|本期目录/Table of Contents|

[1]王伟占,孙立亭,赵志强,等.胰岛素抵抗OLETF大鼠血清IL-18水平变化及替米沙坦的干预研究[J].天津医科大学学报,2015,21(02):101-104.
 WANG Wei-zhan,SUN Li-ting,ZHAO Zhi-qiang,et al.Change of interleukin-18 in OLETF rats with insulin resistance and effects of telmisartan[J].Journal of Tianjin Medical University,2015,21(02):101-104.
点击复制

胰岛素抵抗OLETF大鼠血清IL-18水平变化及替米沙坦的干预研究(PDF)
分享到:

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年02期
页码:
101-104
栏目:
基础医学
出版日期:
2015-03-20

文章信息/Info

Title:
Change of interleukin-18 in OLETF rats with insulin resistance and effects of telmisartan
文章编号:
1006-8147(2015)02-0101-04
作者:
王伟占14孙立亭1赵志强2 田凤石3
(1.天津医科大学研究生院,天津 300070;2.天津医科大学第二医院心内科, 天津 300211;3.天津市第四中心医院心内科,天津 300140;天津医科大学第四中心临床学院心内科,天津 300140)
Author(s):
WANG Wei-zhan14 SUN Li-ting1 ZHAO Zhi-qiang2 TIAN Feng-shi3
(1.Graduate  School,Tianjin Medical University, Tianjin 300070 China; 2. Department of Cardiology, The Second Hospital, Tianjin Medical University ,Tianjin 300211 China,;3. Department of Cardiology ,The Fourth Center Hospital of Tianjin , Tianjin 300140 China ;4.Department of Cardiology,The Fourth Center Clinical College,Tianjin Medical University ,Tianjin  300140 China )
关键词:
胰岛素抵抗替米沙坦OLETF大鼠白介素-18
Keywords:
insulin resistance telmisartan OLETF rats IL-18
分类号:
R589
DOI:
-
文献标志码:
A
摘要:
目的:测定胰岛素抵抗(IR)OLETF大鼠血清白介素-18(IL-18)的表达水平,研究血管紧张素Ⅱ 1型受体拮抗剂 (AT1R) 替米沙坦对IL-18水平的影响及对IR的干预作用,探讨其改善IR的可能机制。方法:OLETF大鼠24只,高脂喂养20周诱导建立IR模型,将成功造模的24只IR大鼠随机分为2组,模型(M)组12只继续给予高脂饲料,替米沙坦(T)组12只给予替米沙坦(5 mg/kg﹒d)加高脂饲料,LETO大鼠12只为对照(NC)组,给予标准饲料。干预20周后测定两组大鼠的体质量(W)、血清胰岛素(FINS)、空腹血糖(FBG)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及IL-18水平,并计算胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)。 结果:M组大鼠与NC组大鼠相比,W、FBG、TG、LDL-C及IL-18水平明显增高(P<0.05或P <0.01) ;T组与M组相比,FBG、TG、LDL-C、IL-18水平明显降低(P<0.05或P <0.01) 。多元线性回归分析提示IL-18是HOMA-IR的独立影响因素。 结论:IL-18可能通过促进炎症参与了IR,而替米沙坦可能通过调节糖脂代谢、抑制前炎性因子IL-18的表达改善IR。
Abstract:
Objective: To investigate change of interleukin-18 (IL-18) in OLETF rats with insulin resistance, and to study the effect of angiotensin II type 1 receptor antagonists (AT1R) telmisartan on insulin resistance and the expression of IL-18, and the possible mechanisms of telmisartan improving IR. Methods: Twenty-four OLETF rats were fed with high-fat diet for 20 weeks to establish the insulin resistance model. Twenty-four OLETF rats with insulin resistance were randomly assigned into two groups: the model group (group M), in which the rats were fed with high-fat diet; the telmisartan group (group T), in which the rats were fed with high-fat diet and telmisartan(5 mg/kg﹒d). Twelve LETO rats fed with normal diet served as normal control group (group NC). After 20 weeks of drug intervention, the weight(W),plasma levels of fasting insulin (FINS), fasting blood glucose(FBG), triglycerides(TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and interleukin-18 (IL-18) were detected in two groups. And HOMA-IR and ISI were measured. Results: Compared with group NC, the W,FBG,TG,LDL-C and IL-18 were significantly increased in group M(P <0.05 or P <0.01); compared with group M, the FBG,TG,LDL-C and IL-18 were significantly decreased in group T(P <0.05 or P <0.01) . The multiple linear regression analysis showed that the serum IL-18 was an independent determinant of HOMA-IR. Conclusion: The IL-18 is an independent factor for IR, and telmisartan can improve insulin resistance by regulating blood glucose and serum lipid as well as inhibiting the expression of IL-18 .

