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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年04期

页码:

315-322

栏目:

出版日期:

2018-07-20

文章信息/Info

Title:

Analysis of prognostic factors for 389 patients with oral squamous cell carcinoma

作者:

张 华; 杨 蓉; 叶贝贝; 张文超

天津医科大学肿瘤医院颌面耳鼻喉肿瘤科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心，天津 300060

Author(s):

ZHANG Hua; YANG Rong; YE Bei-bei;  ZHANG Wen-chao

Department of Maxillofacial, Ear, Nose and Throat Oncology, Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China

关键词:

口腔鳞状细胞癌; 病理; 生存分析; 预后

Keywords:

oral squamous cell carcinoma;  pathology;  survival analysis;  prognosis

分类号:

R739.85

DOI:

-

文献标志码:

Ａ

摘要:

目的：探讨影响口腔鳞状细胞癌（OSCC）患者预后的因素。方法：回顾分析389例初诊OSCC患者的临床病理及随访资料，利用SPSS 20.0及STATA软件行统计学分析。结果：OSCC患者的3年总生存率（OSR）和3年无病生存率（DFSR）分别为74.3%、73.5%，5年OSR和5年DFSR分别为52.7%、44.5%。单因素分析表明，cN分期、pN分期、临床分期、分化程度、淋巴结结外侵犯（ENE）与OSCC预后显著相关（P＜0.05）。COX回归分析显示，临床分期、淋巴结结外侵犯是独立预后影响因素（P＜0.05）。χ2检验表明，临床分期、pN分期、淋巴结结外侵犯与复发密切相关。结论：OSCC 5年生存率相对较低。中晚期患者淋巴结结外侵犯明显，严重影响预后。早期发现和诊治可降低OSCC复发率，从而提高患者生存率。

Abstract:

Objective: To investigate the prognostic factors for oral squamous cell carcinoma (OSCC) patients. Methods: Clinicopathological data and follow-up data of 389 OSCC patients newly diagnosed with OSCC were retrospectively analyzed. SPSS 20.0 and STATA software were used for statistical analysis. Results: The 3-year overall survival rate (OSR) and 3-year disease-free survival rate (DFSR) for OSCC patients were 74.3% and 73.5%, respectively. The 5-year OSR and 5-year DFSR for OSCC patients were 52.7% and 44.5%, respectively. The univariate analysis showed that cN stage, pN stage, clinical stage, differentiated degree, and extranodal extension（ENE） were significantly associated with prognosis（P＜0.05）. COX regression analysis revealed that clinical stage and ENE were the independent prognostic factors（P＜0.05）. Chi-square test demonstrated that clinical stage, pN stage, and ENE were closely related to recurrence. Conclusion: The 5-year survival rate of OSCC was relatively low. ENE was marked in advanced OSCC patients, which seriously could affect the prognosis. Early detection and treatment could reduce the recurrence rate of OSCC, thus improving the survival rate for OSCC patients.

参考文献/References:

