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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

29卷

期数:

2023年03期

页码:

288-294

栏目:

临床医学

出版日期:

2023-05-20

文章信息/Info

Title:

Alpha rhythm asymmetry of spontaneous EEG signals in Parkinson′s disease patients with depression

文章编号:

1006－8147（2023）03-0288-07

作者:

刘玲凤¹; 张贝贝²; 王曙光²; 杨倩¹; 张莹²; 姜楠³; 张美云²

（1.天津医科大学人民医院临床学院，天津 300070；2.天津市人民医院神经内科，天津 300121；3.天津大学机械工程学院，天津 300354）

Author(s):

LIU Ling-feng¹; ZHANG Bei-bei²; WANG Shu-guang²; YANG Qian¹; ZHANG Ying²; JIANG Nan³; ZHANG Mei-yun²

（1.People′s Hospital Clinical School，Tianjin Medical University，Tianjin 300070，China；2.Department of Neurology，Tianjin Union Medical Center，Tianjin 300121，China；3.School of Mechanical Engineering，Tianjin University，Tianjin 300354，China）

关键词:

帕金森病; 抑郁; 脑电图; 半球不对称

Keywords:

Parkinson′s disease; depression; electroencephalogram; hemispheric asymmetry

分类号:

R741.044

DOI:

-

文献标志码:

A

摘要:

目的：研究帕金森伴抑郁患者清醒安静闭目状态下自发脑电信号α节律的半球不对称性及其与抑郁评分的关系。方法：采用子波变换的方法对23例帕金森伴发抑郁（dPD）患者和45例帕金森不伴抑郁（ndPD）患者的自发脑电信号进行定量分析，观察α节律的不对称性，用左右对应导联之间α频带相对功率的差值表示。比较dPD组和ndPD组之间α节律不对称性的差异；对α节律不对称性程度与抑郁量表评分行相关分析。结果：本研究68例帕金森患者中，抑郁发生率为33.82%。dPD组和ndPD组之间顶、枕区α节律不对称性有统计学差异（顶区：U=361.5，P=0.043；枕区U=329.5，P=0.015）；帕金森患者顶、枕区左右脑α相对功率值之差分别与抑郁评分呈正相关（ρ=0.307，P＜0.05；ρ=0.253，P＜0.05）。结论：大脑顶、枕区双侧半球之间α节律不对称性有助于区分帕金森伴或者不伴抑郁，并且这些α节律不对称程度均与抑郁评分相关，因此顶、枕区α节律不对称性有可能成为帕金森伴发抑郁的电生理标志物。

Abstract:

Objective： To investigate the hemispheric asymmetry of the alpha rhythm of spontaneous electroencephalogram（EEG） signals and its relationship to the depression score in Parkinson′s disease patients with depression in the awake，quiet and closed-eye state.Methods：Sub-wave transform method was used to quantitatively analyze the spontaneous EEG signals of 23 Parkinson′s disease patients with depression（dPD） and 45 Parkinson′s disease patients without depressed（ndPD）. The asymmetry of alpha rhythm was observed which was usually expressed as the difference of the relative power of alpha band between the left and right corresponding leads.In this study，the differences of alpha rhythm asymmetry between the dPD group and the ndPD group were compared and correlationship between the degree of alpha rhythm asymmetry and depression scale score were studied. Results：The prevalence of depression was 33.82% in 68 Parkinson′s disease patients in this study. The asymmetry of alpha rhythm（difference of alpha relative power） in the parietal and occipital lobe were statistical different between the dPD group and the ndPD group（parietal region：U=361.5，P=0.043；Occipital region U=329.5，P=0.015，respectively）; The differences between the relative power values of the left and right brain alpha rhythm in the parietal and occipital areas of Parkinson′s disease patients were both positively correlated with the depression score（ρ=0.307，P＜0.05；ρ=0.253，P＜0.05）. Conclusion：The asymmetries of α rhythms in bilateral parietal lobe and occipital lobe are useful for distinguishing Parkinson′s disease patients with or without depression and the degree of these asymmetries of α rhythms are obviously correlated with depression score，which indicated that the asymmetries of α rhythms in parietal and occipital regions could potentially be an electrophysiological marker of Parkinson′s disease patients with depression.

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备注/Memo

备注/Memo:

基金项目 天津市人民医院资助项目（2022YJ007）
作者简介 刘玲凤（1992-），女，医师，硕士在读，研究方向：神经电生理；通信作者：张美云，E-mail：zmy22202@aliyun.com。

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更新日期/Last Update: 1900-01-01