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[1]李 慧,姜行康,齐士勇,等.前列腺穿刺标本中神经周围侵犯对根治术后患者预后的影响[J].天津医科大学学报,2015,21(03):233-235.
 LI Hui,JIANG Xing-kang,QI Shi-yong,et al.Perineural invasion in prostate biopsy specimen affect ing the prognosis of patients with radical prostatectomy [J].Journal of Tianjin Medical University,2015,21(03):233-235.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
233-235
栏目:
临床医学
出版日期:
2015-05-20

文章信息/Info

Title:
Perineural invasion in prostate biopsy specimen affect ing the prognosis of patients with radical prostatectomy
文章编号:
1006-8147(2015)03-0233-03
作者:
李 慧姜行康齐士勇杨宇明王 超陈晓博张晓会徐 勇
(天津医科大学第二医院泌尿外科,天津市泌尿外科研究所,天津 300211)
Author(s):
LI Hui JIANG Xing-kang QI Shi-yong YANG Yu-ming WANG Chao CHEN Xiao-bo ZHANG Xiao-hui XU Yong
(Department of Urology, The Second Hospital, Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, China)
关键词:

前列腺癌前列腺穿刺活检神经周围侵犯根治性前列腺切除术预后

Keywords:
prostate cancer prostate biopsy perineural invasion radical prostatectomy prognosis
分类号:
R737.25
DOI:
-
文献标志码:
A
摘要:

目的: 探讨前列腺穿刺活检标本中神经周围侵犯(PNI)对根治性前列腺切除术患者预后的影响。方法: 回顾性分析经耻骨后根治性前列腺切除术或腹腔镜根治性前列腺切除术的160例局限性前列腺癌患者的临床资料,所有患者术前均进行前列腺穿刺活检并进行常规石蜡切片后行苏木精-伊红染色,以肿瘤细胞浸润神经束或神经束膜判定为PNI阳性。分析标本中PNI与前列腺癌临床病理特征以及根治性前列腺切除术预后的关系。结果: 160例前列腺癌患者中PNI阳性27例(16.9%)。PNI与前列腺穿刺活检Gleason评分、前列腺癌临床分期、手术切缘阳性有关(P<0.05)。PNI阳性组患者在根治性前列腺切除术后无生化复发生存期为(75.79±6.38)个月,明显短于PNI阴性组的(88.46±2.41)个月(P<0.05)。PNI阳性组患者的总生存期为(84.32±2.96)月,而非PNI组总生存期为(94.50±2.38)个月(P<0.05)。结论: 前列腺穿刺标本中PNI可作为判断前列腺癌患者根治性前列腺切除术后不良预后的指标。

Abstract:
Objective To investigate the relationship between perineural invasion (PNI) in prostate biopsy and radical prostatectomy outcomes. Methods: One hundred and sixty patients undergoing radical prostatectomy were analyzed retrospectively. Paraffin sections of the specimens from all patients who underwent prostate biopsy were stained with HE. PNI-positive was defined as infiltration of carcinoma cell into the perineurium or neural fascia. The association of PNI with clinicopathologic features of prostate cancer and radical prostatectomy outcomes were analyzed. Results:PNI was positive in 16.9%(27/160) of the patients. The prostate biopsy Gleason score,clinical staging of prostate cancer,surgical margin were significantly associated with PNI (P<0.05). The biochemical-recurrence-free survival time of PNI-positive patients after radical prostatectomy was shorter than that of the PNI-negative patients [(75.79+6.38) months vs (88.46+2.41) months, P<0.05]. Furthermore, the overall survival time of PNI-positive patients was shorter than that of the PNI-negative [(84.32+2.96) months vs (94.50+2.38) months, P<0.05]. ConclusionPNI in prostate biopsy can be used as one of the indicators to predict adverse prostatectomy outcomes.

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备注/Memo

备注/Memo:
基金项目 天津市应用基础及前沿技术研究计划资金资助(12JCYBJC31400)
作者简介 李慧(1985-),男,硕士在读,研究方向:泌尿外科学;通信作者:徐勇,E-mail: xuyong8816@sina.com
更新日期/Last Update: 2015-05-27