参考文献/References:

[1]田雨,麦劲壮,李莹,等. 代谢综合征与心脑血管病关系的前瞻性研究[J]. 中国预防医学杂志, 2013,14(4):241

[2]戴晓岚. 代谢综合征的研究新进展[J]. 中国慢性病预防与控制, 2011,19(4):432

[3]Rabkin S W, Langer A, Ur E, et al. Inflammatory biomarkers CRP, MCP-1, serum amyloid alpha and interleukin-18 in patients with HTN and dyslipidemia: impact of diabetes mellitus on metabolic syndrome and the effect of statin therapy[J]. Hypertens Res, 2013,36(6):550

[4]Presta I, Andreozzi F, Succurro E. IL-18 gene polymorphism and metabolic syndrome[J]. Nutr Metab Cardiovasc Dis, 2009,19(2):5

[5]Yamaoka-Tojo M, TaikiTojo, Kazuki W, et al. Circulating intetleukin-18:A specific biomarker for atherosclerosis-prone patients with metabolic syndrome[J]. Nutr Metab (Lond), 2011,8(3):1

[6]郑喜兰,姚瑞栋,田凤石,等. 替米沙坦对早期喂养高脂OLETF大鼠MS相关因素的影响[J]. 中国现代医学杂志, 2011,21(14):1577

[7]Chen B H, Song Y, Ding E L, et al. Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts[J]. Diabetes Care, 2009,32(2):329

[8]郁秀琴,陈双,古丽扎尔·买买提明. 抵抗素、CRP、IL-18和白细胞与代谢综合征关系的探讨[J]. 中华全科医学, 2012,10(2):193

[9]赵星,方洁. 不同糖耐量人群血浆IL-18水平与胰岛素抵抗的相关性[J]. 贵阳医学院学报, 2009,34(4):399

[10]Stensvold D, Slørdahl S A, Wisløff U. Effect of exercise training on inflammation status among People with metabolic syndrome[J]. Metab Syndr Relat Disord, 2012,10(4):267

[11]Hung J, Mcquillan B M, Chapman C M, et al. Elevated interleukin-18 levels are associated with the metabolic syndrome Independent of obesity and insulin resistance[J]. Arterioscler Thromb Vasc Biol, 2005,25(6):1268

[12]Ushijima K, Takuma M, Ando H, et al. Effect of telmisartan and valsartan on insulin sensitivity in obese diabetic mice[J]. Eur J Pharmacol, 2013,698(1/3):505

相似文献/References:

