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[1]张莹华 综述,马勇杰 审校.ITSN1蛋白磷酸化的研究进展[J].天津医科大学学报,2019,25(06):666-669.
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ITSN1蛋白磷酸化的研究进展(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年06期
页码:
666-669
栏目:
综述
出版日期:
2019-11-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2019)06-0666-04
作者:
张莹华 综述马勇杰 审校
(天津医科大学肿瘤医院细胞生物学实验室,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学研究中心,天津300060)
Author(s):
-
关键词:
ITSN1磷酸化生物学疾病
Keywords:
-
分类号:
Q51
DOI:
-
文献标志码:
A
摘要:
Intersectin(ITSN),又称EHSH1、Dap60和Ese-1,该基因位于人体第21号染色体上,编码一种高度保守的多结构域细胞衔接蛋白,主要调节胞吞和胞吐、肌动蛋白细胞骨架重排等生物学过程。磷酸化是蛋白质翻译后修饰的主要类型,受到蛋白激酶和磷酸酶的共同调节而保持一种动态平衡,在正常生命活动乃至肿瘤发生中发挥作用。本文总结了ITSN1磷酸化后参与的生物学过程及在一些疾病中的作用,希望能进一步了解磷酸化是如何调节ITSN1蛋白的功能。
Abstract:
-

参考文献/References:

