|本期目录/Table of Contents|

[1]李亚新,杨庆利,陈虹,等.复方甘草软胶囊的处方与工艺研究[J].天津医科大学学报,2018,24(03):259-262.
　LI Ya-xin,YANG Qing-li,CHEN Hong,et al.Study on prescription and preparation of compound licorice soft capsule[J].Journal of Tianjin Medical University,2018,24(03):259-262.
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复方甘草软胶囊的处方与工艺研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年03期
页码:
259-262
栏目:
技术与方法
出版日期:
2018-05-20

文章信息/Info

Title:
Study on prescription and preparation of compound licorice soft capsule
作者:
李亚新1; 4; 杨庆利2; 陈虹3; 高颖3
1.天津医科大学研究生院，天津 300070； 2.武警甘肃总队酒泉市支队，酒泉 735000；3.武警后勤学院生药学和药剂学教研室，天津 300309；4. 武警后勤学院附属医院药材科，天津 300162
Author(s):
LI Ya-xin1; 4;  YANG Qing-li2;  CHEN Hong3;  GAO Ying3
1. Graduate School, Tianjin Medical University, Tianjin 300070, China; 2. Armed Police Gansu Corps Jiuquan City Detachment, Jiuquan 735000, China; 3. Department of Pharmacognosy and Pharmacy, Logistics University of People’s Armed Police Force, Tianjin 300309, China; 4. Department of Pharmacy, Affiliated Hospital of Logistics University of People’s Armed Police Force, Tianjin 300162, China
关键词:
甘草; 软胶囊; 正交设计; 工艺研究
Keywords:
Chinese herb Glycyrrhiza glabra;  soft capsule;  orthogonal design;  preparation research
分类号:
R283.6
DOI:
-
文献标志码:
A
摘要:
目的：优选复方甘草软胶囊内容物的处方及工艺。方法：采用单因素筛选方法和正交试验L9（34）法，以内容物沉降体积比和再分散性为考察指标，确定复方甘草软胶囊处方及制备工艺。结果：以PEG400为分散介质，药材冻干粉粉末过120目筛，助悬剂选择蜂蜡，润湿剂选择大豆卵磷脂；药粉与聚乙二醇400用量比为1:1.25，蜂蜡用量为2%，大豆卵磷脂用量为0.4%时，制得的内容物混悬液最为稳定。结论：该方法制得的软胶囊内容物均匀、稳定、流动性好。
Abstract:
Objective: To optimize the prescription and preparation of compound licorice soft capsule content. Methods: Single factor screening method and orthogonal test L9(34) method were used to determine the prescription and preparation process of compound licorice soft capsules with the sediment volume ratio and re-dispersibility of the contents as indicators. Results: The PEG400 was used as the dispersion medium. The lyophilized powder was passed through a 120-mesh sieve. The beeswax was selected as the suspending agent, and the soy lecithin was selected as the wetting agent. The ratio of the powder to the PEG400 was 1:1.25. The amount of beeswax was 2%, the amount of soybean lecithin was 0.4%. The resulting content suspension is the most stable. Conclusion: The soft capsule content of this method is well-distributed and stable with high fluidity.

参考文献/References:

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备注/Memo

备注/Memo:
文章编号 1006-8147(2018)03-0259-04
基金项目 国家“十二五”科技重大专项基金资助项目（ 2012ZX
09103201-029）
作者简介 李亚新（1985-），女，药师，硕士在读，研究方向：药物化学；通信作者：高颖，E-mail:gying77@163.com。
更新日期/Last Update: 2018-05-20