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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年03期

页码:

230-233

栏目:

临床医学

出版日期:

2016-05-20

文章信息/Info

Title:

Study on the relationship between body adiposity index and diabetic nephropathy in patients with type 2 diabetes mellitus

文章编号:

1006-8147（2016）03-0230-04

作者:

姚 旻¹; 2; 赵爱源³; 张晓会⁴; 李红涛²; 张 宏⁴

(1.天津医科大学研究生院,天津 300070; 2.武警天津总队医院内二科,天津 300252;3.武警后勤学院科研部,天津 300309;4.天津医科大学代谢病医院内分泌研究所,卫生部激素与发育重点实验室,天津 300070)

Author(s):

YAO Min¹; 2;  ZHAO Ai-yuan³;  ZHANG Xiao-hui⁴;  LI Hong-tao²;  ZHANG Hong⁴

(1.Graduate School , Tianjin Medical University , Tianjin 300070 China;2.Department of Internal Medicine, Tianjin Municipal Corps Hospital of Chinese Peoples Armed Police Forces, Tianjin 300252, China;3.Department of Scientific Research, Logistics University of Chinese Peoples Armed Police Forces, Tianjin 300309, China;4.Key Laboratory of Hormones and Development(Ministry of Health)Metabolic Disease HospitalEndocrinology InstituteTianjin Medical UniversityTianjin 300070,China)

关键词:

人体肥胖指数; 糖尿病; 2型; 糖尿病肾病; 身体脂肪含量

Keywords:

body adiposity index;  diabetic nephropathy;  diabetes mellitus;  type 2;  body fat content

分类号:

R587.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨新人体测量学指标-人体肥胖指数（BAI）与2型糖尿病肾病的相关性。方法：413例2型糖尿病患者，以是否患糖尿病肾病分为糖尿病肾病组（DN组）和非糖尿病肾病组（NDN组）。比较不同组间的BAI差异，采用Logistic回归分析BAI与糖尿病肾病的相关性。结果： DN组病程、BAI、平均动脉压（MBP）、糖化血红蛋白（HbA1C）、纤维蛋白原均明显高于NDN组（P<0．01）。偏相关分析表明DN与BMI、BAI、MBP、HbA1C、UA、FIB呈显著正相关（P<0．05）；与HDL-C呈显著负相关（P<0．01）。Logistic回归分析表明，病程、MBP、HbA1C、FIB、 BAI是糖尿病肾病的危险因素（P<0．05）。结论： DN组BAI高于NDN组，BAI与2型糖尿病肾病相关，BAI是糖尿病患者合并DN的危险因素。

Abstract:

Objective ：To explore the relationship between the new index of anthropometry, also called Body adiposity index, and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: Four hundred and thirteen type 2 diabetic patients were divided into diabetic nephropathy group(DN group) and non-diabetic nephropathy group(NDN group). Differences in BAI between the two groups were compared. Logistic regression was used to analysis the correlation between BAI and DN. Results: Compared with NDN group, the course of disease, BAI, mean arterial pressure (MBP), glycosylated hemoglobin (HbA1C) and fibrinogen increased significantly in DN group （P<0．01）. Partial correlation analysis revealed that there were positive correlations between DN and BMI, BAI, MBP, HbA1C, UA , FIB （P<0．05）, and negative correlation between DN and HDL-C （P<0．01）. Multiple logistic regression analysis revealed that the course of disease , MBP,HbA1C,FIB, BAI were risk factors of DN（P<0．05）.Conclusion: BAI is higher in DN group than in NDN group. A positive correlation could exist between DN and BAI. BAI may be a risk factor of DN in patients with diabetes mellitus.

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备注/Memo

备注/Memo:

作者简介 姚旻（1979-），女，主治医师，博士在读，研究方向：糖尿病及其慢性并发症的发病机制研究;通信作者：张宏，E-mail:zh80008@163.com。

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更新日期/Last Update: 2016-05-25