[1] Gubar O, Morderer D, Tsyba L, et al. Intersectin: the crossroad between vesicle exocytosis and endocytosis[J]. Front Endocrinol (Lausanne), 2013, 4(109):1
[2] Gryaznova T, Gubar O, Burdyniuk M,et al. WIP/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions [J]. Gene, 2018, 674(2):49
[3] Alvisi G, Paolini L, Contarini A, et al.Intersectin goes nuclear: secret life of an endocytic protein[J]. Biochem J, 2018,475(8):1455
[4] Sharma K, Souza R C,Tyanova S, et al. Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-Based signaling [J]. Cell Rep,2014,8(5):1583
[5] Beausoleil S A, Jedrychowski M, Schwartz D,et al.Large-scale characterrization of HeLa cell nuclear phosphoproteins[J]. Pro Nati Acad Sci USA, 2004, 101(33):12130
[6] Dephoure N, Zhou C S, Villen J, et al. A quantitative atlas of mitotic phosphorylation [J]. Pro Nati Acad Sci USA,2008,105(31):10762
[7] Uckuna F M, Ma H, Z J, et al.Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function Of Ikaros[J].Pro Nati Acad Sci USA, 2012,109(44):18072
[8] Kettenbach A N, Schweppe D K,Faherty B K, et al. Quantitative phosphoproteomics identifies substrates and functional modules of aurora and Polo-Like kinase activities in mitotic cells[J]. Sci Signal,2013,4(179):1
[9] 徐婷婷. c-Src通过磷酸化激活HK促进肿瘤的发生和转移[J].厦门大学学报(自然科学版),2017, 56(2):1
[10] Singec I, CrainA M, Hou J J,et al.Quantitative analysis of human pluripotency and neural specification by in-depth(Phospho)proteomic profiling [J]. Stem Cell Reports, 2016,7(3):527
[11] Brill L M, Xiong W, Lee K B, et al.Phosphoproteomic analysis of human embryonic stem cells[J]. Cell Stem Cell, 2009,5(2): 204
[12] Graaf E L,Giansanti P, Marrten Altelaar A F,et al.Single-step enrichment by Ti4-IMAC and label-free quantitation enables in-depth monitoring of phosphorylation dynamics with high reproducibility and temporal resolution[J]. Mol Cell Protemics,2014,13(9): 2426
[13] Giansanti P, Aye T T, Toorn H, et al.An augmented multiple-protease-based human phosphopeptide atlas[J]. Cell Rep, 2015, 11(11):1834
[14] Ruse C I,McClatchy D B,Lu B,et al.Motif-specific sampling of phosphoproteomes [J]. J Proteome Res, 2008 ,7(5):2140
[15] Drake J M, Paull E O,Graham N A,et al. Phosphoproteome integration reveals patient-specific networks in prostate cancer[J]. Cell, 2016, 166(4):1041
[16] Huang H, Petersen M H, Ibanez-Vea M,et al.Simultaneous enrichment of cysteinecontaining peptides and phosphopeptides using a cysteine-specific phosphonate adaptable tag(CysPAT) in combination with titanium dioxide(TiO2) chromatography[J]. Mol Cell Protemics , 2016, 15(10):3282
[17] Schreiber T B, Usbacher N M, Keri G,et al.An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling[J]. Mol Cell Protemics, 2010,9(6):1047
[18] Boeing S,Williamson L, Encheva V, et al. Multiomic analysis of the UV Induced DNA damage response[J]. Cell Rep ,2016,15(7):1597
[19] Wilhelm M, Schleg J,Hahne H,et al.Mass-spectrometry-based draft of the human proteome[J]. Nature, 2014,509(7502):582
[20] 张东升,周方正,王小聪,等. CDX1 对结直肠癌细胞增殖凋亡及p38MAPK 磷酸化水平的影响[J].现代肿瘤医学, 2018,26(17):2665
[21] 胡军,程妮,钟占强,等. CD44v6 通过 Akt 信号通路调节胶质瘤细胞生长[J].现代肿瘤医学,2018,26(19):3022
[22] 黄平,李彦英,李玲玲,等.ATIP3a-HMGA2-ERK信号通路对卵巢上皮细胞癌顺铂耐药性的影响[J].河北医科大学学报,2018, 39(10):1179
[23] Soderholm S, Kainov D E, Hman T O,et al. Phosphoproteomics to characterize host response during influenza a virus infection of human macrophages[J] . Mol Cell Protemics, 2016,15(10):3203
[24] Dergai O,Dergai M,Skrypkina I,et al.The LMP2A protein of Epstein-Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases [J]. Cell Signalling, 2013,25(1):33
[25] Guo J H ,Cui Y Z,Yan Z Q ,et al.Phosphoproteome characterization of human colorectal cancer SW620 cell-derived exosomes and new phosphosite discovery for C-HPP[J]. J Proteome Res, 2016,15(11):4060
[26] Shiromizu T, Adachi J,Watanabe S ,et al.Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the phospho site plus database as part of the chromosome-centric human proteome project [J]. J Proteome Res, 2013,12(6):2414
[27] Tsai C F,Wang Y T,Yen H Y,et al.Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics[J]. Nat Commun, 2015,6:1
[28] Klammer M, Kaminski M, Zedler A, et al. Phosphosignature predicts dasatinib response in non-small cell lung cance[J]. Mol Cell Protemics, 2012,11(9):651
[29] Schweppe D K, Rigas J R,Gerber S A. Quantitative phospho- proteomic profiling of human non-small cell lung cancer tumors[J]. J Proteomics, 2013,91:286
[30] Stahl S, Branca R M , Efazat G ,et al.Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor [J]. J Proteome Res, 2011, 10(5):2566
[31] Herskowitz J H,Seyfried N T,Duong D M,et al.Phosphoproteomic analysis reveals site-specific changes inGFAP and NDRG2 phosphorylation in frontotemporal lobardegeneration[J]. J Proteome Res, 2010, 9(12):6368
[32] Tan H Y, Wu Z P, Wang H, et al.Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome [J]. Proteomics, 2015,15(2-3):500
[33] Mertins P, Yang F, Liu T, et al.Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels[J]. Mol Cell Protemics,2014,13(7):1690
[34] Mertins P, Mani D R, Ruggles K V, et al.Proteogenomics connects somatic mutations to signaling in breast cancer [J]. Nature, 2016, 534(7605):55

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金面上项目(81572851)
作者简介 张莹华(1990-),女,硕士在读,研究方向:生物化学与分子生物学;通信作者:马勇杰,E-mail:yongjiemagu@aliyun.com。
更新日期/Last Update: 2020-01-20