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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年03期

页码:

63-64

栏目:

临床医学

出版日期:

2015-05-20

文章信息/Info

Title:

Relationship between  high-sensitivity C-reactive and complement 3 and disease activity in systemic lupus erythematosus

文章编号:

1006-8147（2015）01-0063-02

作者:

李晓洁; 周 蕾; 陈 宪; 王颖嫒

(天津医科大学总医院风湿免疫科 ,天津 300052)

Author(s):

LI Xiao-jie ; ZHOU Lei ; CHEN Xian ; WANG Ying-ai

(Department of Rheumatology and Immunology ,Tianjin Medical University ,General Hospital ,Tianjin 300052 ,China)

关键词:

红斑狼疮; 系统性; 超敏C反应蛋白; 补体C3; 疾病活动度

Keywords:

lupus erythematosus; systemic; high-sensitivity C-reactive protein;  complement 3; disease activity

分类号:

R593.24+1

DOI:

-

文献标志码:

A

摘要:

 目的 ：探讨超敏C反应蛋白(hsCRP)和补体C3与系统性红斑狼疮（SLE）疾病活动度间的关系。方法 ： 选取SLE患者101例，根据SLE疾病活动性指数（SLEDAI）评分分为缓解组（n=73）和活动组（n=28），应用免疫透射比浊法检测101例患者血浆hsCRP，应用速率放射比浊法检测患者血清C3，分组比较上述指标及其与疾病活动度的相关性。采用独立样本t检验、 X²检验和Pearson相关分析进行统计学分析。结果 ： 活动组SLE患者hsCRP水平高于缓解组[(9.03±6.84)mg/L] vs [(1.51±1.27)mg/L] ，活动组SLE患者补体C3水平低于缓解组[(677.00±389.75)mg/L]vs[(877.94±316.54)mg/L]，分别比较差异有统计学意义（P＜0.05）；hsCRP水平与SLEDAI评分呈正相关（r=0.649，P＜0.01），补体C3水平与SLEDAI评分呈负相关（r=-0.590，P＜0.01）。结论 ： HsCRP和补体C3水平与SLE疾病活动密切相关，可作为SLE患者疾病活动度监测和治疗效果的评估指标。

Abstract:

Objective ： To explore the relationship between the levels of high-sensitivity C-reactive protein（hsCRP），complement3(C3) and disease activity in patients with systemic lupus erythematosus(SLE).Methods ： A total of 101 patients with SLEwere divided into two groups in accordance with SLEDAI scores, the active group（n=28）and the remission group（n=73）.Plasma was assayed for hsCRP by immunological transmission turbidimetry,and serum was assayed for C3 by radiation rate nephelometry. All data were analyzed by Students’t test, Chi-squared test and Pearson regression analysis.Results： Patients in active group had higher hsCRP levels than patients in remisson group[（9.03±6.84）mg/L ] vs [(1.51±1.27）mg/L],and patients in active group had lower C3 levels than patients in remisson group[(677.00±389.75)mg/L] vs[(877.94±316.54)mg/L] differences were statistically significant(P＜0.05);hsCRP levels were positively correlated with SLEDAI score(r=0.649,P＜0.01),complement3 levels and SLEDAI score were negatively correlated(r=-0.590,P＜0.01).Conclusion : HsCRP and C3 are closely related with SLE activity and can be used as one of the indicators for SLE activity and the clinical result.

参考文献/References:

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[6]周明莉，蔡爱玲，王雪峰. 降钙素原及C反应蛋白测定在新生儿感染性疾病诊断中的应用[J]. 国际检验医学杂志, 2011,32(6):683

[7]Wadhwa A, Avasthi R, Ghambhir J K, et al. To study the prevalence and profile of metabolic syndrome,levels of hs-CRP,Lp(a)and serum ferritin in young Indian patients(<or=45 years)with acute myocardial infarction[J]. J Assoc Physicians India, 2013,61(6):384

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备注/Memo

备注/Memo:

 作者简介 李晓洁（1989-），女，硕士在读，研究方向：风湿病学；通信作者：周蕾，E-mail：yizhe1234@126.com。

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更新日期/Last Update: 2015-01-22