|本期目录/Table of Contents|

[1]李文奎,苏悦,刘啸轩,等.缺血性脑卒中小鼠肾功能损害的相关研究[J].天津医科大学学报,2020,26(04):329-332,345.
　LI Wen-kui,SU Yue,LIU Xiao-xuan,et al.Correlative study on renal damage in mice with ischemic stroke[J].Journal of Tianjin Medical University,2020,26(04):329-332,345.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
26卷
期数:
2020年04期
页码:
329-332,345
栏目:
基础医学
出版日期:
2020-07-15

文章信息/Info

Title:
Correlative study on renal damage in mice with ischemic stroke
文章编号:
1006-8147(2020)04-0329-04
作者:
李文奎1; 苏悦1; 刘啸轩1; 乌日吉木斯1; 袁荃1; 阎涛1; 2
（1.天津医科大学总医院神经病学研究所，天津300052；2.天津医科大学总医院神经内科，天津300052）
Author(s):
LI Wen-kui1; SU Yue1; LIU Xiao-xuan1; WU Ri-jimusi1; YUAN Quan1; YAN Tao1; 2
（1. Tianjin Neurological Institute, General Hospital, Tianjin Medical University, Tianjin 300052, China; 2. Department of Neurology, General Hospital, Tianjin Medical University, Tianjin 300052, China）
关键词:
缺血性脑卒中; 急性肾功能损害; 肾组织病理损害
Keywords:
stroke; renal damage; renal pathological damage
分类号:
R743.3
DOI:
-
文献标志码:
A
摘要:
目的：研究小鼠缺血性脑卒中后的肾功能和肾组织改变，探讨缺血性脑卒中和肾功能损害的关系。方法：采用光化学法诱导局灶性大脑皮层缺血性脑卒中模型。在造模第3、28天，对小鼠进行血肌酐（PCr）、血尿素氮（BUN）检测以及肾脏病理评分（RPS）、肾小球基底膜厚度（TGBM）、肾组织纤维化程度（RFR）测评；在造模后第3、7、14、28天，检测尿白蛋白（UA）、尿β2-微球蛋白（β2-M）和尿肌酐（UCr）。结果：小鼠缺血性脑卒中后第3天，BUN、UA、尿β2-M、RPS、TGBM和RFR升高（t=6.885、2.638、3.804、2.181、4.262、7.366，均P<0.05）。缺血性脑卒中后第28天，RPS、RFR继续升高（t =2.791、6.187，均P<0.05）。结论：小鼠缺血性脑卒中可导致急性肾功能损害，同时可以导致急性和慢性肾脏病理损害。
Abstract:
Objective: To study the changes of renal function and renal tissue after ischemic stroke in mice, and to explore the relationship between ischemic stroke and renal dysfunction. Methods: A model of focal cerebral ischemic stroke was induced by photochemical method. On the 3rd and 28th day after modeling, plasma creatinine(PCr), blood urea nitrogen(BUN), renal pathology score(BPS), thickness of glomerular basement membrane(TGBM) and renal fibrosis rate(RFR) were detected in mice. On the 3rd, 7th, 14th, and 28th days after modeling, urine albumin(UA), urine β2-microglobulin(β2-M), and urine creatinine(UCr) were detected. Results: On the third day after ischemic stroke in mice, BUN, UA, urine β2-M, RPS, TGBM, and RFR were increased(t=6.885,2.638,3.804,2.181,4.262,7.366, all P<0.05).On the 28th day after ischemic stroke, RPS and RFR were continued to increase(t =2.791, 6.187, all P<0.05). Conclusion: Ischemic stroke in mice can cause acute renal damage, as well as acute and chronic renal pathological damage.

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备注/Memo

备注/Memo:
基金项目 天津市自然科学基金重点项目（17JCZDJC36100）
作者简介 李文奎（1992-），男，硕士在读，研究方向：神经病学；
通信作者：阎涛，E-mail：yantao78@hotmail.com。
更新日期/Last Update: 2020-07-15