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[1]范宏光,梁雪梅,李强,等.Theta爆发式经颅磁刺激治疗偏头痛的盲法对照研究[J].天津医科大学学报,2023,29(06):628-631.
　FAN Hong-guang,LIANG Xue-mei,LI Qiang,et al.Theta burst stimulation in the treatment of migraine：a double-blind，controlled clinical trial[J].Journal of Tianjin Medical University,2023,29(06):628-631.
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Theta爆发式经颅磁刺激治疗偏头痛的盲法对照研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
29卷
期数:
2023年06期
页码:
628-631
栏目:
临床医学
出版日期:
2023-11-20

文章信息/Info

Title:
Theta burst stimulation in the treatment of migraine：a double-blind，controlled clinical trial
文章编号:
1006-8147(2023) 06-0628-04
作者:
范宏光; 梁雪梅; 李强; 谷亚伟; 董银华; 王利军
（天津医科大学第四中心临床学院神经内科，天津 300140）
Author(s):
FAN Hong-guang; LIANG Xue-mei; LI Qiang; GU Ya-wei; DONG Yin-hua; WANG Li-jun
（Department of Neurology，The Fourth Clinical Hospital of Tianjin Medical University，Tianjin 300140，China）
关键词:
Theta爆发式经颅磁刺激; 偏头痛; 治疗
Keywords:
theta burst stimulation;  treatment;  migraine
分类号:
R74
DOI:
-
文献标志码:
A
摘要:
目的：通过盲法对照研究观察Theta爆发式经颅磁刺激（TBS）治疗偏头痛的疗效和不良反应。方法：采用SPSS19.0软件生成随机数，将2021年3月—2022年10月就诊的120例偏头痛患者分成TBS组和伪刺激组，每组60例，TBS组采用TBS治疗，伪刺激组则翻转刺激磁头给予伪刺激方法，观察周期为两周，每周干预5次。于治疗前、治疗后和治疗结束后第4周末分别记录头痛发作频率、头痛持续时间、视觉模拟疼痛（VAS）评分及不良反应等观察指标，并加以统计分析。结果：治疗前两组患者的发作频率、持续时间及VAS评分比较，差异无统计学意义（均P＞0.05）；治疗后，TBS组偏头痛的发作频率（t=9.811）、持续时间（t=8.329）、VAS评分（t=1.147）均显著低于伪刺激组（均P＜0.05）。治疗结束后第4周末，TBS组患者偏头痛的发作频率（t=9.875）、持续时间（t=12.810）、VAS评分（t=12.439）均显著低于伪刺激组 （均P＜0.05）。TBS组疗效显著高于伪刺激组（?字2=7.810，P＜0.05）；而不良反应与伪刺激组无统计学差异（P＞0.05）。结论：TBS治疗偏头痛安全、有效。
Abstract:
Objective： To observe the efficacy and adverse reactions of theta burst stimulation（TBS） on patient with migraine through a blind controlled study. Method：Using SPSS19.0 software to generate random numbers，a total of 120 patients with migraine who visited our hospital from March 2021 to October 2022 were divided into a TBS group and a pseudo stimulation group，with 60 patients in each group. TBS group of patients were treated by TBS，whereas sham stimulation group of patients received sham stimulation treatment by flipping the magnetic head. All patients were treated five times per week for 2 weeks. The researchers recorded observation indexes of patients，such as frequency and duration of headache，visual analog pain score （VAS） and adverse reactions，in the before and after treatment and at the 4th weekend after treatment，respectively. Results：There were no statistically significant difference in frequency，duration and VAS score in two groups of patients before treatment （all P>0.05）. After treatment，the frequency（t=9.811），duration（t=8.329） and VAS scores（t=1.147） of migraine in the TBS group of patients were significantly lower than the sham control group（all P<0.05）. At the 4th weekend after treatment frequency（t=9.875），duration（t=12.810） and VAS scores（t=12.439） in patients of TBS group were significantly lower than those in patients of the sham control group（all P<0.05）. On the whole，the clinical effect of TBS for migraine was significantly better than sham stimulation treatment （?字2=7.810，P<0.05）. But there was no statistically significant difference on the adverse reaction between the two groups of patients （P>0.05）. Conclusion：TBS is safe and effective treatment on migraine.

参考文献/References:

[1] SENG E K，ROBBINS M S，NICHOLSON R A. Acute migraine medication adherence，migraine disability and patient satisfaction：a naturalistic daily diary study[J]. Cephalalgia，2017，37（10）：955-964.
[2] COPPOLA G，DI LORENZO C，SERRAO M. et al. Pathophysiological targets for non-pharmacological treatment of migraine[J]. Cephalalgia，2016，36（12）：1103-1111.
[3] CAMERON C，KELLY S，HSIEH SC，et al. Triptans in the acute treatment of migraine：a systematic review and network meta-analysis[J]. Headache，2015，55（Suppl 4）：221-235.
[4] SAHU AK，SINHA VK，GOYAL N. Effect of adjunctive intermittent theta-burst repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine patients：a double-blind sham-controlled study[J].Indian J Psychiatry，2019，61（2）：139-145.
[5] 头面痛学组.中国偏头痛诊断治疗指南[J].中国疼痛医学杂志，2011，17（2）：65-86.
[6] 覃燕玲.氟桂利嗪单用及联用血塞通治疗老年偏头痛患者的疗效比较研究[J].现代诊断与治疗，2015，26（22）：5093-5095.
[7] 曹丽翠，王磊，贾红云，等.苯甲酸利扎曲普坦联合针灸治疗急性发作期偏头痛61例[J].中国老年学杂志，2015，35（10）：2766-2767.
[8] GAERTNER M，KONG J T，SCHERRER K H，et al. Advancing transcranial magnetic stimulation methods for complex regional pain syndrome：an open-label study of paired theta burst and high-frequency stimulation[J]. Neuromodulation，2018，21（4）：409-416.
[9] 闫国平，王小霞，徐晴，等.穴位热痛刺激治疗无先兆偏头痛患者的即时镇痛疗效观察[J].中华物理医学与康复杂志，2016，38（10）：760-763.
[10] HSU J H，DASKALAKIS Z J，BLUMBERGER D M. An update on repetitive transcranial magnetic stimulation for the treatment of co-morbid pain and depressive symptoms[J]. Curr Pain Headache Rep，2018，22（7）：51-56.
[11] CHUNG S W，HILL A T，ROGASCH N C，et al. Use of theta-burst stimulation in changing excitability of motor cortex：a systematic review and meta-analysis[J]. Neurosci Biobehav Rev，2016，63：43-64.
[12] POWERS S W，COFFEY C S，CHAMBERLIN L A，et al.Trial of amitriptyline，topiramate，and placebo for pediatric migraine[J]. N Engl J Med，2017，376（2）：115-124.

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备注/Memo

备注/Memo:
基金项目 天津市卫生健康科技项目（ZC20073）
作者简介 范宏光（1982-），男，副主任医师，硕士，研究方向：神经病学；通信作者：王利军，E-mail：wlj2004497@163.com。
更新日期/Last Update: 2023-12-01