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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

26卷

期数:

2020年03期

页码:

276-279

栏目:

技术与方法

出版日期:

2020-06-10

文章信息/Info

Title:

In vitro antibacterial activity study of tigecycline combined with 5 antibacterial agents against CRKP

文章编号:

1006-8147(2020)03-0276-04

作者:

郎磊¹;  李娜¹; 陈露¹; 芦晓庆¹; 朱立勤¹; 2; 张坚磊³

（1.天津医科大学一中心临床学院药剂科，天津 300192；2.天津市第一中心医院药剂科，天津 300192；3.天津市第一中心医院检验科，天津300192）

Author(s):

LANG Lei¹;  LI Na¹;  CHEN Lu¹;  LU Xiao-qing¹;  ZHU Li-qin¹; 2;  ZHANG Jian-lei³

（1.Department of Pharmacy, The First Central Clinical College，Tianjin Medical University, Tianjin 300192, China；2.Department of Pharmacy, Tianjin First Central Hospital, Tianjin 300192, China；3.Department of Clinical Laboratory, Tianjin First Central Hospital，Tianjin 300192, China）

关键词:

替加环素; 复方新诺明; 联合用药; 耐碳青霉烯肺炎克雷伯菌

Keywords:

tigecycline; co-trimoxazole; combination therapy; CRKP

分类号:

R978

DOI:

-

文献标志码:

A

摘要:

目的：评价替加环素分别联合磷霉素等多种抗菌药物对耐碳青霉烯的肺炎克雷伯菌(CRKP)的作用。方法：采用E-test法测定替加环素分别联用不同机制抗菌药物对临床分离的CRKP的最低抑菌浓度(MIC)，并计算部分抑菌浓度指数（FICI）。结果：替加环素和复方新诺明对CRKP显示是敏感，其余耐药。替加环素联合复方新诺明，在体外复方新诺明对替加环素的抗菌作用表现出局部协同作用，替加环素其他联合方案对CRKP显示无相关作用。结论：替加环素联合复方新诺明在体外对CRKP具有一定抗菌效应。

Abstract:

Objective: To evaluate the effects of tigecycline combined with fosfomycin and other antibacterial agents on carbapenem-resistant Klebsiella pneumoniae(CRKP). Methods: E-test was used to determine the minimum inhibitory concentration (MIC) of tigecycline combined with different mechanisms of antibacterial agents for clinically isolated CRKP, and the fractional inhibitory concentration index (FICI) was calculated. Results: Tigecycline and cotrimoxazole were sensitive to CRKP and the rest were resistant. The antibacterial effect of tigecycline combined with sulfamethoxazole showed local synergy in vitro, and other combinations of tigecycline showed no correlation with CRKP. Conclusion: Tigecycline combined with sulfamethoxazole has a certain antibacterial effect on CRKP in vitro.

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备注/Memo

备注/Memo:

基金项目 天津市临床重点学科建设资助项目（津卫科教〔2018〕268号）
作者简介 郎磊(1986-)，男，硕士在读，研究方向：药理学；通信作者：朱立勤，E-mail: zlq0713@aliyun.com；张坚磊，E-mail : 570184102@qq.com。

常用功能

更新日期/Last Update: 2020-06-13