|本期目录/Table of Contents|

[1]罗 配,孙精通,王爱潮,等.单池药物溶出仿生系统考察卡马西平组合微丸的溶出特征[J].天津医科大学学报,2015,21(03):80-84.
 LUO Pei,SUN Jing-tong,WANG Ai-chao,et al.Dissolution of carbamazepine by single cell-DDASS[J].Journal of Tianjin Medical University,2015,21(03):80-84.
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单池药物溶出仿生系统考察卡马西平组合微丸的溶出特征()
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
80-84
栏目:
技术与方法
出版日期:
2015-05-20

文章信息/Info

Title:
Dissolution of carbamazepine by single cell-DDASS
文章编号:
1006-8147(2015)01-0080-04
作者:
罗 配12孙精通3王爱潮12秦 璐12何 新4刘志东12*
(1.天津市现代中药重点实验室制剂室-省部共建国家重点实验室培育基地,天津 300193;2.现代中药发现与制剂技术教育部工程研究中心,天津 300193;3. 天津中医药大学附属保康医院,天津 300193;4.天津中医药大学中药学院,天津 300193)
Author(s):
LUO Pei12 SUN Jing-tong3 WANG Ai-chao12QIN Lu12HE Xin4LIU Zhi-dong12
(1. Tianjin Modern Chinese Medicine Key Laboratory–Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China; 2. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China;
 3. Bao Kang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China)
关键词:
卡马西平单池药物溶出/吸收仿生系统高效液相色谱溶出度 药物评价
Keywords:
carbamazepine single cell drug dissolution and absorption simulating system high performance liquid chromatography dissolution drug revaluation
分类号:
R9
DOI:
-
文献标志码:
A
摘要:
目的:动态考察卡马西平组合微丸溶出特征。方法:采用Single cell-DDASS法,连续、动态地模拟组合微丸从胃移行至肠道崩解、释放,以模拟药物在人体中的溶出过程。联合使用高效液相色谱法测定药物含量随时间的变化情况。采用动力学方程拟合药物在体外的释放行为,根据拟合优度判定拟合情况。结果:卡马西平组合微丸累积释放最优拟合方程为一级释放动力学方程。ln(1-0.01Q)= -0.0229t+0.5521r=0.989 6)。释放机制为溶蚀机制。其释放度曲线拥有两个峰。峰谷波动小,释放时间延长。结论:卡马西平组合微丸具有一定的缓释效果。
Abstract:
Objective: To evaluate the dissolution behavior of the combined pellets of carbamazepine (CPC) on time. Methods: The formulation process from stomach to intestine was simulated by single the cell-DDASS. And the CPC was dissolved and released in the process. The high performance liquid chromatography method (HPLC) was applied to measure the content of carbamazepine to show the changes over time. And several mathematical models of drug release were used to fit the vitro release of the CPC. Therefore, the best simulations for the vitro release could be obtained by the degree of fitting. Results: The release pattern of the CPC in vitro could be described by first order kinetic equation. ln(1-0.01Q)= -0.0229t+0.5521(r=0.989 6). The release mechanism was based on the dissolution mechanism. Furthermore, with low volatility the release curve had two peaks, and CPC release time was increased. Conclusion: The CPC has certain slow-release effect.

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相似文献/References:

[1]罗 配,孙精通,王爱潮,等.单池药物溶出仿生系统考察卡马西平组合微丸的溶出特征[J].天津医科大学学报,2015,21(01):80.
 LUO Pei,SUN Jing-tong,WANG Ai-chao,et al.Dissolution of carbamazepine by single cell-DDASS[J].Journal of Tianjin Medical University,2015,21(03):80.

备注/Memo

备注/Memo:
作者简介 罗配(1988-),女,硕士在读, 研究方向:药物制剂;
通信作者刘志东,E-mail: lonerliuzd@163.com
更新日期/Last Update: 2015-01-22