|本期目录/Table of Contents|

[1]高倩,姚晓雨 综述,隋磊 审校.微纳米分级形貌促进成骨细胞分化的分子机制研究进展[J].天津医科大学学报,2021,27(03):307-309,315.
点击复制

微纳米分级形貌促进成骨细胞分化的分子机制研究进展(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
27卷
期数:
2021年03期
页码:
307-309,315
栏目:
综述
出版日期:
2021-05-30

文章信息/Info

Title:
-
文章编号:
1006-8147(2021)03-0307-03
作者:
高倩; 姚晓雨 综述; 隋磊 审校
天津医科大学口腔医院口腔修复科，天津300070
Author(s):
-
关键词:
表面形貌; 微/纳米分级结构; 成骨; 成骨向分化
Keywords:
-
分类号:
R78
DOI:
-
文献标志码:
A
摘要:
种植材料表面形貌因素能够通过调控种植体周围细胞的成骨向分化，影响种植体周围的骨形成。目前研究表明，相较于单一的微米级或者纳米级形貌而言，微纳米分级形貌具有更强的促进细胞成骨向分化的能力，从而促进种植体周围的骨整合。微纳米分级形貌既能够通过调控诸多生物化学信号通路如Wnt/β-catenin、Hedgehog-Gli1、YAP/TAZ等，又能够影响表观遗传以及骨免疫微环境来促进种植体表面细胞成骨向分化。对微纳米分级形貌调控细胞成骨向分化的分子机制的研究，可以为功能活性种植体表面的设计与改良提供思路。
Abstract:
-

参考文献/References:

[1] Souza J M，Sordi M B，Kanazawa M，et al. Nano-scale modification of titanium implant surfaces to enhance osseointegration[J]. Acta Biomater，2019，94：112
[2] Chen L，Yong Y，Yang L J，et al. In vitro bioactivity and biocompatibility of Bio-Inspired Ti-6Al-4V alloy surfaces modified by combined laser micro/Nano structuring[J]. Molecules，2020，25（7）：1494
[3] Zhang J，Liu J，Wang C，et al. A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface[J]. Bioact Mater，2020， 5（1）：9
[4] Xu R G，Hu X C，Yu X L，et al. Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells[J]. Int J Nanomedicine，2018，13：5045
[5] Zhao X F，Xie L，Wang Z Y，et al. ZBP1（DAI/DLM-1）promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/beta-catenin signaling[J]. Bone Res，2020，8：12
[6] Wang W，Zhao L Z，Ma Q L，et al. The role of the Wnt/beta-catenin pathway in the effect of implant topography on MG63 differentiation[J]. Biomaterials，2012，33（32）：7993
[7] Boyan B D，Olivares-Navarrete R，Berge M B，et al. Role of wnt11 during osteogenic differentiation of human mesenchymalstem cells on microstructuredtitanium surfaces[J]. Sci Rep，2018，8（1）：8588
[8] Lopes H B，Souza A P，Freitas G P，et al. Effect of focal adhesion kinase inhibition on osteoblastic cells grown on Titanium with different topographies[J]. J Appl Oral Sci，2020，28：e20190156
[9] Liu Q，Wang W，Zhang L，et al.Involvement of N-cadherin/beta-catenin interaction in the micro/nanotopography induced indirect mechanotransduction[J]. Biomaterials，2014，35（24）：6206
[10] Yu Y L，Shen X K，Liu J J，et al. Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop[J]. Colloids Surf B Biointerfaces，2018，170：1
[11] Li G，Song Y，Shi M，et al. Mechanisms of Cdc42-mediated rat MSC differentiation on micro/nano-textured topography[J]. Acta Biomater，2017，49：235
[12] Yang J，Andre P，Ye L，et al. The Hedgehog signalling pathway in bone formation[J]. Int J Oral Sci，2015，7（2）：73
[13] Lin Y，Huang Y，He J，et al. Role of Hedgehog-Gli1 signaling in the enhanced proliferation and differentiation of MG63 cells enabled by hierarchical micro-/nanotextured topography[J]. Int J Nanomedicine， 2017，12：3267
[14] Ke G，Fu X C，Hui T，et al. TAZ promotes the proliferation and osteogenic differentiation of human periodontal ligament stem cells via the p-SMAD3[J]. J Cell Biochem，2020，121（2）：1101
[15] Pan H H，Xie Y T，Zhang Z Q，et al. YAP-mediated mechanotransduction regulates osteogenic and adipogenic differentiation of BMSCs on hierarchical structure[J]. Colloids Surf B Biointerfaces，2017， 152：344
[16] Hwang J H，Lee D H，Byun M R，et al. Nanotopological plate stimulates osteogenic differentiation through TAZ activation[J]. Sci Rep，2017，7（1）：3632
[17] Ohashi K，Fujiwara S，Mizuno K. Roles of the cytoskeleton，cell adhesion and rho signalling in mechanosensing and mechanotransduction[J]. J Biochem，2017，161（3）： 245
[18] Liu X，Hou W Q，He L，et al. AMOT130/YAP pathway in topography-induced BMSC osteoblasticdifferentiation[J]. Colloids Surf B Biointerfaces，2019，182：110332
[19] Wang W，Liu Q，Zhang Y M，et al. Involvement of ILK/ERK1/2 and ILK/p38 pathways in mediating the enhanced osteoblast differentiation by micro/nanotopography[J]. Acta Biomater，2014，10（8）：3705
[20] Nardone G，Oliver-De J L C，Vrbsky J，et al. YAP regulates cell mechanics by controlling focal adhesion assembly[J]. Nat Commun，2017，8：15321
[21] Liu Y，Zhang P，Zhang X，et al. Thenanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation[J]. Biomaterials，2015，39：193
[22] Zheng G Y，Guan B B，Hu P H，et al. Topographical cues of direct metal laser sintering titanium surfaces facilitate osteogenic differentiation of bone marrow mesenchymal stem cells through epigenetic regulation[J]. Cell Prolif，2018，51（4）：e12460
[23] 雒静. 微纳米形貌调控小鼠巨噬细胞M2极化促进种植体表面成骨分化的机制及应用研究[D]. 空军军医大学，2019
[24] Li R，Chen K L，Wang Y，et al. Establishment of a 3D printing system for bone tissue engineering scaffold fabrication and the evaluation of its controllability over macro and micro structure precision[J]. Beijing Da Xue Xue Bao，2019，51（1）：115
[25] Hasegawa M，Saruta J，Hirota M，et al. A newly created meso-，micro-，and Nano-Scale rough Titanium surface promotes Bone-Implant integration[J]. Int J Mol Sci，2020，21（3）：783

相似文献/References:

备注/Memo

备注/Memo:
基金项目 国家自然科学基金（81970958）；天津市研究生科研创新项目（2019YJSS170）
作者简介 高倩（1995-），女，硕士在读，研究方向：口腔材料；
通信作者：隋磊，E-mail：suilei@tmu.edu.cn。
更新日期/Last Update: 2021-05-30