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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

20卷

期数:

2014年05期

页码:

389-391

栏目:

临床医学

出版日期:

2014-09-20

文章信息/Info

Title:

Relationship between thyroid stimulating hormone and urinary calcium/creatinine excretion in middle-aged man with type 2 diabetes

文章编号:

1006-8147(2014)05-0389-03

作者:

李凤英¹ ; 朱铁虹²

(1.天津医科大学研究生院,天津300070;2.天津医科大学总医院内分泌科,天津300052)

Author(s):

LI Feng-ying¹; ZHU Tie-hong²

(1.Graduate School, Tianjin Medical University, Tianjin 300070，China; 2.Department of Endocrinology, General Hospital, Tianjin Medical University, Tianjin 300052，China)

关键词:

促甲状腺激素; 尿钙/肌酐比值; 糖尿病; 2型

Keywords:

thyroid stimulating hormone ;  urinary calcium/creatinine excretion ;  diabetes mellitus ; type 2

分类号:

R587.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨中年男性2型糖尿病患者促甲状腺激素与尿钙/肌酐比值的相关性。方法：根据血促甲状腺激素（TSH）水平将516例中年男性2型糖尿病患者分为低TSH组、正常TSH组和高TSH组，测量身高、体质量、血压、空腹血糖、血肌酐、碱性磷酸酶、血钙、血磷、TSH、24 h尿钙、尿磷、尿肌酐。结果：随着TSH水平升高，中年男性2型糖尿病患者尿钙及尿钙/肌酐比值逐步降低（均P趋势＜0.05）。多元线性回归分析经年龄、糖尿病病程等因素调整后仍显示TSH是影响尿钙/肌酐比值的相关因素（β=-0.024，P＜0.05）。结论：中年男性2型糖尿病患者TSH与尿钙/肌酐比值呈负相关，TSH是影响尿钙排泄率的独立影响因素。

Abstract:

Objective: To investigate the relationship between thyroid stimulating hormone (TSH) and urinary calcium/creatinine excretion in middle-aged man with type 2 diabetes. Methods: Five hundred and sixteen middle-aged man with type 2 diabetes were included in the study. Based on their TSH, these subjects were divided into three groups : low TSH group , normal TSH group and high TSH group . Height，weight，blood pressure，fasting blood glucose，serum creatinine，alkaline phosphatase，serum calcium，serum phosphorus，TSH，24h urinary calcium，urinary phosphorus，urinary creatinine were measured. Results： A relationship of lower calcium and lower urinary calcium/creatinine excretion with increasing TSH, even after adjusting age and diabetic duration, was found ( both Ptrend ＜0.05). Multiple linear regression analysis showed that TSH could be associated with urinary calcium/creatinine excretion (β=-0.024，P＜0.05). Conclusion: TSH has a negative correlation with urinary calcium/creatinine excretion in middle-aged man with type 2 diabetes, and can function as an independent acting factor of urinary calcium excretion rate。

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 李凤英（1968-），女，硕士在读，研究方向：内分泌与代谢病；通信作者：朱铁虹，E-mail:zhutiehong@163.com。

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更新日期/Last Update: 2014-09-25