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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

30卷

期数:

2024年01期

页码:

74-78

栏目:

临床医学

出版日期:

2024-01-01

文章信息/Info

Title:

Clinical evaluation of peripheral blood cells， derived parameters， and coagulation function in adenomyosis patients

文章编号:

1006-8147(2024)01-0074-05

作者:

桑佳特; 杜 雪

（天津市人民医院妇科，天津300121）

Author(s):

SANG Jiate;  DU Xue

（Department of Gynecology，Tianjin Union Medical Center，Tianjin 300121，China ）

关键词:

子宫腺肌病; 凝血功能; CA125; 子宫体积; 贫血

Keywords:

adenomyosis; coagulation function; CA125; uterine volume; anemia

分类号:

R71

DOI:

10.20135/j.issn.1006-8147.2024.01.0074

文献标志码:

A

摘要:

目的：初步探讨子宫腺肌病患者外周血血细胞及其衍生参数和凝血功能的改变， 研究其对子宫腺肌病的临床意义和诊断价值。方法：回顾性分析2018年9月—2023年8月于天津市人民医院妇科住院治疗的子宫腺肌病患者（除外子宫肌瘤和子宫内膜异位症）26例。将同期良性卵巢囊肿或子宫内膜单纯性增生的患者（33例）作为对照组，比较两组的临床资料、外周血血细胞、系统性免疫性炎症指数（SII）、全系统性炎症反应指数（SIRI）、凝血功能及血清糖类抗原125（CA125）水平，分析其在子宫腺肌病中的临床意义。结果：与对照组相比，子宫腺肌病组子宫体积增大（Z=-5.746，P<0.01）， PLR、 SII、 CA125水平升高（Z=-2.351、 -3.810、-4.805，均P<0.01）。凝血功能方面，凝血酶时间在子宫腺肌病组中明显缩短（Z=-1.971，P<0.05）。子宫腺肌病非出血期组与对照组非出血组间的纤维蛋白原差异具有统计学意义（Z=-1.969，P<0.05）。子宫腺肌病非出血贫血组与对照组非出血贫血组相比，活化部分凝血酶原时间延长（Z=-2.200，P<0.05）。相关性分析发现，子宫腺肌病血红蛋白与凝血酶时间呈正相关（r=0.466，P=0.016）。绘制受试者工作特征曲线后，CA125、PLR和SII的曲线下面积分别为0.883、0.665、0.644。结论：子宫腺肌病患者存在凝血功能异常，CA125对子宫腺肌病有较高的诊断价值，PLR、SII对子宫腺肌病的诊断也有一定的准确性。

Abstract:

Objective： To explore the changes in peripheral blood cells， derived parameters， and coagulation function in adeno-myosis patients， and to investigate their clinical significance and diagnostic value for adenomyosis. Methods： A total of 26 patients with adenomyosis（excluding uterine fibroids and endometriosis） who were hospitalized in the Department of Gynecology of Tianjin Union Medical Center from September 2018 to August 2023 were retrospectively conducted. A total of 33 patients with benign ovarian cysts or simple endometrial hyperplasia during the same period were selected as the control group. The clinical data， peripheral blood cells， systemic immune inflammatory index（SII）， systemic inflammatory response index（SIRI）， coagulation function， and serum carbohydrate antigen 125（CA125） levels were compared between the two groups， and their clinical significance in adenomyosis was analyzed. Results： Compared with the control group， the uterine volume in the adenomyosis group increased （Z=-5.746， P<0.01）， and the levels of PLR， SII， and CA125 increased （Z=-2.351， -3.810， -4.805， all P<0.01）. In terms of coagulation function， thrombin time was significantly shortened in the adenomyosis group（Z=-1.971， P<0.05）. There was a statistically significant difference in fibrinogen between the non-bleeding stage group of adenomyosis and the control group（Z=-1.969， P<0.05）. Compared with the control group， the non-bleeding anemia group with adenomyosis of the uterus showed a longer activated partial prothrombin time（Z=-2.200， P<0.05）. Correlation analysis found a positive correlation between hemoglobin and thrombin time in adenomyosis（r=0.466， P=0.016）. After drawing the receiver operating characteristic curves of the subjects， the areas under the curves for CA125， PLR， and SII were 0.883， 0.665， and 0.644， respectively. Conclusion： Patients with adenomyosis have abnormal coagulation function， and CA125 has a high diagnostic value for adenomyosis. PLR and SII also have certain accuracy in the diagnosis of adenomyosis.

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相似文献/References:

备注/Memo

备注/Memo:

作者简介 桑佳特（1987-），女，医师，硕士，研究方向：子宫肌腺病的临床与基础；通信作者：杜雪，E-mail：lanlandetommao@163.com。

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更新日期/Last Update: 2024-01-01