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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年04期

页码:

328-331

栏目:

临床医学

出版日期:

2015-07-15

文章信息/Info

Title:

Effect of different anesthesia on perioperative oxidative stress in patients with coronary artery bypass grafting

文章编号:

1006-8147（2015）04-0328-04

作者:

 许德芳¹; 2;  余剑波²; 牟 戎¹; 张 丽¹; 王冰舒¹; 周春晶¹ ; 王 方¹

(1.天津医科大学第四中心临床学院麻醉科,天津市第四中心医院麻醉科,天津300140;2.天津医科大学南开临床学院麻醉科,天津市南开医院麻醉科,天津300100)

Author(s):

XU De-fang¹; 2 ; YU Jian-bo²; MU Rong¹;  ZHANG Li ¹;  WANG Bing-shu ¹;  ZHOU Chun-jing ¹;  WANG Fang ¹

(1.Department of Anesthesiology，The Fourth Center Clinical College ，Tianjin Medical Univercity， The Fourth Center Hospital of Tianjin ，Tianjin 300140，Chian；2. Department of Anesthesiology，The Nan Kai Clinical College of Tianjin Medical Univercity, The Nan Kai Hospital of Tianjin,Tianjin 300100, China)

关键词:

丙泊酚; 七氟烷; 依托咪酯; 氧化应激; 体外循环

Keywords:

propoful; sevoflurane; etomidate; oxidative stress; cardiopulmonary bypass

分类号:

R614

DOI:

-

文献标志码:

A

摘要:

 目的：观察不同麻醉方式对体外循环冠状动脉搭桥术（CABG）患者围术期氧化应激反应的影响。方法：择期拟行体外循环下CABG术患者45例，随机分为3组(每组15例)：丙泊酚组（P组）、依托咪酯组（E组）和七氟烷组（S组）。分别于麻醉前、手术切皮时、体外循环开始前、手术结束时、术后6 、24 、48 、72　h（T_0～7）记录患者心率（HR）和平均动脉压（MAP），并于T₀、T_4～7时取血测定过氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）含量。结果：3组患者在T₅和T₆时点SOD、CAT和GSH-Px活性均低于术前（P<0.05）。S组在T₇ 时点SOD和GSH-Px活性依然低于术前（P<0.05）。E组和S组的SOD、CAT和GSH-Px活性在术后均不同程度低于P组（P<0.05）。与E组相比，S组SOD、 CAT和GSH-Px活性在术后有不同程度升高（P<0.05）。结论：与七氟烷和依托咪酯相比较，丙泊酚能更好地对抗体外循CABG术围术期的氧化应激反应。

Abstract:

 Objective：To observe effects of different anesthesia on perioperative oxidative stress in patients with coronary artery bypass grafting （CABG）operation. Methods： Forty five patients undergoing coronary artery bypass grafting operation with cardiopulmonary bypass were randomly divided into 3 groups(n=15)：propofol group (group P),etomidate group (group E) and sevoflurane group (group S). At the times before anesthesia, incision, and CPB, by the end of operation, 6,24,48,72 h after operation (T_0-7),heart rate (HR) and mean arterial pressure (MAP) were recorded. At T₀ and T₄ to T₇, the activity of superoxide dismutase (SOD) and catalase (CAT) were measured. Results：The activities of SOD,CAT and GSH-Px at T₅ and T₆ in 3 groups were lower than those at T₀（P <0.05）.The activities of SOD and GSH-Px at T₇ in group S were also lower than those at T₀ （P <0.05）. Compared with group E and group S ,the activities of SOD,CAT and GSH- Px were lower than group P in different degrees after the operation（P <0.05）. Compared with group E , the activities of SOD,CAT and GSH- Px in group S were significantly increased after the operation to various degrees（P <0.05）. Conclusion： Propofol may have better effect on oxidative stress of CABG.

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备注/Memo

备注/Memo:

作者简介 许德芳（1982-），女，住院医师，硕士在读，研究方向:临床麻醉；通信作者：余剑波,E-mail: jianboyu99@sina.com。

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更新日期/Last Update: 2015-07-17