|本期目录/Table of Contents|

[1]张诗晗,张健.基于TCGA数据库分析HPRT1在口腔鳞状细胞癌中的表达及意义[J].天津医科大学学报,2022,28(02):129-134.
　ZHANG Shi-Han,ZHANG Jian.Expression and significance of HPRT1 in oral squamous cell carcinoma based on TCGA database[J].Journal of Tianjin Medical University,2022,28(02):129-134.
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基于TCGA数据库分析HPRT1在口腔鳞状细胞癌中的表达及意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
28卷
期数:
2022年02期
页码:
129-134
栏目:
生物信息学专题
出版日期:
2022-03-20

文章信息/Info

Title:
Expression and significance of HPRT1 in oral squamous cell carcinoma based on TCGA database
文章编号:
1006-8147(2022)02-0129-06
作者:
张诗晗; 张健
（天津医科大学口腔医院口腔颌面外科，天津300070）
Author(s):
ZHANG Shi-Han; ZHANG Jian
（Oral and Maxillofacial Surgery，Stomatological Hospital，Tianjin Medical University，Tianjin 300070，China）
关键词:
口腔鳞状细胞癌; HPRT1; 免疫浸润; 预后
Keywords:
oral squamous cell carcinoma; HPRT1; immune infiltration; prognosis
分类号:
R739.8
DOI:
-
文献标志码:
A
摘要:
目的：探讨次黄嘌呤磷酸核糖基转移酶1（HPRT1）在口腔鳞状细胞癌（OSCC）中的表达及功能。方法：下载TCGA数据库中的OSCC 转录样本（n=394），包括癌症组织（n = 362）及正常组织（n = 32），以及381例临床数据。分析HPRT1的表达与OSCC预后的关系。利用基因集富集分析探讨HPRT1在OSCC中可能的作用机制。探讨HPRT1与OSCC中免疫细胞的相关性。结果：HPRT1在OSCC组织中高表达（t =1.856，P<0.001），HPRT1高表达组的总生存率更差（P<0.05）。HPRT1与肿瘤分级、病理分期及T分期呈正相关。Cox回归分析结果提示HPRT1是OSCC预后的独立因素（P =0.002）。基因富集分析提示HPRT1可能与基础转录因子通路、细胞周期通路、DNA复制等通路（FDR<0.05，P< 0.05）以及氨酰-tRNA生物合成通路、碱基切除修复通路（P <0.05）有关。HPRT1高表达与调节性T细胞、休眠肥大细胞、中性粒细胞和嗜酸性粒细胞的含量具有相关性（均P< 0.05）。结论：HPRT1在OSCC组织中高表达并与OSCC的进展有关，可作为OSCC预后评估的潜在标记物。
Abstract:
Objective： To explore the expression and function of HPRT1 in oral squamous cell carcinoma （OSCC）. Methods:The OSCC transcription samples（n=394） in TCGA database were downloaded， including cancer tissues （n=362） and normal tissues （n=32），and 381 clinical data.The relationship between the expression of HPRT1 and the prognosis of OSCC was analyzed.The possible mechanism of HPRT1 in OSCC by GSEA was explored. The correlation between HPRT1 and immune cells in OSCC was explored. Results: HPRT1 was highly expressed in OSCC tissues （t=1.856，P< 0.001），the overall survival rate was worse in the HPRT1 high expression group （P<0.05）. HPRT1 was positively correlated with tumor grade， pathological stage and T stage. Cox regression analysis showed that HPRT1 was an independent factor in the prognosis of OSCC（P=0.002）. GSEA suggested that HPRT1 might be related to basal transcription factors pathway， cell cycle pathway，DNA replication pathway（FDR< 0.05，P< 0.05）， aminoacyl tRNA biosynthesis pathway and excision repair pathway （P< 0.05）. The high expression of HPRT1 was correlated with the contents of Tregs，mast cells resting， neutrophils and eosinophils（all P< 0.05）.Conclusion:HPRT1 is highly expressed in OSCC and is related to the progression of OSCC. It can be used as a potential marker for the prognosis of OSCC.

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相似文献/References:

[1]张 华,杨 蓉,叶贝贝,等.389例口腔鳞状细胞癌预后影响因素分析[J].天津医科大学学报,2018,24(04):315.
　ZHANG Hua,YANG Rong,YE Bei-bei,et al.Analysis of prognostic factors for 389 patients with oral squamous cell carcinoma[J].Journal of Tianjin Medical University,2018,24(02):315.

备注/Memo

备注/Memo:
作者简介 张诗晗（1996-），硕士在读，研究方向：骨组织缺损与修复；通信作者：张健，E-mail：zj301doctor@126.com。
更新日期/Last Update: 2022-03-20