to EPO in patiets with continuous ambulatory peritoneal dialysis.

参考文献/References:

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[7］ Kim J K，Park B S，Park M J，et al． The predictiveParameters of erythropoietin hyporesponsiveness in patients on continuous ambulatory peritoneal dialysis[J]． Korean J Intern Med，2001，16(2)：110
[8］ 叶云洁，倪兆慧，钱家麒,等. 终末期肾病微炎症状态和动脉粥样硬化的关系[J]. 中华肾脏病杂志，2004，20(3)：173
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[1１］ Moshyedi A K, Josephs M D, Abdalla E K, et al. Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha[J]. Infect Immun, 1998, 66(4): 1800

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备注/Memo

备注/Memo:

作者简介 孙鹏（1987-），男，硕士在读，研究方向：肾脏病；通信作者：夏天，E-mail:xiatian01@medmail.com.cn。

常用功能

更新日期/Last Update: 2013-12-20