[1] Cohen A T,Katholing A,Rietbrock S,et al. Epidemiology of first and recurrent venous thromboembolism in patients with active cancer: a population-based cohort study[J]. Thromb Haemost,2017,117(1):57
[2] Khorana A A,Francis C W,Culakova E,et al. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy[J]. Thromb Haemost,2007,5(3):632
[3] Prandoni P,Lensing A W,Piccioli A,et al. Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis[J]. Blood,2002,
100(10):3484
[4] Farge D,Frere C,Connors J M,et al. 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer[J]. Lancet Oncol,2019,20(10):e566
[5] Khorana A A,Carrier M,Garcia D A,et al. Guidance for the prevention and treatment of cancer-associated venous thromboembolism[J]. Thromb Thrombolysis,2016,41(1):81
[6] Ay C,Pabinger I,Cohen A T. Cancer-associated venous thromboembolism:burden,mechanisms,and management[J].Thromb Haemost,2017,117(2):219
[7] Rojas-Hernandez C M. The role of direct oral anticoagulants in cancer-related venous thromboembolism:a perspective beyond the guidelines[J]. Support Care Cancer,2018,26(3):711
[8] Mahé I,Elalamy I,Gerotziafas G T,et al. Treatment of cancer- associated thrombosis:beyond HOKUSAI[J].TH Open,2019,3(3):e348
[9] Raskob G E,van Es N,Verhamme P,et al. Edoxaban for the treatment of cancer-associated venous thromboembolism[J]. N Engl J Med,2018,378(7):615
[10] Young A M,Marshall A,Thirlwall J,et al. Comparison of an oral factor Xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism:results of a randomized trial (SELECT-D)[J]. Clin Oncol,2018,36(20):2017
[11] Agnelli G,Buller H R,Cohen A,et al. Oral apixaban for the treatment of acute venous Thromboembolism[J]. N Engl J Med,2013, 369(9):799
[12] Blom J W,Doggen C J,Osanto S,et al. Malignancies,prothrombotic mutations,and the risk of venous thrombosis[J]. JAMA,2005,
293(6):715
[13] Timp J F,Braekkan S K,Versteeg H H,et al. Epidemiology of cancer-associated venous thrombosis[J]. Blood,2013,122(10):1712
[14] Khorana A A,Kuderer N M,Culakova E,et al. Development and validation of a predictive model for chemotherapy-associated thrombosis[J]. Blood,2008,111(10):4902
[15] Chew H K,Wun T,Harvey D,et al. Incidence of venous thromboembolism and its effect on survival among patients with common cancers[J]. Arch Intern Med,2006,166(4):458
[16] Donnelan E,Kevane B,Bird B R,et al. Cancer and venous thromboembolic disease: from molecular mechanisms to clinical management[J]. Curr Oncol,2014,21(3):134
[17] Geddings J E,Mackman N. Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients[J]. Blood,2013,122(11):1873
[18] Tesselaar M E,Romijn F P,Linden I K,et al. Microparticle-associated tissue factor activity:a link between cancer and thrombosis[J]. Thromb Haemost,2007,5(3):520
[19] Menter D G,Tucker S C,Kopetz S,et al. Platelets and cancer: a casual or causal relationship:revisited[J]. Cancer Metastasis Rev,2014,33(1):231
[20] Wong P C,Jiang X. Apixaban,a direct factor Xa inhibitor,inhibits tissue-factor induced human platelet aggregation in vitro:comparison with direct inhibitors of factor Ⅶa,Ⅺa and thrombin[J]. Thromb Haemost,2010,104(2):302
[21] Byon W,Garonzik S,Boyd R A,et al. Apixaban:a clinical pharmacokinetic and pharmacodynamic review[J]. Clin Pharmacokinet,2019,58(10):1265
[22] Agnelli G,Buller H R,Cohen A,et al. Oral apixaban for the treatment of venous thromboembolism in cancer patients: results from the AMPLIFY trial[J]. Thromb Haemost,2015,13(12):2187
[23] McBaneli R,Loprinzi C L,Ashrani A,et al. Apixaban and dalteparin in active malignancy associated venous thromboembolism. The ADAM VTE Trial[J]. Thromb Haemost,2017,117(10):1952
[24] Agnelli G,Becattini C,Meyer G,et al. Apixaban for the treatment of venous thromboembolism associated with cancer[J]. N Engl J Med,2020,382(17):1599
[25] McBane R D,Loprinzi C L,AshraniA,et al. Extending venous thromboembolism secondary prevention with apixaban in cancer patients: the EVE trial[J]. Eur J Haematol,2020,104(2),88
[26] Stubblefield W B,Courtney D M,Self W H. Should cancer patients receive apixaban to prevent venous thromboembolism? An analysis of the AVERT trial[J]. Ann Emerg Med,2020,75(1):116
[27] Shaw J R,Kumar V,Mallick R,et al. Biomarker-enhanced VTE risk stratification in ambulatory patients with cancer[J]. Thromb Res,2020,
10(196),437
[28] Dawwas G K,Brown J,Dietrich E,et al. Effectiveness and safety of apixaban versus rivaroxaban for prevention of recurrent venous thromboembolism and adverse bleeding events in patients with venous thromboembolism: a retrospective population-based cohort analysis[J]. Lancet Haematol,2019,6(1):e20
[29] Li A,Kuderer N M,Garcia D A,et al. Direct oral anticoagulant for the prevention of thrombosis in ambulatory patients with cancer: asystematic review and meta-analysis[J]. J Thromb Haemost,2019,
17(12):2141