[1] Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012[J]. Int J Cancer, 2015,136(5):E359
[2] Lippman S M, Hong W K. Molecular markers of the risk of oral cancer[J]. N Engl J Med, 2001,344(17):1323
[3] Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013,63(1):11
[4] Warnakulasuriya S. Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival[J]. Oral Oncol, 2010,46(6):407
[5] Siegel R L, Miller K D, Jemal A. Cancer statistics, 2015[J]. CA Cancer J Clin, 2015,65(1):5
[6] Garzino-Demo P, Dell’Acqua A, Dalmasso P, et al. Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma[J]. J Craniomaxillofac Surg, 2006,34(6):344
[7] Gallo O, Bianchi S, Porfirio B. Bcl-2 overexpression and smoking history in head and neck cancer[J]. J Natl Cancer Inst, 1995,87(13):1024
[8] Deleyiannis F W, Thomas D B, Vaughan T L, et al. Alcoholism: independent predictor of survival in patients with head and neck cancer[J]. J Natl Cancer Inst, 1996,88(8):542
[9] van Imhoff L C, Kranenburg G G, Macco S, et al. Prognostic value of continued smoking on survival and recurrence rates in patients with head and neck cancer: a systematic review[J]. Head Neck, 2016,38 Suppl 1:E2214
[10] Adelstein D, Gillison M L, Pfister D G, et al. NCCN Guidelines Insights: Head and Neck Cancers, Version 2. 2017[J]. J Natl Compr Canc Netw, 2017,15(6):761
[11] Jalouli J, Ibrahim S O, Mehrotra R, et al. Prevalence of viral (HPV, EBV, HSV) infections in oral submucous fibrosis and oral cancer from India[J]. Acta Otolaryngol, 2010,130(11):1306
[12] Ostwald C, Rutsatz K, Schweder J, et al. Human papillomavirus 6/11, 16 and 18 in oral carcinomas and benign oral lesions[J]. Med Microbiol Immunol, 2003,192(3):145
[13] Gupta S, Gupta S. Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders: A review of the literature[J]. Indian J Dent, 2015,6(2):91
[14] Chen F, Yan L, Liu F, et al. Oral human papillomavirus infection, sexual behaviors and risk of oral squamous cell carcinoma in southeast of China: A case-control study[J]. J Clin Virol, 2016,85:7
[15] Layland M K, Sessions D G, Lenox J. The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+[J]. Laryngoscope, 2005,115(4):629
[16] Capote-Moreno A, Naval L, Munoz-Guerra M F, et al. Prognostic factors influencing contralateral neck lymph node metastases in oral and oropharyngeal carcinoma[J]. J Oral Maxillofac Surg, 2010,68(2):268
[17] Wang B, Zhang S, Yue K, et al. The recurrence and survival of oral squamous cell carcinoma: a report of 275 cases[J]. Chin J Cancer, 2013, 32(11):614
[18] 孙晓玉. cN0口腔鳞状细胞癌隐匿性淋巴结转移的临床解析[D]. 青岛大学, 2017.
[19] 杨安奎, 陈福进, 李秋梨, 等. 舌鳞癌隐匿性颈淋巴结转移的特点及其对患者预后的影响[J]. 癌症, 2003(5):541
[20] Feng Z, Li J N, Li C Z, et al. Elective neck dissection versus observation in the management of early tongue carcinoma with clinically node-negative neck: a retrospective study of 229 cases[J]. J Craniomaxillofac Surg, 2014,42(6):806
[21] Huang S F, Kang C J, Lin C Y, et al. Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection[J]. Cancer, 2008, 112(5):1066
[22] Shoaib T, Soutar D S, Prosser J E, et al. A suggested method for sentinel node biopsy in squamous cell carcinoma of the head and neck[J]. Head Neck, 1999,21(8):728
[23] Huang S H, O’Sullivan B. Overview of the 8th Edition TNM Classification for Head and Neck Cancer[J]. Curr Treat Options Oncol, 2017, 18(7):40
[24] Lydiatt W M, Patel S G, O’Sullivan B, et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual[J]. CA Cancer J Clin, 2017, 67(2):122
[25] Tong X J, Shan Z F, Tang Z G, et al. The impact of clinical prognostic factors on the survival of patients with oral squamous cell carcinoma[J]. J Oral Maxillofac Surg, 2014,72(12):2491
[26] Vazquez-Mahia I, Seoane J, Varela-Centelles P, et al. Predictors for tumor recurrence after primary definitive surgery for oral cancer[J]. J Oral Maxillofac Surg, 2012,70(7):1724
[27] Licitra L, Grandi C, Guzzo M, et al. Primary chemotherapy in resectable oral cavity squamous cell cancer: a randomized controlled trial[J]. J Clin Oncol, 2003,21(2):327
[28] Bossi P, Lo V S, Guzzo M, et al. Preoperative chemotherapy in advanced resectable OCSCC: long-term results of a randomized phase III trial[J]. Ann Oncol, 2014,25(2):462
[29] Marta G N, Riera R, Bossi P, et al. Induction chemotherapy prior to surgery with or without postoperative radiotherapy for oral cavity cancer patients: Systematic review and meta-analysis[J]. Eur J Cancer, 2015,51(17):2596

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备注/Memo

备注/Memo:

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常用功能

更新日期/Last Update: 2018-07-20