|本期目录/Table of Contents|

[1]李晓洁,周 蕾,陈 宪,等.超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系[J].天津医科大学学报,2015,21(03):63-64.
 LI Xiao-jie,ZHOU Lei,CHEN Xian,et al.Relationship between high-sensitivity C-reactive and complement 3 and disease activity in systemic lupus erythematosus[J].Journal of Tianjin Medical University,2015,21(03):63-64.
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超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年03期
页码:
63-64
栏目:
临床医学
出版日期:
2015-05-20

文章信息/Info

Title:
Relationship between  high-sensitivity C-reactive and complement 3 and disease activity in systemic lupus erythematosus
文章编号:
1006-8147(2015)01-0063-02
作者:
李晓洁周 蕾陈 宪王颖嫒
(天津医科大学总医院风湿免疫科 ,天津 300052)
Author(s):
LI Xiao-jie ZHOU Lei CHEN Xian WANG Ying-ai
(Department of Rheumatology and Immunology ,Tianjin Medical University ,General Hospital ,Tianjin 300052 ,China)
关键词:
红斑狼疮系统性超敏C反应蛋白补体C3疾病活动度
Keywords:
lupus erythematosussystemichigh-sensitivity C-reactive protein complement 3disease activity
分类号:
R593.24+1
DOI:
-
文献标志码:
A
摘要:
 目的 :探讨超敏C反应蛋白(hsCRP)和补体C3与系统性红斑狼疮(SLE)疾病活动度间的关系。方法 选取SLE患者101例,根据SLE疾病活动性指数(SLEDAI)评分分为缓解组(n=73)和活动组(n=28),应用免疫透射比浊法检测101例患者血浆hsCRP,应用速率放射比浊法检测患者血清C3,分组比较上述指标及其与疾病活动度的相关性。采用独立样本t检验、 X2检验和Pearson相关分析进行统计学分析。结果 : 活动组SLE患者hsCRP水平高于缓解组[(9.03±6.84)mg/L] vs [(1.51±1.27)mg/L] ,活动组SLE患者补体C3水平低于缓解组[(677.00±389.75)mg/L]vs[(877.94±316.54)mg/L],分别比较差异有统计学意义(P<0.05);hsCRP水平与SLEDAI评分呈正相关(r=0.649,P<0.01),补体C3水平与SLEDAI评分呈负相关(r=-0.590,P<0.01)。结论 : HsCRP和补体C3水平与SLE疾病活动密切相关,可作为SLE患者疾病活动度监测和治疗效果的评估指标。
Abstract:
Objective : To explore the relationship between the levels of high-sensitivity C-reactive protein(hsCRP),complement3(C3) and disease activity in patients with systemic lupus erythematosus(SLE).Methods A total of 101 patients with SLEwere divided into two groups in accordance with SLEDAI scores, the active group(n=28)and the remission group(n=73).Plasma was assayed for hsCRP by immunological transmission turbidimetry,and serum was assayed for C3 by radiation rate nephelometry. All data were analyzed by Students’t test, Chi-squared test and Pearson regression analysis.ResultsPatients in active group had higher hsCRP levels than patients in remisson group[(9.03±6.84)mg/L ] vs [(1.51±1.27)mg/L],and patients in active group had lower C3 levels than patients in remisson group[(677.00±389.75)mg/L] vs[(877.94±316.54)mg/L] differences were statistically significant(P<0.05);hsCRP levels were positively correlated with SLEDAI score(r=0.649,P<0.01),complement3 levels and SLEDAI score were negatively correlated(r=-0.590,P<0.01).Conclusion : HsCRP and C3 are closely related with SLE activity and can be used as one of the indicators for SLE activity and the clinical result.

参考文献/References:

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[5]张晓慧,李光韬,张卓莉. C反应蛋白与超敏C反应蛋白的检测及其临床意义[J]. 中华临床免疫和变态反应杂志, 2011,5(1):74

[6]周明莉,蔡爱玲,王雪峰. 降钙素原及C反应蛋白测定在新生儿感染性疾病诊断中的应用[J]. 国际检验医学杂志, 2011,32(6):683

[7]Wadhwa A, Avasthi R, Ghambhir J K, et al. To study the prevalence and profile of metabolic syndrome,levels of hs-CRP,Lp(a)and serum ferritin in young Indian patients(<or=45 years)with acute myocardial infarction[J]. J Assoc Physicians India, 2013,61(6):384

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备注/Memo

备注/Memo:
 作者简介 李晓洁(1989-),女,硕士在读,研究方向:风湿病学;通信作者:周蕾,E-mail:yizhe1234@126.com
更新日期/Last Update: 2015-01-22