[1]张 建,张明谏,刘 曼,等.非诺贝特改善严重烫伤小鼠应激状态下胰岛素抵抗作用的效果观察[J].天津医科大学学报,2013,19(06):441.
 ZHANG Jian,ZHANG Ming-jian,LIU Man,et al.Effects of fenofibrate on insulin resistance in severely scalded mice[J].Journal of Tianjin Medical University,2013,19(02):441.
[2]马晓芳,童静凯,牛文彦.肥胖和缺氧对小鼠原代脂肪细胞分泌TNFα的影响[J].天津医科大学学报,2014,20(01):1.
 MA Xiao-fang,TONG Jing-kai,NIU Wen-yan.Effect of obesity and hypoxia on TNFa secretion by primary adipocytes in mice[J].Journal of Tianjin Medical University,2014,20(02):1.
[3]周晓磊,张 鹏 综述,尤胜义 审校.核因子-κB信号途径与胰岛素抵抗关系的研究进展[J].天津医科大学学报,2014,20(01):77.
[4]杨传慧,李 萍,何 庆,等.不同时间持续缺氧对3T3-L1脂肪细胞脂肪因子基因表达的影响[J].天津医科大学学报,2015,21(03):1.
 YANG Chuan-hui,LI Ping,HE Qing,et al.Effect of incubation time of hypoxia on the levels of adipokines in the 3T3-L1 adipocytes[J].Journal of Tianjin Medical University,2015,21(02):1.
[5]杨传慧,李 萍,何 庆,等.不同时间持续缺氧对3T3-L1脂肪细胞脂肪因子基因表达的影响[J].天津医科大学学报,2015,21(01):1.
 YANG Chuan-hui,LI Ping,HE Qing,et al. Effect of incubation time of hypoxia on the expression of adipokines in the 3T3-L1 adipocytes[J].Journal of Tianjin Medical University,2015,21(02):1.
[6]赵一贺,张 畅,牛文彦.电脉冲刺激的骨骼肌细胞条件培养基逆转内皮细胞胰岛素抵抗和功能障碍[J].天津医科大学学报,2017,23(01):1.
 ZHAO Yi-he,ZHANG Chang,NIU Wen-yan.Conditional medium from electric pulse-stimulated C2C12 skeletal muscle cells reverses insulin resistance and endothelial dysfunction in endothelial cells[J].Journal of Tianjin Medical University,2017,23(02):1.
[7]卢姿瑾,王 伟.急性心肌梗死患者胰岛素抵抗与冠状动脉病变关系的初步研究[J].天津医科大学学报,2017,23(02):161.
 LU Zi-jin,WANG Wei.Relationship of insulin resistance and coronary artery disease in patients with acute myocardial infarction[J].Journal of Tianjin Medical University,2017,23(02):161.
[8]胡 楠,刘 艳,李素芬,等.不同体质指数儿童青少年瘦素、脂联素、FGF-21与胰岛素抵抗的相关性分析[J].天津医科大学学报,2017,23(05):419.
 HU Nan,LIU Yan,LI Su-fen,et al.Relations of IR to LEP, APN and FGF-21 among children with different BMIs[J].Journal of Tianjin Medical University,2017,23(02):419.
[9]李英,张学军.miR-93在多囊卵巢综合征患者血清中的表达及临床意义[J].天津医科大学学报,2018,24(03):209.
 LI Ying,ZHANG Xue-jun.Expression and clinical significance of miR-93 in the serum of patients with polycystic ovary syndrome[J].Journal of Tianjin Medical University,2018,24(02):209.
[10]李瀚琪,牛文彦.iNOS调节Rab8参与肥胖诱导的胰岛素抵抗[J].天津医科大学学报,2019,25(03):201.
 LI Han-qi,NIU Wen-yan.iNOS participates in obesity-induced insulin resistance by regulating Rab8[J].Journal of Tianjin Medical University,2019,25(02):201.
[11]任梦萌,王伟占,方 涛,等.替米沙坦对胰岛素抵抗大鼠PPAR-?蛋白表达的影响[J].天津医科大学学报,2017,23(02):124.
 REN Meng-meng,WANG Wei-zhan,FANG Tao,et al.Effects of telmisartan on the expression of PPAR-? protein in OLETF rats with insulin resistance[J].Journal of Tianjin Medical University,2017,23(02):124.

备注/Memo

备注/Memo:
作者简介 王伟占(1987-),女,硕士在读,研究方向:心血管内科;

通信作者:田凤石,E-mail:fengshitian080101@.126.com。

更新日期/Last Update: 2015-03-24