|本期目录/Table of Contents|

[1]张婷婷,张广华.右美托咪定持续输注对结肠癌手术麻醉的影响[J].天津医科大学学报,2017,23(01):62-64.
点击复制

右美托咪定持续输注对结肠癌手术麻醉的影响(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23卷
期数:
2017年01期
页码:
62-64
栏目:
临床医学
出版日期:
2017-01-16

文章信息/Info

Title:
-
文章编号:
1006-8147(2017)01-0062-03
作者:
张婷婷张广华
(天津医科大学肿瘤医院麻醉科,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津300060)
Author(s):
-
关键词:
右美托咪定七氟烷躁动结肠癌
Keywords:
-
分类号:
R614.2
DOI:
-
文献标志码:
A
摘要:
目的:探讨右美托咪定持续输注对结肠癌患者血流动力学、七氟烷用量、苏醒时间及术后镇静-躁动评分影响。方法:80例择期结肠癌手术患者随机分为右美托咪定组(D组)和对照组(C组)。D组予右美托咪定1μg/㎏后以0.5 μg/(㎏ h)速度持续输注,C组予等容量生理盐水。术中调节七氟烷吸入浓度,维持脑电双频指数(BIS)为50±5。记录两组患者入室后(T0)、诱导前(T1)、诱导后(T2)、插管后即刻(T3)、插管后3 min(T4)、手术开始(T5)、拔管时(T6)血压及心率变化。记录手术时间、七氟烷用量、苏醒时间及术后镇静-躁动评分。结果:与T0相比,C组血压、心率T1到T5各时点先明显下降后明显升高(P<0.05),D组变化不明显;组间比较有明显差异(P<0.05)。与C组相比,D组七氟烷用量少(P<0.05)。镇静-躁动评分C组为(5.30±0.26)分,D组为(3.50±0.20)分,D组显著低于C组(P<0.05)。两组手术时间及术后苏醒时间无明显差别。结论:结肠癌患者术中持续输注右美托咪定,有利于维持患者血流动力学稳定,减少七氟烷用量,预防术后躁动发生,且对术后苏醒时间无影响。
Abstract:
-

参考文献/References:

[1] Yin M H, Zhang J, Cai C H. The clinical research on effects of different anesthetic techniques on hemorheology in patients undergoing total hip replacement[J]. China Prac Med,2010,5( 10) : 23

[2] Agarwal S, Aggarwal R, Gupta P. Dexmedetomidine prolongs the effect of bupivacaine in supraclavicular brachial plexus block[J]. Anaesthesio Clin Pharmacol, 2014,30(1):36

[3]Menda F, Koner O, Sayin M , et al. Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG[J]. Ann Card Anaesth , 2010,13 (1):16

[4] Talke P, Lobo E, Brown R, et al. Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans[J]. Anesthesiology 2003 ,99 (1):65

[5] 巫绍汝,成浩,嵇富海,等. 右美托咪定对心脏手术患者术中血压和心率影响的Meta分析[J]. 临床麻醉学杂志, 2015,31(2):125

[6] Chu K S,Wang F Y, Hs H T, et al. The effectiveness of Dexmedetomidine infsion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation[J]. Eur J Anaesthesiol, 2010,27(1):36

[7] Cho J S, Kim S H, Shin S, et al. Effects of Dexmedetomidine on changs in heart rate variability and hemodynamics during tracheal intubation [J]. Am J Ther, 2016,23(2):369

[8] 庞国勋,高冬艳,张煜东,等.不同剂量右美托咪啶对七氟烷抑制切皮诱发患者体动反应肺泡气最低有效浓度的影响[J]. 临床麻醉学杂志, 2012,32(7):808

[9] Patel C R,Engineer S R ,Shah B J, et al. The effect of Dexmedetomidine continuous infusion as an adjuvant to general anesthesia on sevoflurane requirements:A study based on entropy analysis[J]. Anaesthesiol Clin Pharmacol, 2013,29(3):318

[10] Ohtani N, Kida K, Shoji K, et al. Recovery profiles from Dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery[J]. Anesth Analg, 2008,107:1871

[11] 陈恭达,夏瑞,毛庆军,等.右美托咪定联合喉罩在困难气道插管中的应用[J].临床麻醉学杂志, 2013,29(2):129

[12] 邵娴,张瑾,邢玉英,等.右美托咪定对妇科腹腔镜手术患者全麻苏醒期的影响[J]. 临床麻醉学杂志, 2014,30(1):49

相似文献/References:

[1]许德芳,余剑波,牟 戎,等.不同全麻药物对体外循环患者氧化应激反应影响的比较[J].天津医科大学学报,2015,21(04):328.
 XU De-fang,YU Jian-bo,MU Rong,et al.Effect of different anesthesia on perioperative oxidative stress in patients with coronary artery bypass grafting[J].Journal of Tianjin Medical University,2015,21(01):328.
[2]王 鹏.右美托咪定预处理对止血带性心肌损伤的保护作用[J].天津医科大学学报,2016,22(01):64.
[3]王 鹏,李庆丰,林 红,等.右美托咪定联合罗哌卡因局部浸润对鼻内镜手术后镇痛的影响[J].天津医科大学学报,2016,22(05):457.
[4]陈 鹏,王 鹏.超声引导胸椎旁神经阻滞用于非体外循环冠脉旁路移植术患者超前镇痛的效果[J].天津医科大学学报,2017,23(05):453.
[5]黄庆先,王鹏.右美托咪定对行肿瘤细胞减灭术联合术中腹腔热灌注化疗老年患者术后认知功能的影响[J].天津医科大学学报,2018,24(02):174.
[6]朱敏,于洪丽,孙英,等.α7nAChR-HDAC6通路在右美托咪啶降低幼鼠七氟烷神经毒性中的作用[J].天津医科大学学报,2020,26(05):418.
 ZHU Min,YU Hong-li,SUN Ying,et al.Dexmedetomidine ameliorates sevoflurane-induced neurotoxicity in neonatal mice via the pathway of α7nAChR-HDAC6[J].Journal of Tianjin Medical University,2020,26(01):418.
[7]齐颖,陈兵.盐酸右美托咪定对脓毒症急性肺损伤小鼠基质金属蛋白酶7抑制作用研究[J].天津医科大学学报,2022,28(01):65.
 QI Ying,CHEN Bing.Inhibitory effect of dexmedetomidine on serum matrix metalloproteinase 7 in mice with septic acute lung injury[J].Journal of Tianjin Medical University,2022,28(01):65.
[8]李萌,房怿,刘洪霞,等.心率变异性分析对右美托咪定术前抗焦虑作用评价[J].天津医科大学学报,2022,28(01):77.
 LI Meng,FANG Yi,LIU Hong-Xia,et al.Analysis of heart rate variability evaluate dexmedetomidine for preoperative anxiety[J].Journal of Tianjin Medical University,2022,28(01):77.
[9]于乐昌,杨立恒,张蔷.右美托咪定对老年脓毒症机械通气患者炎症和预后的影响[J].天津医科大学学报,2022,28(04):409.
 YU Le-chang,YANG Li-heng,ZHANG Qiang.Effect of dexmedetomidine on inflammation and prognosis in elderly patients with sepsis requiring mechanical ventilation[J].Journal of Tianjin Medical University,2022,28(01):409.

备注/Memo

备注/Memo:
作者简介 张婷婷(1990-),女,硕士在读,研究方向:围术期麻醉质量;通信作者:张广华,E-mail:zghttyyyy@hotmail.com。
更新日期/Last Update: 2017-01-16