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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

19卷

期数:

2013年06期

页码:

468-470

栏目:

临床医学

出版日期:

2013-11-20

文章信息/Info

Title:

Predictive value of ambulatory arterial stiffness index for coronary heart disease in primary hypertensive patients

作者:

陈 云; 袁如玉; 阎哲慧; 李广平

天津医科大学第二医院心脏科，天津 300211

Author(s):

CHEN Yun; YUAN Ru-yu; YAN Zhe-hui;  LI Guang-ping

Department of Cardiology, The Second Hospital,Tianjin Medical University,Tianjin 300211, China

关键词:

高血压; 动态动脉硬化指数; 冠心病; Gensini积分

Keywords:

hypertention;  ambulatory arterial stiffness index;  coronary heart disease;  coronary stenosis score

分类号:

R544.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨原发性高血压患者应用动态动脉硬化指数（AASI）对冠心病的预测价值。方法：入选高血压患者226例, 所有患者均行24 h动态血压（ABPM）监测并计算AASI，行冠状动脉造影检查并依据造影结果进行Gensini评分（CSS），按照评分结果分为3组：0～1分的非冠心病组（70例），2～31分的轻、中度冠脉病变组（104例），≥32分的重度冠脉病变组（52例），采用单因素方差分析及Logistic回归分析与冠脉相关的危险因素。结果：单因素分析结果显示，3组间AASI差异显著（P<0.05），组间两两比较在ＡＡＳＩ水平上仍有统计学意义（Ｐ＜０．０５），即冠脉狭窄越严重，ＡＡＳＩ越高；Ｌｏｇｉｓｔｉｃ回归分析显示，调整年龄、２４ ｈ心率、血压杓型等影响因素后，ＡＡＳＩ与冠心病的发生仍具有较好的相关性（ＯＲ＝３．４７１，Ｐ＜０．０１）。结论：ＡＡＳＩ对高血压患者出现冠脉病变及其严重程度有较好的预测价值。

Abstract:

Objective: To investigate the role of ambulatory arterial stiffness index (AASI) to predict coronary heart disease(CHD) in hypertensive patients. Methods: A total of 226 hypertensive inpatients were included in the study. AASI was obtained from individual 24-hour blood pressure readings. The subjects were divided into three groups according to coronary stenosis score(CSS) after coronary angiography to evaluate the severity of coronary artery lesions : non CHD（0～1 score）group, mild lesion（2～31 scores）group and severe lesion（≥32 scores）group. The differences between the three groups were compared. The correlation between AASI and CHD were analyzed with Logistic regression. Results: AASI was significantly higher in patients with soft and severe artery lesions of CHD than in non CHD(P<0.05) .With the CSS increasing, the patients had higher AASI . Correlation between AASI and CHD was significant by Logistic regression after adjusting for confounding factors(P<0.05). Conclusion: AASI is closely related to the CHD and the severity of coronary artery stenosis.

参考文献/References:

[1] Gomez-Marcos M A, Recio-Rodriguez J I, Patino-Alonso M C, et al. Ambulatory arterial stiffness indices and target organ damage in hypertention[J]. BMC Cardiovascular disorders, 2012,12(1):1
[2］ Krause T, Lovibond K, Caulfield M, et al. Management of hypertension: summary of NICE guidance[J]. BMJ, 2011,343:d4891
[3］ Gensini G G. A more meaningful scoring system for determining the severity of coronary heart disease[J]. Am J Cardiol, 1983, 51(3): 606
[4］ Dolan E, Thijs L, Li Y, et al. Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study[J]. Hypertension, 2006,47(3):365
[5］ García-García A, Gómez-Marcos M A, Recio-Rodriguez J I, et al. Relationship between ambulatory arterial stiffness index and subclinical target organ damage in hypertensive patients[J]. Hypertens Res, 2011, 34(2): 180
[6］ Kollias A, Stergiou G S, Dolan E, et al. Ambulatory arterial stiffness index: A systematic review and meta analysis[J]. Atherosclerosis, 2012,224(2):291
[7］ Dechering D G, van der Steen M S, Adiyaman A, et al. Reproducibility of the ambulatory arterial stiffness index in hypertensive patients[J]. J Hypertens, 2008, 26(10): 1933
[8］ Lee H T, Lim Y H, Kim B K, et al. The relationship between ambulatory arterial stiffness index and blood pressure variability in hypertensive patients[J]. Korean Circ J, 2011, 41(5): 235
[9］ Laugesen E, Erlandsen M, Knudsen S T, et al. Ambulatory arterial stiffness index: a composite index reflecting arterial stiffness, blood pressure variability and patients’ diurnal cycle[J]. J Hypertens, 2011, 29(11): 2278
[1０］ Parati G, Schillaci G. What are the real determinants of the ambulatory arterial stiffness index[J]. J Hypertens, 2012,30(3):472
[1１］ Ben-Dov I Z, Gavish B, Kark J D, et al. A modified ambulatory arterial stiffness index is independently associated with all-cause mortality[J]. J Human Hypertens, 2008, 22(11): 761

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备注/Memo

备注/Memo:

作者简介 陈云（1987-），女，硕士在读，研究方向：高血压、冠心病基础与临床研究；通信作者：袁如玉；E-mail：yuanruyu@medmail.com.cm。

常用功能

更新日期/Last Update: 2013-12-20