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[1]季艳会,谭 建,王任飞.99Tcm-MIBI及131I全身显像在分化型甲状腺癌病灶探测中的应用[J].天津医科大学学报,2014,20(06):459-463.
　JI Yan-hui,TAN Jian,WANG Ren-fei.Application of 99Tcm-MIBI whole body scanningand post-therapeutic 131I whole body scanningin the detection of lesions in differentiated thyroid cancer[J].Journal of Tianjin Medical University,2014,20(06):459-463.
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99Tcm-MIBI及131I全身显像在分化型甲状腺癌病灶探测中的应用(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年06期
页码:
459-463
栏目:
临床医学
出版日期:
2014-11-20

文章信息/Info

Title:
Application of 99Tcm-MIBI whole body scanningand post-therapeutic 131I whole body scanningin the detection of lesions in differentiated thyroid cancer
文章编号:
1006-8147（2014）06-0459-05
作者:
季艳会; 谭 建; 王任飞
(天津医科大学总医院核医学科,天津 300052)
Author(s):
JI Yan-hui;  TAN Jian;  WANG Ren-fei
(Department of Nuclear Medicine, General Hospital, Tianjin Medical University, Tianjin 300052,China)
关键词:
分化型甲状腺癌;  131I全身扫描; 99Tcm-MIBI全身扫描; 甲状腺球蛋白
Keywords:
differentiated thyroid carcinoma;  131 I whole body scan;  99Tcm-MIBI whole body scan;  thyroglobulin
分类号:
R736.1+R730.44
DOI:
-
文献标志码:
A
摘要:
目的：探讨131I全身扫描(131I-WBS)、99Tcm-MIBI全身扫描(99Tcm-MIBI-WBS)及Tg监测对分化型甲状腺癌（DTC）复发或转移灶检测的临床价值。方法：回顾142例131I 治疗DTC患者影像学资料，分析该病131I-WBS及99Tcm-MIBI-WBS影像学特征及临床价值，并分析实验室血清测定结果。结果：131I-WBS对DTC转移灶的敏感度为85.1%，特异度为84.2%，阳性预测率为72.7%，阴性预测率为92%；99Tcm-MIBI-WBS对DTC转移灶的敏感度为80%，特异度为95.5%，阳性预测率为88.9%，阴性预测率为91.3%。两项检查联合对DTC转移灶的敏感度为100%，特异度为86.4%，阳性预测率为76.9%，阴性预测率为100%。血清甲状腺球蛋白(Tg)水平测定对判定DTC是否存在转移灶具有指示意义。结论：131I-WBS与99Tcm-MIBI-WBS联合应用可以弥补单一种类显像的不足，提高转移灶的检出率。血清Tg测定结果可以用于评价DTC术后患者是否存在转移灶。
Abstract:

Objective: To explore features of 131I-WBS and 99Tcm-MIBI-WBS of the post- therapeutic differentiated thyroid carcinoma（DTC）, and to discover the relationship between the results of the laboratory tests and DTC metastases for early detection of clinical of DTC metastases. Methods: 131I-WBS of 142 cases receiving more than two 131I therapies and 99Tcm-MIBI-WBS of 32 cases were analyzed. Features of 131I-WBS and 99mTc-MIBI-WBS and results of laboratory serum determinations were summarized. Results: The sensitivity of detection for 131I-WBS was 85.1%, for 99Tcm-MIBI-WBS 80%, and for combined imaging 100%. The specificity for 131I-WBS was 84.2%, for 99Tcm-MIBI-WBS 95.5%, and for combined imaging 86.4%. The positive predictive value (PPV) for 131I-WBS was 72.7%, for 99Tcm-MIBI-WBS 88.9%, and for combined imaging 76.9%. The negative predictive value (NPV) for 131I-WBS was 92%, for 99mTc-MIBI-WBS 91.3%, and for combined imaging 100%. Serum Tg determinations can be used to diagnose DTC metastases. Conclusion: Combined 131I-WBS and 99Tcm-MIBI-WBS are superior to any mono-imaging method, and it can enhance the diagnosis rate of DTC metastases. Results of serum Tg determination could evaluate DTC metastase conditions, which may influence the result of 131I-WBS.

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备注/Memo

备注/Memo:

作者简介 季艳会（1988-），女，硕士在读，研究方向：影像医学与核医学;

通信作者：谭建，E-mail：tanpost@163.cm。

更新日期/Last Update: 2014-12-02