|本期目录/Table of Contents|

[1]梁柯欣 综述,赵晓赟 审校.颈动脉体功能异常相关疾病的病生理变化及射频消融治疗[J].天津医科大学学报,2023,29(04):445-448,452.
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颈动脉体功能异常相关疾病的病生理变化及射频消融治疗(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
29卷
期数:
2023年04期
页码:
445-448,452
栏目:
综述
出版日期:
2023-07-10

文章信息/Info

Title:
-
文章编号:
1006-8147(2023)04-0445-05
作者:
梁柯欣 综述赵晓赟 审校
天津医科大学胸科临床学院呼吸与危重症医学科,天津300222
Author(s):
-
关键词:
化学感受器颈动脉体自主神经功能障碍阻塞性睡眠呼吸暂停心力衰竭高血压射频消融
Keywords:
-
分类号:
R766 R541.6+1 R541.3 R454.1
DOI:
-
文献标志码:
A
摘要:
研究发现,颈动脉体功能增强导致的交感神经过度激活是阻塞性睡眠呼吸暂停、顽固性高血压、慢性心力衰竭的共同特征。颈动脉体射频消融技术通过减弱或消除颈动脉体增强的化学反射驱动,有助于恢复自主神经平衡和机体功能障碍,可延缓疾病的进展、提高生存质量,目前已成为相关疾病的治疗选择。本文阐述了颈动脉体功能增强所致的自主神经功能障碍及所介导的病生理学变化和分子机制以及颈动脉体射频消融治疗的应用现状。
Abstract:
-

参考文献/References:

[1] DEL R R,ANDRADE D C,LUCERO C,et al. Carotid body ablation abrogates hypertension and autonomic alterations induced by inter-mittent hypoxia in rats[J]. Hypertension,2016,68( 2):436-445.
[2] REY S,TARVAINEN M P,KARJALAINEN P A,et al. Dynamic time-varying analysis of heart rate and blood pressure variability in cats exposed to short-term chronic intermittent hypoxia [J]. Am J Physiol Regul Integr Comp Physiol,2008,295( 1):R28-R37.
[3] SANCHEZ-DE-LA-TORRE M,SANCHEZ-DE-LA-TORRE A, BERTRAN S,et al. Effect of obstructive sleep apnoea and its treat-ment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome ( ISAACC study):a randomised controlled trial[J].LancetRespirMed, 2020,8( 4):359-367.
[4] PRABHAKAR N R,PENG Y J,NANDURI J. Hypoxia-inducible factors and obstructive sleep apnea[J]. J Clin Invest,2020,130(10):5042-5051.
[5] PENG Y J,NANDURI J,RAGHURAMAN G,et al. Role of oxidative stress-induced endothelin-converting enzyme activity in the alter-ation of carotid body function by chronic intermittent hypoxia[J]. Exp Physiol,2013,98( 11):1620-1630.
[6] LI J,YANG S,YU F,et al. Endothelin-1 enhanced carotid body chemosensory activity in chronic intermittent hypoxia through PLC, PKC and p38MAPK signaling pathways[J]. Neuropeptides,2019, 74:44-51.
[7] SHELL B,FARMER G E,NEDUNGADI T P,et al. Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hy-poxia-induced hypertension [J]. Am J Physiol Regul Integr Comp Physiol,2019,316( 5):R651-R665.
[8] DEL R R,MOYA E A,ITURRIAGA R. Differential expression of pro-inflammatory cytokines,endothelin-1 and nitric oxide synthas-es in the rat carotid body exposed to intermittent hypoxia[J]. Brain Res,2011,1395:74-85.
[9] YUAN G,PENG Y J,KHAN S A,et al. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea[J]. Sci Signal,2016,9( 441):a80.
[10] DEL R R,MOYA E A,PARGA M J,et al. Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia [J]. Eur Respir J,2012,39( 6):1492-1500.
[11] DESPAS F,LAMBERT E,VACCARO A,et al. Peripheral chemore-flex activation contributes to sympathetic baroreflex impairment in chronic heart failure[J]. J Hypertens,2012,30( 4):753-760.
[12] DEL R R,MARCUS N J,SCHULTZ H D. Carotid chemoreceptor ab-lation improves survival in heart failure:rescuing autonomic control of cardiorespiratory function [J]. J Am Coll Cardiol,2013,62( 25):2422-2430.
[13] NIEWINSKI P,JANCZAK D,RUCINSKI A,et al. Carotid body re-moval for treatment of chronic systolic heart failure[J]. Int J Cardiol, 2013,168( 3):2506-2509.
[14] MARCUS N J,DEL R R,DING Y,et al. KLF2 mediates enhanced chemoreflex sensitivity,disordered breathing and autonomic dysreg-ulation in heart failure[J]. J Physiol,2018,596( 15):3171-3185.
[15] SINSKI M,LEWANDOWSKI J,PRZYBYLSKI J,et al. Deactivation of carotid body chemoreceptors by hyperoxia decreases blood pressure in hypertensive patients[J]. Hypertens Res,2014,37( 9):858-862.
[16] ABDALA A P,MCBRYDE F D,MARINA N,et al. Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat[J]. J Physiol,2012,590( 17):4269-4277.
[17] PIJACKA W,MCBRYDE F D,MARVAR P J,et al. Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats[J]. J Physiol,2016,594( 21):6255-6266.
[18] PIJACKA W,MORAES D J,RATCLIFFE L E,et al. Purinergic re-ceptors in the carotid body as a new drug target for controlling hy-pertension[J]. Nat Med,2016,22( 10):1151-1159.
[19] XUE Q,WANG R,WANG L,et al. Downregulating the P2X3 recep-tor in the carotid body to reduce blood pressure via acoustic gene delivery in canines[J]. Transl Res,2021,227:30-41.
[20] ZHENG F,MU S,RUSCH N J. Leptin activates trpm7 channels in the carotid body as a mechanism of obesity-related hypertension[J]. Circ Res,2019,125( 11):1003-1005.
[21]眭清永,王新文,杨旸曈,等.颈部CTA标准方案改进联合靶扫
[22] ITURRIAGA R. Translating carotid body function into clinical medicine[J]. J Physiol,2018,596( 15):3067-3077.
[23] ITURRIAGA R. Carotid body ablation:a new target to address cen-tral autonomic dysfunction[J]. Curr Hypertens Rep,2018,20(6):53.
[24] NARKIEWICZ K,RATCLIFFE L E,HART E C,et al. Unilateral carotid body resection in resistant hypertension:a safety and feasi-bility trial[J]. JACC Basic Transl Sci,2016,1( 5):313-324.
[25] SCHLAICH M,SCHULTZ C,HERING D,et al. First in-human e-valuation of a transvenous carotid body ablation device to treat pa-tients with resistant hypertension[J]. Heart Lung Circ,2017,26:S57.
[26] SCHLAICH M,SCHULTZ C,SHETTY S,et al. 1416 Transvenous carotid body ablation for resistant hypertension:main results of a multicentre safety and proof-of-principle cohort study[J]. Eur Heart J,2018,39( Suppl_1):267.
[27] NIEWINSKI P,JANCZAK D,RUCINSKI A,et al. Dissociation be-tween blood pressure and heart rate response to hypoxia after bilat-eral carotid body removal in men with systolic heart failure[J]. Exp Physiol,2014,99( 3):552-561.
[28] NIEWINSKI P,JANCZAK D,RUCINSKI A,et al. Carotid body re-section for sympathetic modulation in systolic heart failure:results from first-in-man study[J]. Eur J Heart Fail,2017,19( 3):391-400.
[29] NIEWINSKI P,TUBEK S,PATON J,et al. Oxygenation pattern and compensatory responses to hypoxia and hypercapnia following bilat-eral carotid body resection in humans[J]. J Physiol,2021,599( 8):2323-2340.

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备注/Memo

备注/Memo:
基金项目: 国家重点研发计划项目(2019YFC0119400);天津市医学重点学(专)科建设项目;天津市卫生健康科技项目(KJ2001 津市津南区科技计划项目(20200116)
作者简介: 梁柯欣(1998-),女,硕士在读,研究方向:呼吸危重症、睡眠呼吸疾病;
通信作者:赵晓赟,E-mail:zxydoctor@163.com。
更新日期/Last Update: 2023-07-10