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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

26卷

期数:

2020年03期

页码:

266-270

栏目:

技术与方法

出版日期:

2020-06-10

文章信息/Info

Title:

Inflammatory markers related to insulin resistance and impaired islet β-cell function in people with impaired fasting glucose: a correlation analysis

文章编号:

1006-8147(2020)03-0266-05

作者:

张晓莉¹; 2; 梁书卉²; Sam Wilfried Noel¹; 王阳¹; 孙续国¹; 郑芳¹

（1.天津医科大学医学检验学院，天津300203；2.天津市河西区康复医院检验科，天津300202）

Author(s):

ZHANG Xiao-li¹; 2; LIANG Shu-hui²; Sam Wilfried Noel¹; WANG Yang¹; SUN Xu-guo¹; ZHENG Fang¹

（1. School of Laboratory Medicine, Tianjin Medical University， Tianjin 300203, China； 2. Department of Clinical Laboratory, Hexi Rehabilitation Hospital, Tianjin 300202, China）

关键词:

空腹血糖受损; 炎症; 胰岛素抵抗; 胰岛β细胞

Keywords:

impaired fasting glucose; inflammation; insulin resistance; islet beta cell

分类号:

R446.1

DOI:

-

文献标志码:

A

摘要:

目的：探讨空腹血糖受损（IFG）人群的炎症标志物与胰岛素抵抗(IR)、胰岛β细胞功能的相关性。方法：以IFG组为研究对象，2型糖尿病组（T2DM）和健康正常组（HC）为对照，分析IFG人群炎症指标如超敏C反应蛋白（Hs-CRP）、血沉（ESR）、中性粒细胞/淋巴细胞比值（NLR）、单核细胞/淋巴细胞比值（MLR）和血小板/淋巴细胞比值（PLR）与糖代谢指标[空腹血糖（FPG）和糖化血红蛋白（HbA1c）]、胰岛素代谢指标[空腹胰岛素（FINS）、稳态模型评估胰岛素抵抗指数（HOMA-IR）和稳态模型评估胰岛β细胞功能指数（HOMA-β）]等的相关性。结果：3组炎症指标Hs-CRP、NLR和ESR之间有差异（均P＜0.05）；IFG组Hs-CRP与FPG、HbA1c、FINS、HOMA-IR均呈正相关（r分别为0.330、0.270、0.387、0.330，均P＜0.05），与HOMA-β呈负相关（r为-0.387，P＜0.05））；NLR与FPG、 HbA1c、 HOMA-IR均呈正相关（r分别为0.218、0.363、0.336，均P＜0.05），与HOMA-β呈负相关（r为-0.289，P＜0.05）。结论：IFG人群的炎症标志物Hs-CRP、NLR与胰岛素抵抗、胰岛β细胞功能受损具有相关性。

Abstract:

Objective: To investigate the relationship between inflammatory markers, insulin resistance (IR) and islet β-cell function in patients with impaired fasting glucose(IFG). Methods： The IFG group was used as the study group, type 2 diabetes group(T2DM) and healthy control(HC) were used as the control groups. The correlation between inflammatory markers [high-sensitivity C-reactive protein (Hs-CRP), erythrocyte sedimentation rate(ESR), neutrophil/lymphocyte ratio(NLR), monocyte/lymphocyte ratio(MLR) and platelet/ lymphocyte ratio(PLR)] and glucose metabolism indicators[fasting blood glucose(FPG), glycated hemoglobin(HbA1c)]and insulin metabolism indicators [fasting insulin(FINS),homeostatic model assessment of insulin resistance(HOMA-IR)，homeostasis modelassessment-β cell function ( HOMA-β) ] were analyzed. Results：There were significant difference in Hs-CRP, NLR and ESR between three groups(all P＜0.05). Hs-CRP was positively correlated with FPG, HbA1c, FINS and HOMA-IR in IFG group (r =0.330, 0.270, 0.387, 0.330, all P＜0.05, respectively)，while negatively correlated with HOMA-β(r =-0.387, P＜0.05). NLR was positively correlated with FPG, HbA1c and HOMA-IR (r =0.218, 0.363, 0.336, all P＜0.05), but negatively correlated with HOMA-β (r=-0.289, P＜0.05). Conclusion: The inflammatory markers Hs-CRP and NLR in people with IFG are associated with insulin resistance and impaired islet β cell function.

参考文献/References:

[1] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南（2013年版）[J].中国糖尿病杂志, 2014, 38(8):2
[2] Kim C H, Kim H K, Kim E H, et al. Longitudinal changes in insulin resistance, beta-cell function and glucose regulation status in prediabetes[J]. Am J Med Sci, 2018, 355(1):54
[3] Tabák A G, Herder C, Rathmann W, et al. Prediabetes: a high-risk state for diabetes development[J]. Lancet, 2012, 379(9833):2279
[4] 张黎明,高凌.炎症细胞因子在2型糖尿病发病机制中的研究进展[J]. 重庆医学, 2016, 45(8):1113
[5] Lou M, Luo P, Tang R, et al. Relationship between neutrophil- lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients[J]. BMC Endocr Disord, 2015,15:9
[6] 万方. 2型糖尿病患者C反应蛋白水平与胰岛素抵抗的相关性研究[J]. 中国当代医药, 2018, 25(34):105
[7] Amer D A. Standards of medical care in diabetes-2010[J]. Diabetes Care, 2010, 33(1):S11
[8] Matthews D R, Hosker J P, Rudenski A S, et al.Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia, 1985, 28(7):412
[9] Cai X, Xia L, Pan Y, et al. Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population[J]. Diabetol Metab Syndr, 2019, 11(1):24
[10] 刘芳芳,鲍雪,侍洪斌,等. 天津市体检人群糖尿病前期的流行病学调查[J]. 天津医科大学学报, 2016, 22(3):249
[11] 贺星星,马晓静,应令雯,等. 新诊断标准下糖尿病前期人群胰岛β细胞功能和胰岛素敏感性的特点分析[J]. 上海交通大学学报（医学版），2018, 38(8):941
[12] 王楠.糖尿病肾病患者发生肾病综合征的相关因素分析[D].重庆:重庆医科大学, 2018
[13] Freeman D J, Norrie J, Caslake M J, et al. C-reactive protein is an Independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study[J]. Diabetes, 2002, 51(5): 1596
[14] 陈袁,赵倩,康琪, 等. 脂蛋白(a), 超敏C反应蛋白表达水平与胰岛素抵抗的相关性研究[J]. 中国现代医学杂志, 2019, 29(6):39
[15] Imtiaz F, Shafique K, Mirza S S, et al. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population[J]. Int Arch Med, 2012, 5(1):2
[16] Yue S, Zhang J H, Wu J Y, et al. Use of the Monocyte-to-lymphocyte ratio to predict diabetic retinopathy[J]. Int J Environ Res Public Health, 2015, 12(8):10009
[17] 黄婉静,刘清杏,廖永康,等.中性粒细胞与淋巴细胞的比值在早期糖尿病肾病患者中的变化及意义[J].天津医药,2015,43(2):214
[18] Mertoglu C, Gunay M. Neutrophil-lymphocyte ratio and platelet- lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus[J]. Diabetes Metab Syndr, 2017, 11(Suppl 1):S127
[19] Fatih S. Reinvestigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus[J]. J Int Med Res, 2014, 42(2):581

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备注/Memo

备注/Memo:

作者简介 张晓莉（1986-），女，硕士在读，研究方向：免疫相关疾病；通信作者:郑芳,E-mail:zhengfang@tmu.edu.cn

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更新日期/Last Update: 2020-06-13